Proteintech

Caspase 1/p20/p10 Polyclonal Antibody

652 References

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Datasheet

Protocols

Questions & Answers

Caspase 1/p20/p10 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

Caspase 1/p20/p10 Antibody (22915-1-AP) in ICC/IF

Immunofluorescent analysis of C6 cells using 22915-1-AP (Caspase 1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Caspase 1/p20/p10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Caspase 1/p20/p10 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

22915-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 477 publications 477 publications

Immunohistochemistry (IHC)

View 88 publications 88 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

View 87 publications 87 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Caspase 1/p20/p10 Fusion Protein Ag11143 (1-311 aa encoded by BC062327)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

22915-1-AP can recognize all five isoforms of caspase 1. It also recognizes p45 procaspase and the mature fragments p10 and p20.

Immunogen sequence: MADKVLKEK RKLFIRSMGE APQAVQDNPA MPTSSGSEGN VKLCSLEEAQ RIWKQKSAEI YPIMDKSSRT RLALIICNEE FDSIPRRTGA EVDITGMTML LQNLGYSVDV KKNLTASDMT TELEAFAHRP EHKTSDSTFL VFMSHGIREG ICGKKHSEQV PDILQLNAIF NMLNTKNCPS LKDKPKVIII QACRGDSPGV VWFKDSVGVS GNLSLPTTEE FEDDAIKKAH IEKDFIAFCS STPDNVSWRH PTMGSVFIGR LIEHMQEYAC SCDVEEIFRK VRFSFEQPDG RAQMPTTERV TLTRCFYLFP GH (1-311 aa encoded by BC062327)

Target Information

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1-b and IL-18. Caspase-1 was initially identified as an IL-1-b-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.

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Wed Feb 08 00:00:00 EST 2023

Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.

Journal of agricultural and food chemistry

Liu D,Tian Q,Liu K,Ren F,Liu G,Zhou J,Yuan L,Fang Z,Zou B,Wang S

Wed Feb 08 00:00:00 EST 2023

Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache.

Frontiers in molecular neuroscience

Wang Y,Dong L,Zhang Y,Zhang Y,Qin G,Zhang D,Chen L,He W,Zhou J

Sat Jul 01 00:00:00 EDT 2023

TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.

Biology

Chen Y,Xiao L,Sun G,Li M,Yang H,Ming Z,Zhao K,Shang X,Zhang H,Liu C

Sun Jan 29 00:00:00 EST 2023

Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.

Planta medica

Zhang F,Ke C,Zhou Z,Xu K,Wang Y,Liu Y,Tu J

Sat Apr 01 00:00:00 EDT 2023

Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation.

Theranostics

You Z,Huang X,Xiang Y,Dai J,Xu L,Jiang J,Xu J

Wed Jan 04 00:00:00 EST 2023

Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.

The international journal of biochemistry & cell biology

Xu Z,Zhang G,Zhang X,Lei Y,Sun Y,He Y,Yang F,Nan W,Xing X,Li Y,Lin J

Sat Apr 01 00:00:00 EDT 2023

Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation.

iScience

Fang L,Ohashi K,Hayakawa S,Ogawa H,Otaka N,Kawanishi H,Takikawa T,Ozaki Y,Takahara K,Tatsumi M,Takefuji M,Shimizu Y,Bando YK,Fujishima Y,Maeda N,Shimomura I,Murohara T,Ouchi N

Fri May 19 00:00:00 EDT 2023

Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.

Pharmacological research

Zeng B,Chen Y,Chen H,Zhao Q,Sun Z,Liu D,Li X,Zhang Y,Wang J,Xing HR

Wed Feb 01 00:00:00 EST 2023

CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.

The Canadian journal of cardiology

Yao Y,Cao Y,Xu Y,Chen G,Liu Y,Jiang H,Fan R,Qin W,Wang X,Chai H,Chen X,Qiu Z,Chen W

Sun Oct 01 00:00:00 EDT 2023

CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.

The Canadian journal of cardiology

Yao Y,Cao Y,Xu Y,Chen G,Liu Y,Jiang H,Fan R,Qin W,Wang X,Chai H,Chen X,Qiu Z,Chen W

Sun Oct 01 00:00:00 EDT 2023

Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome.

Journal of ethnopharmacology

Zhang X,Wang Z,Li X,Chen J,Yu Z,Li X,Sun C,Hu L,Wu M,Liu L

Mon Jun 12 00:00:00 EDT 2023

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.

Mediators of inflammation

He YF,Hu XM,Khan MA,Yu BY,Sheng YC,Xiao XZ,Wan XX,Tan SP,Xiong K

Thu Feb 09 00:00:00 EST 2023

HBx-induced PLA₂R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway.

Renal failure

Feng M,Yu Y,Chen Y,Yang X,Li B,Jiang W

Fri Dec 01 00:00:00 EST 2023

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway.

International immunopharmacology

Jiang X,Li Y,Fu D,You T,Wu S,Xin J,Wen J,Huang Y,Hu C

Sun Jan 01 00:00:00 EST 2023

Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.

Redox biology

Zeng Z,You M,Fan C,Rong R,Li H,Xia X

Thu Jun 01 00:00:00 EDT 2023

Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.

Redox biology

Zeng Z,You M,Fan C,Rong R,Li H,Xia X

Thu Jun 01 00:00:00 EDT 2023

Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation.

Translational stroke research

Wang Z,Zhang S,Du J,Lachance BB,Chen S,Polster BM,Jia X

Sun Oct 01 00:00:00 EDT 2023

The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.

Orthopaedic surgery

Yao B,Cai Y,Wang W,Deng J,Zhao L,Han Z,Wan L

Wed Mar 01 00:00:00 EST 2023

MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.

International journal of biological macromolecules

Chen C,Wang Q,Li D,Qi Z,Chen Y,Wang S

Wed May 31 00:00:00 EDT 2023

Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.

Life sciences

Gao Z,Zhan H,Zong W,Sun M,Linghu L,Wang G,Meng F,Chen M

Tue Aug 15 00:00:00 EDT 2023

Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.

Vascular

Wang F,Fan X,Kong J,Wang C,Ma B,Sun W,Ye Z,Liu P,Wen J

Thu Jun 01 00:00:00 EDT 2023

Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism.

International journal of molecular sciences

Delcroix V,Mauduit O,Yang M,Srivastava A,Umazume T,de Paiva CS,Shestopalov VI,Dartt DA,Makarenkova HP

Tue Feb 21 00:00:00 EST 2023

HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARγ/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice.

Neuropharmacology

Li Y,Liu C,Wang G,Wang H,Liu X,Huang C,Chen Y,Fan L,Zhou L,Tong A

Sun Oct 01 00:00:00 EDT 2023

Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling.

Biomolecules & biomedicine

Yan J,Feng G,Yang Y,Ding D,Ma L,Zhao X,Chen X,Wang H,Chen Z,Jin Q

Wed Feb 01 00:00:00 EST 2023

Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.

Toxicology letters

Yang X,Dong S,Li C,Li M,Xing C,He J,Peng C,Shao H,Jia Q

Wed Mar 01 00:00:00 EST 2023

DBDPE upregulates NOD-like receptor signaling to induce NLRP3 inflammasome-mediated HAECs pyroptosis.

Environmental pollution (Barking, Essex : 1987)

Jing L,Zheng D,Sun X,Shi Z

Wed Feb 01 00:00:00 EST 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Thu Feb 23 00:00:00 EST 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Thu Feb 23 00:00:00 EST 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Thu Feb 23 00:00:00 EST 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Thu Feb 23 00:00:00 EST 2023

Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.

Toxins

Kang TH,Shin S,Park J,Lee BR,Lee SI

Wed Apr 19 00:00:00 EDT 2023

Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.

Toxins

Kang TH,Shin S,Park J,Lee BR,Lee SI

Wed Apr 19 00:00:00 EDT 2023

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.

Journal of agricultural and food chemistry

Tian Y,Feng X,Zhou Z,Qin S,Chen S,Zhao J,Hou J,Liu D

Wed Jan 25 00:00:00 EST 2023

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.

Journal of agricultural and food chemistry

Tian Y,Feng X,Zhou Z,Qin S,Chen S,Zhao J,Hou J,Liu D

Wed Jan 25 00:00:00 EST 2023

Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.

Nutrients

Lam HYP,Liang TR,Peng SY

Sat Apr 15 00:00:00 EDT 2023

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.

Acta biochimica et biophysica Sinica

Wu Y,Pi D,Zhou S,Yi Z,Dong Y,Wang W,Ye H,Chen Y,Zuo Q,Ouyang M

Wed Apr 19 00:00:00 EDT 2023

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.

Acta biochimica et biophysica Sinica

Wu Y,Pi D,Zhou S,Yi Z,Dong Y,Wang W,Ye H,Chen Y,Zuo Q,Ouyang M

Wed Apr 19 00:00:00 EDT 2023

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.

Acta biochimica et biophysica Sinica

Wu Y,Pi D,Zhou S,Yi Z,Dong Y,Wang W,Ye H,Chen Y,Zuo Q,Ouyang M

Wed Apr 19 00:00:00 EDT 2023

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.

Acta biochimica et biophysica Sinica

Wu Y,Pi D,Zhou S,Yi Z,Dong Y,Wang W,Ye H,Chen Y,Zuo Q,Ouyang M

Wed Apr 19 00:00:00 EDT 2023

Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.

Journal of ophthalmology

Xue L,Huang L,Tian Y,Cao X,Song Y

Sat Mar 11 00:00:00 EST 2023

Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice.

Frontiers in immunology

Cao Y,Shi M,Liu L,Zuo Y,Jia H,Min X,Liu X,Chen Z,Zhou Y,Li S,Yang G,Liu X,Deng Q,Chen F,Chen X,Zhang S,Zhang J

Mon May 08 00:00:00 EDT 2023

STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Liu H,Hu Y,Luo G,Yuan Z,Tu B,Ruan H,Li J,Fan C

Mon May 01 00:00:00 EDT 2023

Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.

Apoptosis : an international journal on programmed cell death

Ding L,Yin J,Xu X,Xie D,Xiang D,Tong P,Liu S,Yang X

Sat Apr 01 00:00:00 EDT 2023

Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.

Apoptosis : an international journal on programmed cell death

Ding L,Yin J,Xu X,Xie D,Xiang D,Tong P,Liu S,Yang X

Sat Apr 01 00:00:00 EDT 2023

Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.

Apoptosis : an international journal on programmed cell death

Ding L,Yin J,Xu X,Xie D,Xiang D,Tong P,Liu S,Yang X

Sat Apr 01 00:00:00 EDT 2023

SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy.

Biochemical pharmacology

Sun Z,Fang C,Xu S,Wang B,Li D,Liu X,Mi Y,Guo H,Jiang J

Sun Jan 01 00:00:00 EST 2023

SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy.

Biochemical pharmacology

Sun Z,Fang C,Xu S,Wang B,Li D,Liu X,Mi Y,Guo H,Jiang J

Sun Jan 01 00:00:00 EST 2023

SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy.

Biochemical pharmacology

Sun Z,Fang C,Xu S,Wang B,Li D,Liu X,Mi Y,Guo H,Jiang J

Sun Jan 01 00:00:00 EST 2023

Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis.

International immunopharmacology

Gu L,Lin J,Wang Q,Zhang L,Yin M,Lin H,Zheng H,Zhao G,Li C

Wed Feb 01 00:00:00 EST 2023

Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis.

International immunopharmacology

Gu L,Lin J,Wang Q,Zhang L,Yin M,Lin H,Zheng H,Zhao G,Li C

Wed Feb 01 00:00:00 EST 2023

Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wang X,Wu FP,Huang YR,Li HD,Cao XY,You Y,Meng ZF,Sun KY,Shen XY

Sun Jan 01 00:00:00 EST 2023

DDX3X Deficiency Attenuates Pyroptosis Induced by Oxygen-glucose Deprivation/Reoxygenation in N2a Cells.

Current neurovascular research

Liu Y,Gui Y,Tang H,Yu J,Yuan Z,Liu L,Ma X,Li C

Thu Aug 31 00:00:00 EDT 2023

Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.

Molecular neurobiology

Yan M,Jin H,Pan C,Han X

Wed Feb 01 00:00:00 EST 2023

Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.

Molecular neurobiology

Yan M,Jin H,Pan C,Han X

Wed Feb 01 00:00:00 EST 2023

Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.

International immunopharmacology

Zhou J,Yan S,Guo X,Gao Y,Chen S,Li X,Zhang Y,Wang Q,Zheng T,Chen L

Sun Jan 01 00:00:00 EST 2023

Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.

Brain research bulletin

Zhang JR,Yin SY,Shen ZQ,Li B,Zhang YQ,Yu J

Sat Apr 01 00:00:00 EDT 2023

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model.

Investigative ophthalmology & visual science

Yu Z,Yazdanpanah G,Alam J,de Paiva CS,Pflugfelder S

Mon Apr 03 00:00:00 EDT 2023

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.

Frontiers in cardiovascular medicine

Xu L,Zeng Z,Niu C,Liu D,Lin S,Liu X,Szabó G,Lu J,Zheng S,Zhou P

Tue Apr 04 00:00:00 EDT 2023

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.

Frontiers in cardiovascular medicine

Xu L,Zeng Z,Niu C,Liu D,Lin S,Liu X,Szabó G,Lu J,Zheng S,Zhou P

Tue Apr 04 00:00:00 EDT 2023

IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice.

Immunology

Yang D,Li Y,Liu T,Yang L,He L,Huang T,Zhang L,Luo J,Liu C

Wed Mar 29 00:00:00 EDT 2023

Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.

European journal of pharmacology

Zhou S,Li Y,Hong Y,Zhong Z,Zhao M

Sat Apr 15 00:00:00 EDT 2023

Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.

European journal of pharmacology

Zhou S,Li Y,Hong Y,Zhong Z,Zhao M

Sat Apr 15 00:00:00 EDT 2023

Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.

European journal of pharmacology

Zhou S,Li Y,Hong Y,Zhong Z,Zhao M

Sat Apr 15 00:00:00 EDT 2023

Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.

European journal of pharmacology

Zhou S,Li Y,Hong Y,Zhong Z,Zhao M

Sat Apr 15 00:00:00 EDT 2023

HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.

Vaccines

Chen N,Chen P,Zhou Y,Chen S,Gong S,Fu M,Geng L

Wed May 17 00:00:00 EDT 2023

Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.

Journal of orthopaedic translation

Chen Y,Liu Y,Jiang K,Wen Z,Cao X,Wu S

Wed Mar 01 00:00:00 EST 2023

Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.

Journal of orthopaedic translation

Chen Y,Liu Y,Jiang K,Wen Z,Cao X,Wu S

Wed Mar 01 00:00:00 EST 2023

CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.

Brain, behavior, and immunity

Li J,Wang H,Liu D,Li X,He L,Pan J,Shen Q,Peng Y

Mon May 01 00:00:00 EDT 2023

Brain, behavior, and immunity

Li J,Wang H,Liu D,Li X,He L,Pan J,Shen Q,Peng Y

Mon May 01 00:00:00 EDT 2023

Brain, behavior, and immunity

Li J,Wang H,Liu D,Li X,He L,Pan J,Shen Q,Peng Y

Mon May 01 00:00:00 EDT 2023

Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.

Journal of diabetes research

He J,Cui J,Shi Y,Wang T,Xin J,Li Y,Shan X,Zhu Z,Gao Y

Mon Jun 05 00:00:00 EDT 2023

Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.

Journal of diabetes research

He J,Cui J,Shi Y,Wang T,Xin J,Li Y,Shan X,Zhu Z,Gao Y

Mon Jun 05 00:00:00 EDT 2023

Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis.

The American journal of pathology

Wang B,Yang X,Zuo X,Zeng H,Wang X,Huang H,He D,Wang L,Ouyang H,Yuan J

Sat Jul 01 00:00:00 EDT 2023

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

Translational research : the journal of laboratory and clinical medicine

An X,Wu W,Yang L,Dong J,Liu B,Guo J,Chen J,Guo B,Cao W,Jiang Q

Fri Sep 01 00:00:00 EDT 2023

Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.

Ecotoxicology and environmental safety

Zhu X,Hao W,Liu Z,Song Y,Hao C,Wu S,Lu X,Yang J,Jin C

Sun Jan 01 00:00:00 EST 2023

Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.

Free radical biology & medicine

Sun MX,Qiao FX,Xu ZR,Liu YC,Xu CL,Wang HL,Qi ZQ,Liu Y

Tue Aug 01 00:00:00 EDT 2023

Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.

Neurochemical research

An D,Xu W,Ge Y,Ge Y,Zhang L,Zhu Y,Zhang Z,Fan J,Gao R,Jiang L,Huang P,Wang J,Chen X

Fri Sep 01 00:00:00 EDT 2023

NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.

International journal of biological sciences

Zhou H,Zhang Q,Huang W,Zhou S,Wang Y,Zeng X,Wang H,Xie W,Kong H

Tue Apr 18 00:00:00 EDT 2023

NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.

International journal of biological sciences

Zhou H,Zhang Q,Huang W,Zhou S,Wang Y,Zeng X,Wang H,Xie W,Kong H

Tue Apr 18 00:00:00 EDT 2023

Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liu M,Liu R,Yang M,Ba Y,Deng Q,Zhang Y,Han L,Gao L,Huang H

Sat Jul 01 00:00:00 EDT 2023

Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation.

Metabolic brain disease

Lai ZK,Yin YY,Yan JZ,Wei QQ,Wang B,Li YF,Zhang LM,Wang YL

Tue Aug 01 00:00:00 EDT 2023

Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome.

Frontiers in immunology

Zhang T,Tian J,Fan J,Liu X,Wang R

Mon Feb 27 00:00:00 EST 2023

Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway.

Oxidative medicine and cellular longevity

Yue T,Li X,Chen X,Zhu T,Li W,Wang B,Hang C

Mon Jan 30 00:00:00 EST 2023

Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Andrology

Chen Y,Wang L,Huang ZS,Feng JX,Li SX,Du ZJ,Zhang ZB,Liu J,Yang J,Hu ZM,Wang ZL,Chen J

Wed Mar 01 00:00:00 EST 2023

MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition.

Current medical science

Xiang DD,Liu JT,Zhong ZB,Xiong Y,Kong HY,Yu HJ,Peng T,Huang JQ

Thu Jun 01 00:00:00 EDT 2023

Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Xu L,Zhang F,Cheng G,Yuan X,Wu Y,Wu H,Wang Q,Chen J,Kuai J,Chang Y,Wei W,Yan S

Sun Jan 01 00:00:00 EST 2023

Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Xu L,Zhang F,Cheng G,Yuan X,Wu Y,Wu H,Wang Q,Chen J,Kuai J,Chang Y,Wei W,Yan S

Sun Jan 01 00:00:00 EST 2023

Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Xu L,Zhang F,Cheng G,Yuan X,Wu Y,Wu H,Wang Q,Chen J,Kuai J,Chang Y,Wei W,Yan S

Sun Jan 01 00:00:00 EST 2023

A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.

bioRxiv : the preprint server for biology

Hom LM,Sun S,Campbell J,Liu P,Culbert S,Murphy IM,Schafer ZT

Wed Feb 22 00:00:00 EST 2023

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors.

Bone & joint research

Bai Z,Shou Z,Hu K,Yu J,Meng H,Chen C

Tue Mar 07 00:00:00 EST 2023

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors.

Bone & joint research

Bai Z,Shou Z,Hu K,Yu J,Meng H,Chen C

Tue Mar 07 00:00:00 EST 2023

ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.

Acta biomaterialia

Muhammad W,Zhu J,Zhai Z,Xie J,Zhou J,Feng X,Feng B,Pan Q,Li S,Venkatesan R,Li P,Cao H,Gao C

Mon Aug 01 00:00:00 EDT 2022

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.

Frontiers in endocrinology

Luo C,Peng Y,Zhou X,Fan J,Chen W,Zhang H,Wei A

Tue Aug 09 00:00:00 EDT 2022

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.

Frontiers in endocrinology

Luo C,Peng Y,Zhou X,Fan J,Chen W,Zhang H,Wei A

Tue Aug 09 00:00:00 EDT 2022

Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.

Inflammation

Zhu M,Wang Y,Zhu L,Du S,Wang Z,Zhang Y,Guo Y,Tu Y,Song E

Tue Feb 01 00:00:00 EST 2022

Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.

International journal of molecular sciences

Yang G,Wang J,Wang S,Zhu Y

Sat Aug 20 00:00:00 EDT 2022

Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Zhang K,Chai B,Ji H,Chen L,Ma Y,Zhu L,Xu J,Wu Y,Lan Y,Li H,Feng Z,Xiao J,Zhang H,Xu K

Sat Jan 01 00:00:00 EST 2022

Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Zhang K,Chai B,Ji H,Chen L,Ma Y,Zhu L,Xu J,Wu Y,Lan Y,Li H,Feng Z,Xiao J,Zhang H,Xu K

Sat Jan 01 00:00:00 EST 2022

LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.

Molecular medicine (Cambridge, Mass.)

Wang X,Li Q,He S,Bai J,Ma C,Zhang L,Guan X,Yuan H,Li Y,Zhu X,Mei J,Gao F,Zhu D

Tue Oct 25 00:00:00 EDT 2022

LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.

Molecular medicine (Cambridge, Mass.)

Wang X,Li Q,He S,Bai J,Ma C,Zhang L,Guan X,Yuan H,Li Y,Zhu X,Mei J,Gao F,Zhu D

Tue Oct 25 00:00:00 EDT 2022

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.

International journal for parasitology

Lam HYP,Cheng PC,Peng SY

Fri Apr 01 00:00:00 EDT 2022

Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.

Frontiers in immunology

Deng H,Zhu S,Zhu L,Sun J,Ding Y,Li F,Jian Z,Zhao J,Deng L,Deng J,Deng Y,Guo H,Sun X,Lai SY,Tang H,Cui H,Ge LP,Xu Z

Mon Aug 15 00:00:00 EDT 2022

ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.

Cell death discovery

Li L,Cui YJ,Liu Y,Li HX,Su YD,Li SN,Wang LL,Zhao YW,Wang SX,Yan F,Dong B

Mon Apr 04 00:00:00 EDT 2022

ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.

Cell death discovery

Li L,Cui YJ,Liu Y,Li HX,Su YD,Li SN,Wang LL,Zhao YW,Wang SX,Yan F,Dong B

Mon Apr 04 00:00:00 EDT 2022

ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.

Cell death discovery

Li L,Cui YJ,Liu Y,Li HX,Su YD,Li SN,Wang LL,Zhao YW,Wang SX,Yan F,Dong B

Mon Apr 04 00:00:00 EDT 2022

ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.

Cell death discovery

Li L,Cui YJ,Liu Y,Li HX,Su YD,Li SN,Wang LL,Zhao YW,Wang SX,Yan F,Dong B

Mon Apr 04 00:00:00 EDT 2022

MCC950 attenuates inflammation-mediated damage in canines with Staphylococcus pseudintermedius keratitis by inhibiting the NLRP3 inflammasome.

International immunopharmacology

Guo L,Wang Z,Li J,Cui L,Dong J,Meng X,Zhu G,Li J,Wang H

Fri Jul 01 00:00:00 EDT 2022

Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.

Free radical biology & medicine

Wang F,Liang Q,Ma Y,Sun M,Li T,Lin L,Sun Z,Duan J

Tue Mar 01 00:00:00 EST 2022

Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.

Frontiers in bioscience (Landmark edition)

Xiao Q,Kang Z,Liu C,Tang B

Thu Nov 03 00:00:00 EDT 2022

RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery.

Journal of controlled release : official journal of the Controlled Release Society

Ding Y,Lv B,Zheng J,Lu C,Liu J,Lei Y,Yang M,Wang Y,Li Z,Yang Y,Gong W,Han J,Gao C

Sat Jan 01 00:00:00 EST 2022

Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Guo Y,Yang JH,He Y,Zhou HF,Wang Y,Ding ZS,Jin B,Wan HT

Sat Jan 01 00:00:00 EST 2022

Adipose stem cells preincubated with theanine exert liver regeneration through increase of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage induced by N-nitrosodiethylamine.

Life sciences

Chen TS,Lai YA,Lai YJ,Chien CT

Tue Nov 01 00:00:00 EDT 2022

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation.

Acta cirurgica brasileira

Li D,Yang Z,Gao S,Zhang H,Fan G

Mon Nov 07 00:00:00 EST 2022

Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.

Food & function

Wang Z,Li C,He X,Xu K,Xue Z,Wang T,Xu Z,Liu X

Mon Apr 04 00:00:00 EDT 2022

LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sun Y,Teng Y,Wang L,Zhang Z,Chen C,Wang Y,Zhang X,Xiang P,Song X,Lu J,Li N,Gao L,Liang X,Xia Y,Wu Z,Ma C

Sun May 01 00:00:00 EDT 2022

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Zhang X,Li C,Chen D,He X,Zhao Y,Bao L,Wang Q,Zhou J,Xie Y

Sat Jan 01 00:00:00 EST 2022

Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.

Frontiers in physiology

Wang X,Long H,Chen M,Zhou Z,Wu Q,Xu S,Li G,Lu Z

Tue Jan 03 00:00:00 EST 2023

Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.

Frontiers in physiology

Chen R,Chen T,Zhou Z,Song Z,Feng W,Yang X,Wang X,Li B,Ding X,Zhang H,Wang Y

Fri Sep 30 00:00:00 EDT 2022

Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.

Frontiers in physiology

Chen R,Chen T,Zhou Z,Song Z,Feng W,Yang X,Wang X,Li B,Ding X,Zhang H,Wang Y

Fri Sep 30 00:00:00 EDT 2022

Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway.

Epilepsy & behavior : E&B

Xiang T,Luo X,Ye L,Huang H,Wu Y

Tue Mar 01 00:00:00 EST 2022

Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Oxidative medicine and cellular longevity

Bai L,Dai J,Xia Y,He K,Xue H,Guo Q,Tian D,Xiao L,Zhang X,Teng X,Wu Y,Jin S

Tue Aug 02 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.

Frontiers in pharmacology

Liao C,Wang D,Qin S,Zhang Y,Chen J,Xu R,Xu F,Zhang P

Sat Jul 16 00:00:00 EDT 2022

Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.

Virulence

Fan W,Wang Y,Jiang S,Li Y,Yao X,Wang M,Zhao J,Sun X,Jiang X,Zhong L,Han Y,Song H,Xu Y

Thu Dec 01 00:00:00 EST 2022

Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor.

Cell death discovery

Tang H,Li J,Zhou Q,Li S,Xie C,Niu L,Ma J,Li C

Tue Feb 08 00:00:00 EST 2022

Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome.

Disease markers

Xu L,Liu X,Zhang Y,Jia T,Li L,Du Y,Chen W,Zhang S

Fri Dec 30 00:00:00 EST 2022

PM_2.5 induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis.

Immunobiology

Ren F,Xu J,Zhang J,Xu X,Huang L,Sun W,Li R,Li F

Sun May 01 00:00:00 EDT 2022

Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.

European journal of pharmacology

He G,Chen K,Wang H,Li X,Li W,Liu L,Chen J,Yang D,Hu J,Xu D,Wen F,Wang T

Tue Jul 05 00:00:00 EDT 2022

Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.

BMC anesthesiology

Zheng X,Gong T,Tang C,Zhong Y,Shi L,Fang X,Chen D,Zhu Z

Thu Dec 01 00:00:00 EST 2022

α₁ -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.

Experimental physiology

Chen L,Wang W,Peng X,Liu L,Zhang A,Li X,Ma K,Wang L

Wed Jun 01 00:00:00 EDT 2022

α₁ -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.

Experimental physiology

Chen L,Wang W,Peng X,Liu L,Zhang A,Li X,Ma K,Wang L

Wed Jun 01 00:00:00 EDT 2022

α₁ -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.

Experimental physiology

Chen L,Wang W,Peng X,Liu L,Zhang A,Li X,Ma K,Wang L

Wed Jun 01 00:00:00 EDT 2022

Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.

Biochemical and biophysical research communications

Han N,Wang Z,Luo H,Chi Y,Zhang T,Wang B,Li Y

Sat Jun 25 00:00:00 EDT 2022

Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.

Frontiers in pharmacology

Hou Q,Kan S,Wang Z,Shi J,Zeng C,Yang D,Jiang S,Liu Z

Tue Aug 02 00:00:00 EDT 2022

Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.

Free radical biology & medicine

Zou R,Nie C,Pan S,Wang B,Hong X,Xi S,Bai J,Yu M,Liu J,Yang W

Fri Apr 01 00:00:00 EDT 2022

Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.

Free radical biology & medicine

Zou R,Nie C,Pan S,Wang B,Hong X,Xi S,Bai J,Yu M,Liu J,Yang W

Fri Apr 01 00:00:00 EDT 2022

Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.

Nutrients

Yu J,Liu T,Gao Z,Liu R,Wang Z,Chen Y,Cao J,Dong Y

Sat Jul 30 00:00:00 EDT 2022

Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.

EBioMedicine

Luo Y,Zhang Y,Han X,Yuan Y,Zhou Y,Gao Y,Yu H,Zhang J,Shi Y,Duan Y,Zhao X,Yan S,Hao H,Dai C,Zhao S,Shi J,Li W,Zhang S,Xu W,Fang N,Gong Y,Li Y

Mon Aug 01 00:00:00 EDT 2022

Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.

Frontiers in pharmacology

Li DD,Fan HX,Yang R,Li YY,Zhang F,Shi JS

Sat Jul 16 00:00:00 EDT 2022

ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.

DNA and cell biology

Tang Q,Liu W,Yang X,Tian Y,Chen J,Hu Y,Fu N

Thu Dec 01 00:00:00 EST 2022

ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.

DNA and cell biology

Tang Q,Liu W,Yang X,Tian Y,Chen J,Hu Y,Fu N

Thu Dec 01 00:00:00 EST 2022

Staphylococcal Enterotoxin A Induces Intestinal Barrier Dysfunction and Activates NLRP3 Inflammasome via NF-κB/MAPK Signaling Pathways in Mice.

Toxins

Liu C,Chi K,Yang M,Guo N

Sat Jan 01 00:00:00 EST 2022

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.

Frontiers in nutrition

Liu Y,Wei Y,Wu L,Lin X,Sun R,Chen H,Shen S,Deng G

Tue May 03 00:00:00 EDT 2022

Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.

Chemico-biological interactions

Dong PF,Li ZF,Lian CY,Wang ZY,Wang L

Thu Dec 01 00:00:00 EST 2022

Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.

Chemico-biological interactions

Dong PF,Li ZF,Lian CY,Wang ZY,Wang L

Thu Dec 01 00:00:00 EST 2022

Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells.

BioMed research international

Cui C,Wang X,Zhang S,Wu H,Li M,Dong L,Yan C,Li D

Tue Aug 23 00:00:00 EDT 2022

Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner.

The Journal of toxicological sciences

Xing H,Liu Q,Hou Y,Tian Z,Liu J

Fri Jun 03 00:00:00 EDT 2022

Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu Y,Sun R,Lin X,Wu L,Chen H,Shen S,Li Y,Wei Y,Deng G

Fri Jul 01 00:00:00 EDT 2022

Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI.

Cell death discovery

Li T,Sun H,Li Y,Su L,Jiang J,Liu Y,Jiang N,Huang R,Zhang J,Peng Z

Mon Feb 14 00:00:00 EST 2022

Carbenoxolone Ameliorates Allergic Airway Inflammation through NF-κB/NLRP3 Pathway in Mice.

Biological & pharmaceutical bulletin

He F,Cheng Q,Li N,Shang Y

Wed Jun 01 00:00:00 EDT 2022

Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.

Frontiers in nutrition

Chen Z,Tang Z,Kong J,Chen L,Liu J,Li Y,Huang W,Li W,Wu J,Zhao W,Meng X,Fan H

Tue Jul 19 00:00:00 EDT 2022

IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.

Annals of the New York Academy of Sciences

Luo P,Zhao T,He H

Tue Feb 01 00:00:00 EST 2022

IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.

Annals of the New York Academy of Sciences

Luo P,Zhao T,He H

Tue Feb 01 00:00:00 EST 2022

Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.

Evidence-based complementary and alternative medicine : eCAM

Zhu Q,Meng P,Han Y,Yang H,Yang Q,Liu Z,Wang Y,Long M

Sat Jul 16 00:00:00 EDT 2022

Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1^G93A ALS mouse model.

BMC neuroscience

Zhang H,Li H,Huang B,Wang S,Gao Y,Meng F,Chen Y,Zhou F,Guan Y,Wang X

Tue Aug 09 00:00:00 EDT 2022

Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1^G93A ALS mouse model.

BMC neuroscience

Zhang H,Li H,Huang B,Wang S,Gao Y,Meng F,Chen Y,Zhou F,Guan Y,Wang X

Tue Aug 09 00:00:00 EDT 2022

Cynarin suppresses gouty arthritis induced by monosodium urate crystals.

Bioengineered

Wu C,Chen S,Liu Y,Kong B,Yan W,Jiang T,Tian H,Liu Z,Shi Q,Wang Y,Liang Q,Xi X,Xu H

Sun May 01 00:00:00 EDT 2022

Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.

Frontiers in pharmacology

Biao Y,Chen J,Liu C,Wang R,Han X,Li L,Zhang Y

Sat Jul 16 00:00:00 EDT 2022

Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.

Biochemical and biophysical research communications

Sun Y,Cong T,Li L,Li J,Wu H,Chen X,Zhou Y,Xiao Z

Sat Apr 30 00:00:00 EDT 2022

Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.

Biochemical and biophysical research communications

Sun Y,Cong T,Li L,Li J,Wu H,Chen X,Zhou Y,Xiao Z

Sat Apr 30 00:00:00 EDT 2022

CysLT₂R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.

Brain sciences

Zhou L,Zhang J,Han X,Fang J,Zhou S,Lu L,Shi Q,Ying H

Sun Jul 24 00:00:00 EDT 2022

CysLT₂R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.

Brain sciences

Zhou L,Zhang J,Han X,Fang J,Zhou S,Lu L,Shi Q,Ying H

Sun Jul 24 00:00:00 EDT 2022

Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis.

Frontiers in immunology

Chen P,Zhou YK,Han CS,Chen LJ,Wang YM,Zhuang ZM,Lin S,Zhou YH,Jiang JH,Yang RL

Thu Jun 02 00:00:00 EDT 2022

Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis.

Frontiers in immunology

Chen P,Zhou YK,Han CS,Chen LJ,Wang YM,Zhuang ZM,Lin S,Zhou YH,Jiang JH,Yang RL

Thu Jun 02 00:00:00 EDT 2022

Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner.

Experimental neurology

Xia P,Marjan M,Liu Z,Zhou W,Zhang Q,Cheng C,Zhao M,Tao Y,Wang Z,Ye Z

Tue Nov 01 00:00:00 EDT 2022

Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.

Apoptosis : an international journal on programmed cell death

Xin X,Yang K,Liu H,Li Y

Fri Apr 01 00:00:00 EDT 2022

Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.

Apoptosis : an international journal on programmed cell death

Xin X,Yang K,Liu H,Li Y

Fri Apr 01 00:00:00 EDT 2022

Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells.

Molecular medicine reports

Mo R,Zhang J,Chen Y,Ding Y

Tue Mar 01 00:00:00 EST 2022

Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.

Cells

Li Q,Hong Y,Chen J,Zhou X,Tian X,Yu Y,Shen L,Long C,Cai M,Wu S,Wei G

Tue Nov 29 00:00:00 EST 2022

Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.

Cells

Li Q,Hong Y,Chen J,Zhou X,Tian X,Yu Y,Shen L,Long C,Cai M,Wu S,Wei G

Tue Nov 29 00:00:00 EST 2022

Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.

Cells

Li Q,Hong Y,Chen J,Zhou X,Tian X,Yu Y,Shen L,Long C,Cai M,Wu S,Wei G

Tue Nov 29 00:00:00 EST 2022

Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.

Cells

Li Q,Hong Y,Chen J,Zhou X,Tian X,Yu Y,Shen L,Long C,Cai M,Wu S,Wei G

Tue Nov 29 00:00:00 EST 2022

Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.

Cutaneous and ocular toxicology

Xiao K,Shang J,Liu Y,Chen Z,Wang L,Long Q

Wed Jun 01 00:00:00 EDT 2022

Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.

Pharmaceutical biology

Hao YY,Cui WW,Gao HL,Wang MY,Liu Y,Li CR,Hou YL,Jia ZH

Thu Dec 01 00:00:00 EST 2022

Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells.

Free radical biology & medicine

Zhao W,Deng Z,Barkema HW,Xu M,Gao J,Liu G,Lin Y,Kastelic JP,Han B

Sun May 01 00:00:00 EDT 2022

A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization.

Experimental cell research

Hou L,Ye Y,Gou H,Tang H,Zhou Y,Xu X,Xu Y

Thu Sep 01 00:00:00 EDT 2022

MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway.

Life sciences

Wang F,Gu L,Wang Y,Sun D,Zhao Y,Meng Q,Yin L,Xu L,Lu X,Peng J,Lin Y,Sun P

Sat Oct 15 00:00:00 EDT 2022

Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.

Ecotoxicology and environmental safety

Jiang J,Ding S,Zhang G,Dong Y

Wed Jun 15 00:00:00 EDT 2022

The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage.

Annals of the New York Academy of Sciences

Rong R,Yang R,Li H,You M,Liang Z,Zeng Z,Zhou R,Xia X,Ji D

Tue Feb 01 00:00:00 EST 2022

Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome.

Journal of bioscience and bioengineering

Pei Y,Cheng F,Li W,Yu Q,Ma C,Zou Y,Xu T,Liu S,Zhang S,Wang Q

Tue Feb 01 00:00:00 EST 2022

Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome.

Veterinary research

Wang X,Liu M,Geng N,Du Y,Li Z,Gao X,Han B,Liu J,Liu Y

Sat Feb 05 00:00:00 EST 2022

NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits.

Journal of neuroinflammation

Li Z,Vidjro OE,Guo G,Du Y,Zhou Y,Xie Q,Li J,Gao K,Zhou L,Ma T

Tue Dec 20 00:00:00 EST 2022

Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.

European journal of pharmacology

Zhang L,Zhu XZ,Badamjav R,Zhang JZ,Kou JP,Yu BY,Li F

Tue Feb 15 00:00:00 EST 2022

Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.

Journal of inflammation research

Zhong Y,Cai X,Ding L,Liao J,Liu X,Huang Y,Chen X,Long L

Sun May 01 00:00:00 EDT 2022

MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.

Molecular immunology

Wu G,Zhang D,Yang L,Wu Q,Yuan L

Wed Jun 01 00:00:00 EDT 2022

Neuropeptide Y and receptors are associated with the pyroptosis of nucleus pulposus in aging and degenerative intervertebral discs of rats.

Neuropeptides

Li F,Xie W,Chen Z,Zhou Z,Wang Z,Xiao J,Li Z

Thu Dec 01 00:00:00 EST 2022

Neuropeptide Y and receptors are associated with the pyroptosis of nucleus pulposus in aging and degenerative intervertebral discs of rats.

Neuropeptides

Li F,Xie W,Chen Z,Zhou Z,Wang Z,Xiao J,Li Z

Thu Dec 01 00:00:00 EST 2022

Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways.

Neurochemical research

Yang L,Cheng J,Shi G,Zhang C,Du Y,Chen L,Qiao H,Chen R,Zhang X

Fri Jul 01 00:00:00 EDT 2022

Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways.

Neurochemical research

Yang L,Cheng J,Shi G,Zhang C,Du Y,Chen L,Qiao H,Chen R,Zhang X

Fri Jul 01 00:00:00 EDT 2022

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis.

Frontiers in immunology

Xu J,Zheng Y,Zhao Y,Zhang Y,Li H,Zhang A,Wang X,Wang W,Hou Y,Wang J

Mon May 02 00:00:00 EDT 2022

Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.

Frontiers in microbiology

Huo XY,Lei LR,Guo WX,Hu YJ,Kuang QX,Liu MD,Peng W,Dai YF,Wang D,Gu YC,Guo DL,Deng Y

Mon Sep 12 00:00:00 EDT 2022

The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Zhao W,He C,Jiang J,Zhao Z,Yuan H,Wang F,Shen B

Tue Nov 01 00:00:00 EDT 2022

Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes.

Frontiers in aging neuroscience

Ji X,Tian L,Niu S,Yao S,Qu C

Sat Sep 10 00:00:00 EDT 2022

β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows.

Frontiers in veterinary science

Dong Z,Sun X,Tang Y,Luo S,Jia H,Xu Q,Jiang Q,Loor JJ,Xu W,Xu C

Sat Sep 17 00:00:00 EDT 2022

GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma.

Journal of neuroinflammation

Liu M,Li H,Yang R,Ji D,Xia X

Wed Oct 26 00:00:00 EDT 2022

Paeoniflorin alleviates inflammatory response in IBS-D mouse model via downregulation of the NLRP3 inflammasome pathway with involvement of miR-29a.

Heliyon

Ke W,Wang Y,Huang S,Liu S,Zhu H,Xie X,Yang H,Lu Q,Gan J,He G,Che F,Wan X,Tang H

Thu Dec 01 00:00:00 EST 2022

EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.

Annals of translational medicine

Lu D,Yu M,Chen L,Ye J,Huang L,Zhu G,Lan B

Fri Apr 01 00:00:00 EDT 2022

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.

Cancers

Zhang Y,Xu T,Tian H,Wu J,Yu X,Zeng L,Liu F,Liu Q,Huang X

Thu Dec 15 00:00:00 EST 2022

Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.

Journal of ethnopharmacology

Zhou GQ,Chen G,Yang J,Qin WY,Ping J

Sun Jan 30 00:00:00 EST 2022

Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.

Antioxidants (Basel, Switzerland)

Sun H,Sun Z,Xu X,Lv Z,Li J,Wu R,Fei Y,Tan G,Liu Z,Liu Y,Shi D

Wed Nov 23 00:00:00 EST 2022

Human iPSC colon organoid function is improved by exposure to fecal fermentates.

FASEB bioAdvances

Pearce SC,Weber GJ,Doherty LA,Soares JW

Fri Jul 01 00:00:00 EDT 2022

Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice.

Aging cell

Hu C,Zhang X,Hu M,Teng T,Yuan YP,Song P,Kong CY,Xu SC,Ma ZG,Tang QZ

Tue Mar 01 00:00:00 EST 2022

Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.

International urology and nephrology

Song L,Yao S,Zheng D,Xuan Y,Li W

Wed Jun 01 00:00:00 EDT 2022

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Journal of neuroinflammation

Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T

Mon Jun 06 00:00:00 EDT 2022

MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.

BMC pulmonary medicine

Zhou P,Song NC,Zheng ZK,Li YQ,Li JS

Wed Jun 15 00:00:00 EDT 2022

Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.

Behavioural brain research

Wei Y,Hu Y,Qi K,Li Y,Chen J,Wang R

Sat Apr 09 00:00:00 EDT 2022

Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.

Frontiers in microbiology

Zhang KK,Chen LJ,Li JH,Liu JL,Wang LB,Xu LL,Yang JZ,Li XW,Xie XL,Wang Q

Sat May 07 00:00:00 EDT 2022

Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.

Neuroscience letters

Chen Y,Hao C,Chen W,Cheng W,Li P,Shen J,Tong T,Yan S,Huang S,He T,Huang Z,Meng X

Wed Aug 10 00:00:00 EDT 2022

Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats.

Experimental and therapeutic medicine

Yu S,Chen X,Li X,Yan J,Jiang Y

Fri Jul 01 00:00:00 EDT 2022

GABA regulates IL-1β production in macrophages.

Cell reports

Fu J,Han Z,Wu Z,Xia Y,Yang G,Yin Y,Ren W

Tue Dec 06 00:00:00 EST 2022

GABA regulates IL-1β production in macrophages.

Cell reports

Fu J,Han Z,Wu Z,Xia Y,Yang G,Yin Y,Ren W

Tue Dec 06 00:00:00 EST 2022

Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.

International journal of biological sciences

Qin X,Zhou Y,Jia C,Chao Z,Qin H,Liang J,Liu X,Liu Z,Sun T,Yuan Y,Zhang H

Fri Apr 15 00:00:00 EDT 2022

Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yan S,Lu W,Zhou J,Guo X,Li J,Cheng H,Zhu X,Zhao Y,Duan M,Yang H,Zhang Y,Wang Q,Chen L,Zheng T

Thu Sep 01 00:00:00 EDT 2022

Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.

Experimental gerontology

Zhou Z,Ying C,Zhou X,Shi Y,Xu J,Zhu Y,Wang M,Li Y,Li X,Xiang J

Sat Oct 15 00:00:00 EDT 2022

Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.

Experimental gerontology

Zhou Z,Ying C,Zhou X,Shi Y,Xu J,Zhu Y,Wang M,Li Y,Li X,Xiang J

Sat Oct 15 00:00:00 EDT 2022

Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.

International immunopharmacology

Song Z,Wang L,Cao Y,Liu Z,Zhang M,Zhang Z,Jiang S,Fan R,Hao T,Yang R,Wang B,Guan Z,Zhu L,Liu Z,Zhang S,Zhao L,Xu Z,Xu H,Dai G

Fri Apr 01 00:00:00 EDT 2022

Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.

International immunopharmacology

Song Z,Wang L,Cao Y,Liu Z,Zhang M,Zhang Z,Jiang S,Fan R,Hao T,Yang R,Wang B,Guan Z,Zhu L,Liu Z,Zhang S,Zhao L,Xu Z,Xu H,Dai G

Fri Apr 01 00:00:00 EDT 2022

N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.

Acta biochimica et biophysica Sinica

Huang L,Gong L,Huo X,Lei L,Zhang Q,Hu Y,Kuang Q,Gui Y,Dai Y,Gu Y,Deng Y,Wang D,Guo D

Thu Aug 25 00:00:00 EDT 2022

Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.

Frontiers in immunology

Wang Y,Liu F,Chen L,Fang C,Li S,Yuan S,Qian X,Yin Y,Yu B,Fu B,Zhang X,Li Y

Fri Jun 17 00:00:00 EDT 2022

Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.

Frontiers in immunology

Wang Y,Liu F,Chen L,Fang C,Li S,Yuan S,Qian X,Yin Y,Yu B,Fu B,Zhang X,Li Y

Fri Jun 17 00:00:00 EDT 2022

Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.

Molecular medicine (Cambridge, Mass.)

Zhou J,Lu Y,Jia Y,Lu J,Jiang Z,Chen K

Mon Jan 03 00:00:00 EST 2022

miR-513c-5p Suppression Aggravates Pyroptosis of Endothelial Cell in Deep Venous Thrombosis by Promoting Caspase-1.

Frontiers in cell and developmental biology

Chu C,Wang B,Zhang Z,Liu W,Sun S,Liang G,Zhang X,An H,Wei R,Zhu X,Guo Q,Zhao L,Fu X,Xu K,Li X

Sat Jul 16 00:00:00 EDT 2022

Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results.

Journal of inflammation research

Ding Z,Zhong Z,Wang J,Zhang R,Shao J,Li Y,Wu G,Tu H,Yuan W,Sun H,Wang Q

Tue Nov 01 00:00:00 EDT 2022

Mechanism of nonylphenol induced gastric inflammation through NF-κB/NLRP3 signaling pathway.

Toxicology

Xu J,Li S,Yang X,Wang H,Ma L,Shen Y,Yu J

Thu Sep 01 00:00:00 EDT 2022

IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.

Biochemical and biophysical research communications

Chen G,Xu Y,Fan R,Liu Y,Yao Y,Jiang H,Wu Q,Li L,Chen W,Chen X

Sat Jan 22 00:00:00 EST 2022

Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhao AN,Yang Z,Wang DD,Shi B,Zhang H,Bai Y,Yan BW,Zhang Y,Wen JK,Wang XL,Qu CB

Tue Nov 01 00:00:00 EDT 2022

Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhao AN,Yang Z,Wang DD,Shi B,Zhang H,Bai Y,Yan BW,Zhang Y,Wen JK,Wang XL,Qu CB

Tue Nov 01 00:00:00 EDT 2022

Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice.

International immunopharmacology

Meng LC,Zheng JY,Qiu YH,Zheng L,Zheng JY,Liu YQ,Miao XL,Lu XY

Sat Oct 01 00:00:00 EDT 2022

An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.

International journal of molecular sciences

Yang J,Li J,Guo H,Zhang Y,Guo Z,Liu Y,Huo T

Thu May 19 00:00:00 EDT 2022

Comprehensive Analysis of Prognostic Value and Immune Infiltration of NLRC4 and CASP1 in Colorectal Cancer.

International journal of general medicine

Peng L,Zhu N,Wang D,Zhou Y,Liu Y

Sat Jul 16 00:00:00 EDT 2022

Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement.

Pharmacological research

Han W,Cui C,Zhang H,Guo Y,Xie D,Zhang W,Wang C,Yang M,Jiang P

Sun May 01 00:00:00 EDT 2022

Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis.

International immunopharmacology

Zhou H,Zhang W,Qin D,Liu P,Fan W,Lv H,Tan L,Gao Z,Xu Y

Thu Sep 01 00:00:00 EDT 2022

Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.

Anais da Academia Brasileira de Ciencias

Huang J,Chen C,Xie J,Zhai K,Wei S,Cheng X,Zhang R

Thu Dec 15 00:00:00 EST 2022

Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.

Phytotherapy research : PTR

Yan K,Hu J,Hou T,Ci X,Peng L

Sun May 01 00:00:00 EDT 2022

Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes.

The Journal of investigative dermatology

Li W,Wang T,Huang WB,Li FG,Quan JH,Shi G,Zouboulis CC,Fan YM

Fri Jul 01 00:00:00 EDT 2022

Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes.

The Journal of investigative dermatology

Li W,Wang T,Huang WB,Li FG,Quan JH,Shi G,Zouboulis CC,Fan YM

Fri Jul 01 00:00:00 EDT 2022

Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes.

The Journal of investigative dermatology

Li W,Wang T,Huang WB,Li FG,Quan JH,Shi G,Zouboulis CC,Fan YM

Fri Jul 01 00:00:00 EDT 2022

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ying C,Zhou Z,Dai J,Wang M,Xiang J,Sun D,Zhou X

Tue Feb 01 00:00:00 EST 2022

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ying C,Zhou Z,Dai J,Wang M,Xiang J,Sun D,Zhou X

Tue Feb 01 00:00:00 EST 2022

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ying C,Zhou Z,Dai J,Wang M,Xiang J,Sun D,Zhou X

Tue Feb 01 00:00:00 EST 2022

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ying C,Zhou Z,Dai J,Wang M,Xiang J,Sun D,Zhou X

Tue Feb 01 00:00:00 EST 2022

Schisandra chinensis (Turcz.) Baill. Protects against DSS-induced colitis in mice: Involvement of TLR4/NF-κB/NLRP3 inflammasome pathway and gut microbiota.

Journal of ethnopharmacology

Bian Z,Qin Y,Li L,Su L,Fei C,Li Y,Hu M,Chen X,Zhang W,Mao C,Yuan X,Lu T,Ji D

Tue Nov 15 00:00:00 EST 2022

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice.

Nutrients

Yang F,Wang X,Qi J,Zhang K,Jiang Y,Feng B,Lv T,Yang L,Yang Q,Zhao M,Liu S,Ma X

Wed Dec 21 00:00:00 EST 2022

Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.

Clinical and experimental pharmacology & physiology

Zheng J,Liao Y,Xu Y,Mo Z

Fri Jul 01 00:00:00 EDT 2022

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Cancer cell international

Li W,Huang BS,Xiong YY,Yang LJ,Wu LX

Tue Jan 18 00:00:00 EST 2022

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Cancer cell international

Li W,Huang BS,Xiong YY,Yang LJ,Wu LX

Tue Jan 18 00:00:00 EST 2022

Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.

Frontiers in pharmacology

Cheng X,Huang T,Wang C,Hao S,Shu L,Wang S,Cheng G,Zhang Q,Huang J,Chen C

Sat Jul 16 00:00:00 EDT 2022

Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice.

Cell calcium

Yang S,Zhao Z,Zhao N,Liao J,Lu Y,Zhang S,Lu K,Wu Y,Wu Q,Dong Q,Chen L,Du Y

Wed Jun 01 00:00:00 EDT 2022

NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis.

Acta cirurgica brasileira

Shen Y,Yang H,Wu D,Yang H,Hong D

Fri Sep 29 00:00:00 EDT 2023

Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.

Oxidative medicine and cellular longevity

Shen F,Xie P,Li C,Bian Z,Wang X,Peng D,Zhu G

Tue Dec 13 00:00:00 EST 2022

Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway.

Journal of biochemical and molecular toxicology

Di M,Zhang Q,Wang J,Xiao X,Huang J,Ma Y,Yang H,Li M

Thu Dec 01 00:00:00 EST 2022

Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation.

Experimental and therapeutic medicine

Yan J,Ding D,Feng G,Yang Y,Zhou Y,Ma L,Guo H,Lu Z,Jin Q

Tue Mar 01 00:00:00 EST 2022

Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism.

Oxidative medicine and cellular longevity

Wang X,Huo R,Liang Z,Xu C,Chen T,Lin J,Li L,Lin W,Pan B,Fu X,Chen S

Fri May 06 00:00:00 EDT 2022

Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy.

Scientific reports

Li Y,Yu W,Xiong H,Yuan F

Thu Jul 14 00:00:00 EDT 2022

¿yclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.

Bulletin of experimental biology and medicine

Li X,Zhou JX,Qu YD,Kuang X

Thu Dec 01 00:00:00 EST 2022

Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.

Frontiers in pharmacology

Li W,Yang K,Li B,Wang Y,Liu J,Chen D,Diao Y

Wed Dec 21 00:00:00 EST 2022

Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.

Cardiovascular toxicology

Li Q,Zuo Z,Pan Y,Zhang Q,Xu L,Jiang B

Thu Sep 01 00:00:00 EDT 2022

Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.

Experimental eye research

Tan Y,Zhang M,Pan Y,Feng H,Xie L

Sat Jan 01 00:00:00 EST 2022

Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.

Experimental eye research

Tan Y,Zhang M,Pan Y,Feng H,Xie L

Sat Jan 01 00:00:00 EST 2022

Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway.

Particle and fibre toxicology

Chen YY,Lee YH,Wang BJ,Chen RJ,Wang YJ

Wed Jan 05 00:00:00 EST 2022

Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.

Cell cycle (Georgetown, Tex.)

Li M,Zhong X,Xu WT

Sat Oct 01 00:00:00 EDT 2022

HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.

Oxidative medicine and cellular longevity

Chang Y,Wu Y,Jiang X,Zhu J,Wang C,Ma R,Li G

Mon Aug 15 00:00:00 EDT 2022

Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.

Biochemical and biophysical research communications

Fan R,Jiang H,Hu Y,Xu Y,Zhou Y,Chen G,Liu Y,Yao Y,Qin W,Chen W,Huang F,Chen X

Sun Dec 25 00:00:00 EST 2022

Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).

Toxicology research

Li S,Zheng M,Yang X,Zhang J,Xu J,Yu J

Tue Feb 01 00:00:00 EST 2022

Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.

Frontiers in nutrition

Miao B,Zheng J,Zheng G,Tian X,Zhang W,Yuan F,Yang Z

Mon May 02 00:00:00 EDT 2022

Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.

International journal of molecular sciences

Shen W,Ma X,Shao D,Wu X,Wang S,Zheng J,Lv Y,Ding X,Ma B,Yan Z

Sun Nov 13 00:00:00 EST 2022

Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.

International journal of molecular sciences

Shen W,Ma X,Shao D,Wu X,Wang S,Zheng J,Lv Y,Ding X,Ma B,Yan Z

Sun Nov 13 00:00:00 EST 2022

Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.

International journal of molecular sciences

Shen W,Ma X,Shao D,Wu X,Wang S,Zheng J,Lv Y,Ding X,Ma B,Yan Z

Sun Nov 13 00:00:00 EST 2022

Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.

Frontiers in pharmacology

Gao T,Xu J,Xiao Y,Li J,Hu W,Su X,Shen X,Yu W,Chen Z,Huang B,Li H,Wang X

Tue Sep 20 00:00:00 EDT 2022

Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.

Journal of immunology research

Hong Q,Zhang Y,Lin W,Wang W,Yuan Y,Lin J,Xie Z,Li X,Meng Y

Tue Aug 30 00:00:00 EDT 2022

The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.

Neurochemical research

Wang YH,Gao X,Tang YR,Yu Y,Sun MJ,Chen FQ,Li Y

Tue Feb 01 00:00:00 EST 2022

Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome.

Journal of nanobiotechnology

Qian Z,Wang Q,Qiu Z,Li D,Zhang C,Xiong X,Zheng Z,Ruan Q,Guo Y,Guo J

Wed Jul 06 00:00:00 EDT 2022

Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-β in Spontaneously Hypertensive Rats.

Disease markers

Ge C,Zhao Y,Liang Y,He Y

Fri Jul 22 00:00:00 EDT 2022

LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.

Journal of cellular and molecular medicine

Gu J,Shi JZ,Wang YX,Liu L,Wang SB,Sun JT,Shan TK,Wang H,Wang QM,Wang LS

Sun May 01 00:00:00 EDT 2022

ROCK2 knockdown alleviates LPS-induced inflammatory injury and apoptosis of renal tubular epithelial cells via the NF-κB/NLRP3 signaling pathway.

Experimental and therapeutic medicine

Qian X,Yang L

Thu Sep 01 00:00:00 EDT 2022

Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.

The American journal of Chinese medicine

Huang ZW,Tan P,Yi XK,Chen H,Sun B,Shi H,Mou ZQ,Cheng YL,Li TX,Li Q,Fu WG

Fri Nov 25 00:00:00 EST 2022

Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.

Inflammation

Liu Y,Shang L,Zhou J,Pan G,Zhou F,Yang S

Fri Apr 01 00:00:00 EDT 2022

M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway.

European journal of pharmacology

Xu J,Lv Q,Pan S,Qiu H,Liao Y,Zhou M,Li W,Li C,Zhang P,Li Y,Xu G,Yu Q

Sat Oct 15 00:00:00 EDT 2022

M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway.

European journal of pharmacology

Xu J,Lv Q,Pan S,Qiu H,Liao Y,Zhou M,Li W,Li C,Zhang P,Li Y,Xu G,Yu Q

Sat Oct 15 00:00:00 EDT 2022

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.

Frontiers in cell and developmental biology

Jia S,Yang Y,Bai Y,Wei Y,Zhang H,Tian Y,Liu J,Bai L

Fri Apr 01 00:00:00 EDT 2022

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.

Frontiers in cell and developmental biology

Jia S,Yang Y,Bai Y,Wei Y,Zhang H,Tian Y,Liu J,Bai L

Fri Apr 01 00:00:00 EDT 2022

The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.

Journal of ethnopharmacology

Xu LT,Wang T,Fang KL,Zhao Y,Wang XN,Ren DM,Shen T

Sun Jan 30 00:00:00 EST 2022

Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zheng CM,Lu KC,Chen YJ,Li CY,Lee YH,Chiu HW

Sat Oct 01 00:00:00 EDT 2022

Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.

Antioxidants (Basel, Switzerland)

Liu G,Tao J,Lu J,Jia G,Zhao H,Chen X,Tian G,Cai J,Zhang R,Wang J

Thu Apr 28 00:00:00 EDT 2022

Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis.

Iranian journal of basic medical sciences

Yu Y,Dong H,Sun J,Li B,Chen Y,Feng M,Yang X,Jiang W

Sat Jan 01 00:00:00 EST 2022

USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.

Journal of musculoskeletal & neuronal interactions

Sun D,Peng Y,Ge S,Fu Q

Thu Dec 01 00:00:00 EST 2022

Mechanism of miR-126 in hypoxia-reoxygenation-induced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome.

Immunopharmacology and immunotoxicology

Fei L,Zhang N,Zhang J

Mon Aug 01 00:00:00 EDT 2022

Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Zhang Z,Hu Y,Liu W,Zhang X,Wang R,Li H,Sun D,Fang J

Fri Aug 05 00:00:00 EDT 2022

Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease.

Cell death & disease

Pang Q,Wang P,Pan Y,Dong X,Zhou T,Song X,Zhang A

Wed Mar 30 00:00:00 EDT 2022

Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.

Aging and disease

Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ

Tue Jun 01 00:00:00 EDT 2021

Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.

Oxidative medicine and cellular longevity

Ma W,Wang Z,Zhao Y,Wang Q,Zhang Y,Lei P,Lu W,Yan S,Zhou J,Li X,Yu W,Zhong Y,Chen L,Zheng T

Mon Sep 13 00:00:00 EDT 2021

GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.

Oxidative medicine and cellular longevity

Xu Y,Hu X,Li F,Zhang H,Lou J,Wang X,Wang H,Yin L,Ni W,Kong J,Wang X,Li Y,Zhou K,Xu H

Mon Feb 07 00:00:00 EST 2022

GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.

Oxidative medicine and cellular longevity

Xu Y,Hu X,Li F,Zhang H,Lou J,Wang X,Wang H,Yin L,Ni W,Kong J,Wang X,Li Y,Zhou K,Xu H

Mon Feb 07 00:00:00 EST 2022

Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.

Annals of translational medicine

Liu J,He J,Huang Y,Ge L,Xiao H,Zeng L,Jiang Z,Lu M,Hu Z

Wed Sep 01 00:00:00 EDT 2021

Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.

Evidence-based complementary and alternative medicine : eCAM

Zhang H,Zhao J,Lu Q,Sun B,Liu X,Yang C,Li S,Li L,Yi S,Yang Z,Xu J

Tue Nov 23 00:00:00 EST 2021

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Molecular medicine reports

Zhang X,Nie Q,Zhang Z,Zhao J,Zhang F,Wang C,Wang X,Song G

Sun Aug 01 00:00:00 EDT 2021

SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages.

International journal of biological sciences

Li S,Han S,Jin K,Yu T,Chen H,Zhou X,Tan Z,Zhang G

Mon Dec 20 00:00:00 EST 2021

Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.

International immunopharmacology

Ruan Y,Ling J,Ye F,Cheng N,Wu F,Tang Z,Cheng X,Liu H

Wed Dec 01 00:00:00 EST 2021

Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.

Cell death discovery

Feng YH,Li LF,Zhang Q,Zhang JH,Huang Y,Lv YL,Jia JZ,Zhang D,Hu JY,Huang YS

Thu Aug 12 00:00:00 EDT 2021

Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.

Cell death discovery

Feng YH,Li LF,Zhang Q,Zhang JH,Huang Y,Lv YL,Jia JZ,Zhang D,Hu JY,Huang YS

Thu Aug 12 00:00:00 EDT 2021

Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.

International immunopharmacology

Huang X,Shen H,Liu Y,Qiu S,Guo Y

Tue Jun 01 00:00:00 EDT 2021

CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.

Frontiers in pharmacology

Jiang X,Gu Y,Huang Y,Zhou Y,Pang N,Luo J,Tang Z,Zhang Z,Yang L

Tue Oct 12 00:00:00 EDT 2021

Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.

Life sciences

Zhang H,Luan S,Xiao X,Lin L,Zhao X,Liu X

Mon Feb 01 00:00:00 EST 2021

Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.

Laboratory investigation; a journal of technical methods and pathology

Liu Y,Li YP,Xiao LM,Chen LK,Zheng SY,Zeng EM,Xu CH

Thu Jul 01 00:00:00 EDT 2021

Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.

Journal of neuroinflammation

Cao LL,Guan PP,Zhang SQ,Yang Y,Huang XS,Wang P

Fri Dec 03 00:00:00 EST 2021

Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.

International journal of immunopathology and pharmacology

Yu Y,Chen D,Zhao Y,Zhu J,Dong X

Tue Feb 01 00:00:00 EST 2022

Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.

International journal of immunopathology and pharmacology

Yu Y,Chen D,Zhao Y,Zhu J,Dong X

Tue Feb 01 00:00:00 EST 2022

A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.

eLife

Li J,Qin X,Shi J,Wang X,Li T,Xu M,Chen X,Zhao Y,Han J,Piao Y,Zhang W,Qu P,Wang L,Xiang R,Shi Y

Fri Jun 11 00:00:00 EDT 2021

Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.

Frontiers in immunology

Zheng Z,Wang T,Chen J,Qiu H,Zhang C,Liu W,Qin S,Tian J,Guo J

Wed Oct 27 00:00:00 EDT 2021

The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.

Frontiers in cell and developmental biology

Meihe L,Shan G,Minchao K,Xiaoling W,Peng A,Xili W,Jin Z,Huimin D

Wed Sep 08 00:00:00 EDT 2021

The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.

Frontiers in cell and developmental biology

Meihe L,Shan G,Minchao K,Xiaoling W,Peng A,Xili W,Jin Z,Huimin D

Wed Sep 08 00:00:00 EDT 2021

MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy.

Brain research

Du Y,Lu Z,Yang D,Wang D,Jiang L,Shen Y,Du Q,Yu W

Wed Sep 01 00:00:00 EDT 2021

Wogonin Alleviates Cisplatin-induced Cardiotoxicity in Mice Via Inhibiting Gasdermin D-mediated Pyroptosis.

Journal of cardiovascular pharmacology

Xu J,Zhang B,Chu Z,Jiang F,Han J

Wed Jun 16 00:00:00 EDT 2021

An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism.

Frontiers in pharmacology

Gao Y,Shi W,Yao H,Ai Y,Li R,Wang Z,Liu T,Dai W,Xiao X,Zhao J,Niu M,Bai Z

Tue Oct 12 00:00:00 EDT 2021

Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.

Cardiovascular drugs and therapy

Jiang W,Geng H,Lv X,Ma J,Liu F,Lin P,Yan C

Wed Dec 01 00:00:00 EST 2021

MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.

Brain research bulletin

Wu X,Zhang Y,Zhang Y,Xia L,Yang Y,Wang P,Xu Y,Ren Z,Liu H

Wed Dec 01 00:00:00 EST 2021

Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.

Journal of bioenergetics and biomembranes

Liu X,Leng Y,Lv X,Lv J,Zhang M,Shi Y

Wed Dec 01 00:00:00 EST 2021

Cordyceps acid alleviates lung cancer in nude mice.

Journal of biochemical and molecular toxicology

Wang J,Chen H,Li W,Shan L

Mon Mar 01 00:00:00 EST 2021

NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.

Chemosphere

Zheng D,Shi Z,Yang M,Liang B,Zhou X,Jing L,Sun Z

Mon Mar 01 00:00:00 EST 2021

NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.

Chemosphere

Zheng D,Shi Z,Yang M,Liang B,Zhou X,Jing L,Sun Z

Mon Mar 01 00:00:00 EST 2021

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.

ImmunoHorizons

Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD

Wed Jul 21 00:00:00 EDT 2021

Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.

Archives of oral biology

Zeng X,Luo X,Mao X,Wen D,Zhang H,Wang J

Mon Nov 01 00:00:00 EDT 2021

Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.

Archives of oral biology

Zeng X,Luo X,Mao X,Wen D,Zhang H,Wang J

Mon Nov 01 00:00:00 EDT 2021

Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation.

Clinical science (London, England : 1979)

Ge C,Cheng Y,Fan Y,He Y

Fri Jun 11 00:00:00 EDT 2021

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.

Oxidative medicine and cellular longevity

Li Z,Huang Z,Zhang H,Lu J,Tian Y,Wei Y,Yang Y,Bai L

Thu Sep 02 00:00:00 EDT 2021

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.

Oxidative medicine and cellular longevity

Li Z,Huang Z,Zhang H,Lu J,Tian Y,Wei Y,Yang Y,Bai L

Thu Sep 02 00:00:00 EDT 2021

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.

Oxidative medicine and cellular longevity

Li Z,Huang Z,Zhang H,Lu J,Tian Y,Wei Y,Yang Y,Bai L

Thu Sep 02 00:00:00 EDT 2021

LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.

Ecotoxicology and environmental safety

Zhang Y,Guo S,Wang S,Li X,Hou D,Li H,Wang L,Xu Y,Ma B,Wang H,Jiang X

Wed Sep 01 00:00:00 EDT 2021

Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zeng J,Tao J,Xia L,Zeng Z,Chen J,Wang Z,Meng J,Liu L

Tue Jun 01 00:00:00 EDT 2021

Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.

International journal of molecular medicine

Feng H,Zhu X,Tang Y,Fu S,Kong B,Liu X

Sun Aug 01 00:00:00 EDT 2021

Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.

International journal of molecular medicine

Feng H,Zhu X,Tang Y,Fu S,Kong B,Liu X

Sun Aug 01 00:00:00 EDT 2021

Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

The Journal of clinical investigation

Jauhari A,Baranov SV,Suofu Y,Kim J,Singh T,Yablonska S,Li F,Wang X,Oberly P,Minnigh MB,Poloyac SM,Carlisle DL,Friedlander RM

Mon May 03 00:00:00 EDT 2021

Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.

Experimental eye research

Yu X,Ma X,Lin W,Xu Q,Zhou H,Kuang H

Fri Jan 01 00:00:00 EST 2021

Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.

Clinical rheumatology

Hou CC,Ma HF,Ye JF,Luo D,Bao HF,Guan JL

Fri Oct 01 00:00:00 EDT 2021

Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.

Clinical rheumatology

Hou CC,Ma HF,Ye JF,Luo D,Bao HF,Guan JL

Fri Oct 01 00:00:00 EDT 2021

Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.

Annals of neurology

Xu C,Zhang S,Gong Y,Nao J,Shen Y,Tan B,Xu S,Cui S,Ruan Y,Wang S,Wang Y,Chen Z

Wed Sep 01 00:00:00 EDT 2021

Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.

Frontiers in pharmacology

Liu X,Xu Y,Cheng S,Zhou X,Zhou F,He P,Hu F,Zhang L,Chen Y,Jia Y

Tue Jul 27 00:00:00 EDT 2021

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Scientific reports

Zhao Y,Liu X,Zheng Y,Liu W,Ding C

Mon Oct 18 00:00:00 EDT 2021

Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.

Journal of ethnopharmacology

Li A,Wu X,Yang J,Li J,Guo H,Zhang Y,Jiang H,Huo T

Sun Dec 05 00:00:00 EST 2021

Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.

Oxidative medicine and cellular longevity

Li DF,Chang X,Zhao JL,Chen XM,Xu ZL,Zhang DG,Wu BH,Wang LS,Bai Y,Yao J

Wed Jan 05 00:00:00 EST 2022

Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.

Veterinary research

Zhao W,He F,Barkema HW,Xu S,Gao J,Liu G,Deng Z,Shahid M,Shi Y,Kastelic JP,Han B

Sat Dec 11 00:00:00 EST 2021

Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.

Neural plasticity

Lyu Z,Chan Y,Li Q,Zhang Q,Liu K,Xiang J,Li X,Cai D,Li Y,Wang B,Yu Z

Thu Jan 20 00:00:00 EST 2022

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.

Oxidative medicine and cellular longevity

Zhang Y,Liu W,Zhong Y,Li Q,Wu M,Yang L,Liu X,Zou L

Tue Feb 08 00:00:00 EST 2022

Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.

Evidence-based complementary and alternative medicine : eCAM

Wang B,Lyu Z,Chan Y,Li Q,Zhang L,Liu K,Li Y,Yu Z

Wed Sep 29 00:00:00 EDT 2021

Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.

Microorganisms

Chen S,Li Y,Chu B,Yuan L,Liu N,Zhu Y,Wang J

Fri Sep 17 00:00:00 EDT 2021

Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.

International journal of molecular medicine

Qin ZY,Gu X,Chen YL,Liu JB,Hou CX,Lin SY,Hao NN,Liang Y,Chen W,Meng HY

Fri Jan 01 00:00:00 EST 2021

Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.

International journal of molecular medicine

Qin ZY,Gu X,Chen YL,Liu JB,Hou CX,Lin SY,Hao NN,Liang Y,Chen W,Meng HY

Fri Jan 01 00:00:00 EST 2021

Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.

Experimental and therapeutic medicine

Xiang N,Yin T,Chen T

Fri Oct 01 00:00:00 EDT 2021

Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.

Journal of cellular physiology

Li J,Chen H,Lou J,Bao G,Wu C,Lou Z,Wang X,Ding J,Li Z,Xiao J,Xu H,Gao W,Zhou K

Sat May 01 00:00:00 EDT 2021

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.

PLoS neglected tropical diseases

Lam HYP,Liang TR,Peng SY

Tue Jun 01 00:00:00 EDT 2021

Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.

Biomedicines

Hsu YH,Zheng CM,Chou CL,Chen YJ,Lee YH,Lin YF,Chiu HW

Wed Apr 07 00:00:00 EDT 2021

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.

Frontiers in immunology

Que R,Zheng J,Chang Z,Zhang W,Li H,Xie Z,Huang Z,Wang HT,Xu J,Jin D,Yang W,Tan EK,Wang Q

Fri Mar 04 00:00:00 EST 2022

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.

Frontiers in immunology

Que R,Zheng J,Chang Z,Zhang W,Li H,Xie Z,Huang Z,Wang HT,Xu J,Jin D,Yang W,Tan EK,Wang Q

Fri Mar 04 00:00:00 EST 2022

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.

Frontiers in immunology

Que R,Zheng J,Chang Z,Zhang W,Li H,Xie Z,Huang Z,Wang HT,Xu J,Jin D,Yang W,Tan EK,Wang Q

Fri Mar 04 00:00:00 EST 2022

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.

Frontiers in immunology

Que R,Zheng J,Chang Z,Zhang W,Li H,Xie Z,Huang Z,Wang HT,Xu J,Jin D,Yang W,Tan EK,Wang Q

Fri Mar 04 00:00:00 EST 2022

Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.

Journal of cellular and molecular medicine

Han M,Li S,Li L

Mon May 24 00:00:00 EDT 2021

Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.

Journal of cellular and molecular medicine

Han M,Li S,Li L

Mon May 24 00:00:00 EDT 2021

Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Li F,Xu D,Hou K,Gou X,Lv N,Fang W,Li Y

Wed Dec 01 00:00:00 EST 2021

Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.

Frontiers in medicine

Li C,Zhu Y,Wu Y,Fu M,Wu Y,Wu Y,Qiu Y,Zhang H,Ding M

Tue Feb 01 00:00:00 EST 2022

Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.

Journal of translational medicine

Hu J,Qiao J,Yu Q,Liu B,Zhen J,Liu Y,Ma Q,Li Y,Wang Q,Wang C,Lv Z

Mon Feb 15 00:00:00 EST 2021

GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.

International journal of chronic obstructive pulmonary disease

Peng W,Wu Y,Zhang G,Zhu W,Chang M,Rouzi A,Jiang W,Tong L,Wang Q,Liu J,Song Y,Li H,Li K,Zhou J

Mon Nov 08 00:00:00 EST 2021

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.

Oxidative medicine and cellular longevity

Liao Z,Li S,Liu R,Feng X,Shi Y,Wang K,Li S,Zhang Y,Wu X,Yang C

Wed Dec 29 00:00:00 EST 2021

Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Journal of biochemical and molecular toxicology

Zhai J,Gao H,Wang S,Zhang S,Qu X,Zhang Y,Tao L,Sun J,Song Y,Fu L

Mon Nov 01 00:00:00 EDT 2021

Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.

International immunopharmacology

Huang J,An Q,Ju BM,Zhang J,Fan P,He L,Wang L

Mon Nov 01 00:00:00 EDT 2021

Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.

International immunopharmacology

Huang J,An Q,Ju BM,Zhang J,Fan P,He L,Wang L

Mon Nov 01 00:00:00 EDT 2021

Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation.

Frontiers in pharmacology

Li W,Zeng H,Xu M,Huang C,Tao L,Li J,Zhang T,Chen H,Xia J,Li C,Li X

Tue Aug 17 00:00:00 EDT 2021

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.

Frontiers in cell and developmental biology

Liu H,Zhang Y,Song W,Sun Y,Jiang Y

Tue Aug 31 00:00:00 EDT 2021

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.

Frontiers in cell and developmental biology

Liu H,Zhang Y,Song W,Sun Y,Jiang Y

Tue Aug 31 00:00:00 EDT 2021

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.

Frontiers in cell and developmental biology

Liu H,Zhang Y,Song W,Sun Y,Jiang Y

Tue Aug 31 00:00:00 EDT 2021

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.

International journal of molecular sciences

Ge S,Yang W,Chen H,Yuan Q,Liu S,Zhao Y,Zhang J

Wed Nov 17 00:00:00 EST 2021

Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression.

Brain, behavior, and immunity

Li W,Ali T,He K,Liu Z,Shah FA,Ren Q,Liu Y,Jiang A,Li S

Mon Feb 01 00:00:00 EST 2021

Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.

Free radical biology & medicine

Wei Z,Fei Y,Wang Q,Hou J,Cai X,Yang Y,Chen T,Xu Q,Wang Y,Li YG

Sat May 01 00:00:00 EDT 2021

Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.

Scientific reports

Fu F,Bao R,Yao S,Zhou C,Luo H,Zhang Z,Zhang H,Li Y,Yan S,Yu H,Du W,Yang Y,Jin H,Tong P,Sun ZT,Yue M,Chen D,Wu C,Ruan H

Tue Jan 12 00:00:00 EST 2021

Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.

International immunopharmacology

Wang X,Chen S,Zhao L,Shi X

Sun Aug 01 00:00:00 EDT 2021

MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.

Environmental science and pollution research international

Jiang L,Qiu T,Yao X,Chen H,Yao K,Sun X,Yang G,Jiang L,Zhang C,Wang N,Zhang H,Liu X

Wed Dec 01 00:00:00 EST 2021

Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.

International journal of molecular medicine

Guo H,Zhu L,Tang P,Chen D,Li Y,Li J,Bao C

Thu Apr 01 00:00:00 EDT 2021

lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.

International journal of molecular medicine

Dai W,Wang M,Wang P,Wen J,Wang J,Cha S,Xiao X,He Y,Shu R,Bai D

Mon Feb 01 00:00:00 EST 2021

Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.

Asian journal of pharmaceutical sciences

Tang W,Yang Y,Yang L,Tang M,Chen Y,Li C

Thu Jul 01 00:00:00 EDT 2021

Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.

Cellular signalling

Xu M,Ye Z,Zhao X,Guo H,Gong X,Huang R

Fri Oct 01 00:00:00 EDT 2021

Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.

Cellular signalling

Xu M,Ye Z,Zhao X,Guo H,Gong X,Huang R

Fri Oct 01 00:00:00 EDT 2021

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.

Journal of inflammation research

Fan W,Chen S,Wu X,Zhu J,Li J

Mon Apr 25 00:00:00 EDT 2022

Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.

Pharmaceutical biology

Lu B,Xie J,Fu D,Chen X,Zhao M,Gui M,Yao L,Zhou X,Li J

Wed Dec 01 00:00:00 EST 2021

Kupffer cell-targeting strategy for the protection of hepatic ischemia/reperfusion injury.

Nanotechnology

Dai Q,Jiang W,Liu H,Qing X,Wang G,Huang F,Yang Z,Wang C,Gu E,Zhao H,Zhang J,Liu X

Tue Apr 06 00:00:00 EDT 2021

Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.

Oncology reports

Zhu Z,Zhu Q,Cai D,Chen L,Xie W,Bai Y,Luo K

Tue Jun 01 00:00:00 EDT 2021

AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.

Frontiers in pharmacology

Kong L,Zhang H,Lu C,Shi K,Huang H,Zheng Y,Wang Y,Wang D,Wang H,Huang W

Sat Sep 18 00:00:00 EDT 2021

Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.

Frontiers in pharmacology

Feng B,Zhao X,Zhao W,Jiang H,Ren Z,Chen Y,Yuan Y,Du Z

Fri Nov 26 00:00:00 EST 2021

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.

Environmental toxicology

Wei J,Wang X,Liu Q,Zhou N,Zhu S,Li Z,Li X,Yao J,Zhang L

Sat May 01 00:00:00 EDT 2021

Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice.

Neuroscience letters

Li J,Tian S,Wang H,Wang Y,Du C,Fang J,Wang X,Wang Y,Gong Z,Yan B,Wang M

Sun Jan 10 00:00:00 EST 2021

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.

International journal of biological sciences

Yan H,Luo B,Wu X,Guan F,Yu X,Zhao L,Ke X,Wu J,Yuan J

Wed Mar 16 00:00:00 EDT 2022

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.

International journal of biological sciences

Yan H,Luo B,Wu X,Guan F,Yu X,Zhao L,Ke X,Wu J,Yuan J

Wed Mar 16 00:00:00 EDT 2022

MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.

International immunopharmacology

Liu Y,Liu Y,Wang Q,Song Y,Chen S,Cheng B,Zhang Y,Cui Z,Wu Z,Zhu C

Thu Jul 01 00:00:00 EDT 2021

MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.

International immunopharmacology

Liu Y,Liu Y,Wang Q,Song Y,Chen S,Cheng B,Zhang Y,Cui Z,Wu Z,Zhu C

Thu Jul 01 00:00:00 EDT 2021

Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wei YY,Fan YM,Ga Y,Zhang YN,Han JC,Hao ZH

Mon Nov 01 00:00:00 EDT 2021

Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wei YY,Fan YM,Ga Y,Zhang YN,Han JC,Hao ZH

Mon Nov 01 00:00:00 EDT 2021

H₂S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.

International journal of cardiology

Cui J,Xu G,Bian F

Wed Sep 01 00:00:00 EDT 2021

H₂S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.

International journal of cardiology

Cui J,Xu G,Bian F

Wed Sep 01 00:00:00 EDT 2021

H₂S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.

International journal of cardiology

Cui J,Xu G,Bian F

Wed Sep 01 00:00:00 EDT 2021

H₂S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.

International journal of cardiology

Cui J,Xu G,Bian F

Wed Sep 01 00:00:00 EDT 2021

Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.

Cell death discovery

Chen Y,Gong K,Guo L,Zhang B,Chen S,Li Z,Quanhua X,Liu W,Wang Z

Tue Oct 12 00:00:00 EDT 2021

Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.

Cell death discovery

Chen Y,Gong K,Guo L,Zhang B,Chen S,Li Z,Quanhua X,Liu W,Wang Z

Tue Oct 12 00:00:00 EDT 2021

CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.

General psychiatry

Wu J,Li J,Gaurav C,Muhammad U,Chen Y,Li X,Chen J,Wang Z

Fri Apr 29 00:00:00 EDT 2022

The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.

BioMed research international

Bai Y,Feng Y,Jiang B,Yang Y,Pei Z,Yang Q,Cui Y

Tue Sep 28 00:00:00 EDT 2021

Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.

BMC nephrology

Xu X,Huang X,Zhang L,Huang X,Qin Z,Hua F

Thu Jun 10 00:00:00 EDT 2021

Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood-Brain Barrier-Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats.

Frontiers in pharmacology

Lyu Z,Li Q,Yu Z,Chan Y,Fu L,Li Y,Zhang C

Tue Jan 04 00:00:00 EST 2022

Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.

International immunopharmacology

Wang L,Wang X,Kong L,Wang S,Huang K,Wu J,Wang C,Sun H,Liu K,Meng Q

Mon Nov 01 00:00:00 EDT 2021

Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.

Oxidative medicine and cellular longevity

Zhang Q,Zhao C,Zhang L,Sun K,Yu L,Wang X,Ren L,Zhang N,Chen C,Liu J,Wang H,Tian H

Tue Jan 11 00:00:00 EST 2022

Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.

Oxidative medicine and cellular longevity

Zhang Q,Zhao C,Zhang L,Sun K,Yu L,Wang X,Ren L,Zhang N,Chen C,Liu J,Wang H,Tian H

Tue Jan 11 00:00:00 EST 2022

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.

Oxidative medicine and cellular longevity

Zhu X,Hu X,Lou J,Li J,Xu Y,Yu G,Wu C,Ding J,Gao W,Xiao J,Zhou K,Jia C

Fri May 28 00:00:00 EDT 2021

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.

Oxidative medicine and cellular longevity

Zhu X,Hu X,Lou J,Li J,Xu Y,Yu G,Wu C,Ding J,Gao W,Xiao J,Zhou K,Jia C

Fri May 28 00:00:00 EDT 2021

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.

Journal of neuroinflammation

Chen J,Mao K,Yu H,Wen Y,She H,Zhang H,Liu L,Li M,Li W,Zou F

Mon Dec 20 00:00:00 EST 2021

Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.

Acta biochimica et biophysica Sinica

Dai J,Chen Q,Huang W,Shi K,Zhang Y,Li T,Mou T,Huang Z,Wu Z

Thu Apr 15 00:00:00 EDT 2021

Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.

Toxicology and applied pharmacology

Wang X,Liu K,Gong H,Li D,Chu W,Zhao D,Wang X,Xu D

Fri Jan 01 00:00:00 EST 2021

Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.

Cell death discovery

Li Z,Huang Z,Zhang H,Lu J,Tian Y,Piao S,Lin Z,Bai L

Wed Nov 10 00:00:00 EST 2021

Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.

Cell death discovery

Li Z,Huang Z,Zhang H,Lu J,Tian Y,Piao S,Lin Z,Bai L

Wed Nov 10 00:00:00 EST 2021

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.

Ecotoxicology and environmental safety

Hou J,Lei Z,Cui L,Hou Y,Yang L,An R,Wang Q,Li S,Zhang H,Zhang L

Thu Apr 01 00:00:00 EDT 2021

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.

Ecotoxicology and environmental safety

Hou J,Lei Z,Cui L,Hou Y,Yang L,An R,Wang Q,Li S,Zhang H,Zhang L

Thu Apr 01 00:00:00 EDT 2021

PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.

International journal of molecular medicine

Zeng J,Tao J,Xi L,Wang Z,Liu L

Thu Apr 01 00:00:00 EDT 2021

LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.

Frontiers in immunology

Ma X,Li Y,Shen W,Oladejo AO,Yang J,Jiang W,Imam BH,Wu X,Ding X,Yang Y,Wang S,Yan Z

Thu Oct 21 00:00:00 EDT 2021

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.

Experimental neurology

Liu X,Zhang M,Liu H,Zhu R,He H,Zhou Y,Zhang Y,Li C,Liang D,Zeng Q,Huang G

Thu Jul 01 00:00:00 EDT 2021

Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.

Toxicology and applied pharmacology

Zheng T,Wang Q,Bian F,Zhao Y,Ma W,Zhang Y,Lu W,Lei P,Zhang L,Hao X,Chen L

Thu Apr 01 00:00:00 EDT 2021

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.

BMC musculoskeletal disorders

Guo Z,Qiu C,Mecca C,Zhang Y,Bian J,Wang Y,Wu X,Wang T,Su W,Li X,Zhang W,Chen B,Xiang H

Wed Jan 13 00:00:00 EST 2021

Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Hao W,Hao C,Wu C,Xu Y,Wu S,Lu X,Yang J,Jin C

Mon Nov 01 00:00:00 EDT 2021

An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.

Iranian journal of pharmaceutical research : IJPR

Lam HYP,Hung MY,Liang TR,Peng SY

Thu Feb 24 00:00:00 EST 2022

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Asian journal of andrology

Yue XF,Shen CX,Wang JW,Dai LY,Fang Q,Long L,Zhi Y,Li XR,Wang YW,Shen GF,Liu ZJ,Shi CM,Li WB

Fri Dec 03 00:00:00 EST 2021

Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway.

Journal of inflammation research

Shen R,Yin P,Yao H,Chen L,Chang X,Li H,Hou X

Thu Apr 21 00:00:00 EDT 2022

Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.

Die Pharmazie

Zhuang J,Zhou X,Liu T,Zhang S,Yuan F,Zhang L,Yang Z,Chen Y

Mon Nov 01 00:00:00 EDT 2021

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chen LJ,Zhi X,Zhang KK,Wang LB,Li JH,Liu JL,Xu LL,Yoshida JS,Xie XL,Wang Q

Mon Feb 01 00:00:00 EST 2021

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.

Life sciences

Nie C,Ding X,A R,Zheng M,Li Z,Pan S,Yang W

Sat May 01 00:00:00 EDT 2021

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.

Life sciences

Nie C,Ding X,A R,Zheng M,Li Z,Pan S,Yang W

Sat May 01 00:00:00 EDT 2021

Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM_2.5.

Toxicology

Zhang X,Qi W,Shi Y,Li X,Yin J,Huo C,Zhang R,Zhao W,Ye J,Zhou L,Ye L

Wed Dec 01 00:00:00 EST 2021

NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis.

Biochimica et biophysica acta. Molecular basis of disease

Ji J,Hou J,Xia Y,Xiang Z,Han X

Sat May 01 00:00:00 EDT 2021

Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.

International journal of biological sciences

Wu C,Chen H,Zhuang R,Zhang H,Wang Y,Hu X,Xu Y,Li J,Li Y,Wang X,Xu H,Ni W,Zhou K

Fri Jan 21 00:00:00 EST 2022

Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway.

Scientific reports

Wang D,Zou J,Dai J,Cheng Z

Thu Apr 15 00:00:00 EDT 2021

Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury.

Frontiers in pharmacology

Dai C,Liu B,Peng B,Qu B,Lin J,Peng B,Li DM

Wed Dec 15 00:00:00 EST 2021

Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury.

Frontiers in pharmacology

Dai C,Liu B,Peng B,Qu B,Lin J,Peng B,Li DM

Wed Dec 15 00:00:00 EST 2021

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.

Oxidative medicine and cellular longevity

Zhu JJ,Yu BY,Huang XK,He MZ,Chen BW,Chen TT,Fang HY,Chen SQ,Fu XQ,Li PJ,Lin ZL,Zhu JH

Wed Nov 24 00:00:00 EST 2021

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.

Oxidative medicine and cellular longevity

Zhu JJ,Yu BY,Huang XK,He MZ,Chen BW,Chen TT,Fang HY,Chen SQ,Fu XQ,Li PJ,Lin ZL,Zhu JH

Wed Nov 24 00:00:00 EST 2021

DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.

Experimental and therapeutic medicine

Feng D,Guo L,Liu J,Song Y,Ma X,Hu H,Liu J,Hao E

Wed Dec 01 00:00:00 EST 2021

N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.

Experimental eye research

Liu J,Zhang N,Zhang M,Yin H,Zhang X,Wang X,Wang X,Zhao Y

Thu Jul 01 00:00:00 EDT 2021

N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.

Experimental eye research

Liu J,Zhang N,Zhang M,Yin H,Zhang X,Wang X,Wang X,Zhao Y

Thu Jul 01 00:00:00 EDT 2021

Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.

Frontiers in cardiovascular medicine

Yu YW,Que JQ,Liu S,Huang KY,Qian L,Weng YB,Rong FN,Wang L,Zhou YY,Xue YJ,Ji KT

Fri Jan 28 00:00:00 EST 2022

Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.

BioMed research international

Liu L,Zhai K,Chen Y,Chen X,Wang G,Wu L

Fri May 28 00:00:00 EDT 2021

Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.

ACS nano

Liao Z,Liu H,Ma L,Lei J,Tong B,Li G,Ke W,Wang K,Feng X,Hua W,Li S,Yang C

Tue Sep 28 00:00:00 EDT 2021

LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.

Cellular and molecular neurobiology

Zhang Q,Huang XM,Liao JX,Dong YK,Zhu JL,He CC,Huang J,Tang YW,Wu D,Tian JY

Mon Nov 01 00:00:00 EDT 2021

PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.

American journal of translational research

Ge X,Cai F,Shang Y,Chi F,Xiao H,Xu J,Fu Y,Bai C

Wed Feb 03 00:00:00 EST 2021

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.

Stem cell research & therapy

Cai X,Zhang ZY,Yuan JT,Ocansey DKW,Tu Q,Zhang X,Qian H,Xu WR,Qiu W,Mao F

Thu Jul 22 00:00:00 EDT 2021

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.

Stem cell research & therapy

Cai X,Zhang ZY,Yuan JT,Ocansey DKW,Tu Q,Zhang X,Qian H,Xu WR,Qiu W,Mao F

Thu Jul 22 00:00:00 EDT 2021

IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.

Experimental and therapeutic medicine

Wang J,Yuan X,Ding N

Tue Jun 01 00:00:00 EDT 2021

ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.

Pharmacological research

Kong X,Chen R,Zhang L,Wu M,Wu J,Wei Y,Dai W,Jiang Y

Wed Dec 01 00:00:00 EST 2021

Airborne particulate matter (PM_2.5) triggers ocular hypertension and glaucoma through pyroptosis.

Particle and fibre toxicology

Li L,Xing C,Zhou J,Niu L,Luo B,Song M,Niu J,Ruan Y,Sun X,Lei Y

Thu Mar 04 00:00:00 EST 2021

Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.

Atherosclerosis

Xu S,Chen H,Ni H,Dai Q

Fri Jan 01 00:00:00 EST 2021

Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.

Atherosclerosis

Xu S,Chen H,Ni H,Dai Q

Fri Jan 01 00:00:00 EST 2021

MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.

Signal transduction and targeted therapy

Tang Q,Li W,Zheng X,Ren L,Liu J,Li S,Wang J,Du G

Wed Dec 02 00:00:00 EST 2020

Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.

DNA and cell biology

Chen JJ,Tao J,Zhang XL,Xia LZ,Zeng JF,Zhang H,Wei DH,Lv YC,Li GH,Wang Z

Wed Apr 01 00:00:00 EDT 2020

Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.

Drug design, development and therapy

Gao Z,Sui J,Fan R,Qu W,Dong X,Sun D

Mon Mar 29 00:00:00 EDT 2021

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

Biochemical and biophysical research communications

Zhang X,Li F,Wang W,Ji L,Sun B,Xiao X,Wang X,Chen Y,Liu B,Ye W,Tian C,Wang H,Zheng Y

Thu Dec 17 00:00:00 EST 2020

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

Biochemical and biophysical research communications

Zhang X,Li F,Wang W,Ji L,Sun B,Xiao X,Wang X,Chen Y,Liu B,Ye W,Tian C,Wang H,Zheng Y

Thu Dec 17 00:00:00 EST 2020

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

Biochemical and biophysical research communications

Zhang X,Li F,Wang W,Ji L,Sun B,Xiao X,Wang X,Chen Y,Liu B,Ye W,Tian C,Wang H,Zheng Y

Thu Dec 17 00:00:00 EST 2020

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

Biochemical and biophysical research communications

Zhang X,Li F,Wang W,Ji L,Sun B,Xiao X,Wang X,Chen Y,Liu B,Ye W,Tian C,Wang H,Zheng Y

Thu Dec 17 00:00:00 EST 2020

Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.

Frontiers in pharmacology

Jin H,Zhao Z,Lan Q,Zhou H,Mai Z,Wang Y,Ding X,Zhang W,Pi J,Evans CE,Liu X

Tue Feb 16 00:00:00 EST 2021

Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome.

Molecular medicine reports

Hu Y,Wang X,Li Q,Pan Y,Xu L

Tue Dec 01 00:00:00 EST 2020

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.

EBioMedicine

Luo X,Li Y,Yang P,Chen Y,Wei L,Yu T,Xia J,Ruan XZ,Zhao L,Chen Y

Mon Jun 01 00:00:00 EDT 2020

Trimethylamine N-oxide promotes apoE^-/- mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.

Journal of cellular physiology

Wu P,Chen J,Chen J,Tao J,Wu S,Xu G,Wang Z,Wei D,Yin W

Thu Oct 01 00:00:00 EDT 2020

Trimethylamine N-oxide promotes apoE^-/- mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.

Journal of cellular physiology

Wu P,Chen J,Chen J,Tao J,Wu S,Xu G,Wang Z,Wei D,Yin W

Thu Oct 01 00:00:00 EDT 2020

A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.

Neurochemical research

Wang YH,Li Y,Wang JN,Zhao QX,Wen S,Wang SC,Sun T

Sat Aug 01 00:00:00 EDT 2020

A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.

Neurochemical research

Wang YH,Li Y,Wang JN,Zhao QX,Wen S,Wang SC,Sun T

Sat Aug 01 00:00:00 EDT 2020

Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux.

Frontiers in cellular neuroscience

Zeng Q,Zhou Y,Liang D,He H,Liu X,Zhu R,Zhang M,Luo X,Wang Y,Huang G

Mon Sep 28 00:00:00 EDT 2020

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.

Cellular & molecular immunology

He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

Sun Mar 01 00:00:00 EST 2020

Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.

Cancer management and research

Luo W,Han Y,Meng P,Yang Q,Zhao H,Ling J,Wang Y

Tue Apr 19 00:00:00 EDT 2022

α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.

Experimental and therapeutic medicine

Wang X,Chi J,Huang D,Ding L,Zhao X,Jiang L,Yu Y,Gao F

Sat Feb 01 00:00:00 EST 2020

Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.

Ecotoxicology and environmental safety

Li S,Shi M,Wan Y,Wang Y,Zhu M,Wang B,Zhan Y,Ran B,Wu C

Tue Sep 15 00:00:00 EDT 2020

Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.

BMC infectious diseases

Wang L,Wang D,Wu X,Xu R,Li Y

Wed Nov 11 00:00:00 EST 2020

Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages.

Cell death & disease

Zhang C,Zhao C,Chen X,Tao R,Wang S,Meng G,Liu X,Shao C,Su X

Thu Jun 18 00:00:00 EDT 2020

Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.

BioMed research international

Guo LP,Liu SX,Yang Q,Liu HY,Xu LL,Hao YH,Zhang XQ

Thu Jul 09 00:00:00 EDT 2020

Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.

BioMed research international

Guo LP,Liu SX,Yang Q,Liu HY,Xu LL,Hao YH,Zhang XQ

Thu Jul 09 00:00:00 EDT 2020

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.

Frontiers in pharmacology

Jiang M,Wang W,Zhang J,Wang C,Bi Y,Li P,Yang S,Li J,Xu YT,Wang T

Thu Apr 14 00:00:00 EDT 2022

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.

Frontiers in pharmacology

Jiang M,Wang W,Zhang J,Wang C,Bi Y,Li P,Yang S,Li J,Xu YT,Wang T

Thu Apr 14 00:00:00 EDT 2022

Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.

Behavioural brain research

Liu Q,Guo X,Huang Z,He Q,Zhu D,Zhang S,Peng Z,Che Y,Feng X

Mon Apr 06 00:00:00 EDT 2020

Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.

Free radical biology & medicine

Zhou Y,Wang S,Wan T,Huang Y,Pang N,Jiang X,Gu Y,Zhang Z,Luo J,Yang L

Fri Nov 20 00:00:00 EST 2020

Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.

Frontiers in neuroscience

Wang YH,Li Y,Wang JN,Zhao QX,Jin J,Wen S,Wang SC,Sun T

Sun Apr 17 00:00:00 EDT 2022

Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.

Oxidative medicine and cellular longevity

He XM,Zhou YZ,Sheng S,Li JJ,Wang GQ,Zhang F

Tue Jun 08 00:00:00 EDT 2021

VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.

Oxidative medicine and cellular longevity

Sun Z,Nyanzu M,Yang S,Zhu X,Wang K,Ru J,Yu E,Zhang H,Wang Z,Shen J,Zhuge Q,Huang L

Thu Feb 04 00:00:00 EST 2021

LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.

Cell cycle (Georgetown, Tex.)

Xu Y,Fang H,Xu Q,Xu C,Yang L,Huang C

Sun Nov 01 00:00:00 EDT 2020

Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.

Scientific reports

Tan S,Gao J,Li Q,Guo T,Dong X,Bai X,Yang J,Hao S,He F

Tue Nov 17 00:00:00 EST 2020

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.

Journal of neuroinflammation

Chang Y,Zhu J,Wang D,Li H,He Y,Liu K,Wang X,Peng Y,Pan S,Huang K

Thu Jul 23 00:00:00 EDT 2020

1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.

Biochemical pharmacology

Zhou Y,Fu X,Guan Y,Gong M,He K,Huang B

Sat Feb 01 00:00:00 EST 2020

Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.

Cytokine

Yang K,Zhan L,Lu T,Zhou C,Chen X,Dong Y,Lv G,Chen S

Thu Mar 26 00:00:00 EDT 2020

Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.

Parasitology international

Lam HYP,Chen TT,Chen CC,Yang TH,Cheng PC,Peng SY

Sat Aug 01 00:00:00 EDT 2020

Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice.

Food & function

Yang R,Li Y,Cai J,Ji J,Wang Y,Zhang W,Pan W,Chen Y

Wed Nov 18 00:00:00 EST 2020

Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.

European journal of medicinal chemistry

Pang H,Wang N,Chai J,Wang X,Zhang Y,Bi Z,Wu W,He G

Wed Jul 01 00:00:00 EDT 2020

Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.

Biomolecules

Lam HYP,Liang TR,Jiang SJ,Peng SY

Sun Jul 05 00:00:00 EDT 2020

FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.

Experimental cell research

Zeng Z,Zheng Q,Chen J,Tan X,Li Q,Ding L,Zhang R,Lin X

Sat Aug 15 00:00:00 EDT 2020

Latcripin-7A, derivative of Lentinula edodes C_91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G₁ phase in breast cancer cells.

Applied microbiology and biotechnology

Din SRU,Zhong M,Nisar MA,Saleem MZ,Hussain A,Khinsar KH,Alam S,Ayub G,Kanwal S,Li X,Zhang W,Wang X,Ning A,Cao J,Huang M

Tue Dec 01 00:00:00 EST 2020

Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.

American journal of reproductive immunology (New York, N.Y. : 1989)

Chudnovets A,Lei J,Na Q,Dong J,Narasimhan H,Klein SL,Burd I

Wed Jul 01 00:00:00 EDT 2020

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.

Aging

Bai Z,Liu W,He D,Wang Y,Yi W,Luo C,Shen J,Hu Z

Wed Apr 22 00:00:00 EDT 2020

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.

Aging

Bai Z,Liu W,He D,Wang Y,Yi W,Luo C,Shen J,Hu Z

Wed Apr 22 00:00:00 EDT 2020

Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.

Life sciences

Zheng X,Zhong T,Ma Y,Wan X,Qin A,Yao B,Zou H,Song Y,Yin D

Sat Feb 01 00:00:00 EST 2020

Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.

International journal of clinical and experimental pathology

Wu X,Mao X,Huang Y,Zhu Q,Guan J,Wu L

Wed Jul 15 00:00:00 EDT 2020

Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.

Frontiers in aging neuroscience

Zhang J,Pei L,Zang D,Xue Y,Wang X,Chen Y,Li J,Yu J,Gao Q,Di W,Cui C,Su W,Wang X

Fri Dec 18 00:00:00 EST 2020

Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.

Frontiers in aging neuroscience

Zhang J,Pei L,Zang D,Xue Y,Wang X,Chen Y,Li J,Yu J,Gao Q,Di W,Cui C,Su W,Wang X

Fri Dec 18 00:00:00 EST 2020

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.

Free radical biology & medicine

Kai J,Yang X,Wang Z,Wang F,Jia Y,Wang S,Tan S,Chen A,Shao J,Zhang F,Zhang Z,Zheng S

Mon Jun 01 00:00:00 EDT 2020

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.

Free radical biology & medicine

Kai J,Yang X,Wang Z,Wang F,Jia Y,Wang S,Tan S,Chen A,Shao J,Zhang F,Zhang Z,Zheng S

Mon Jun 01 00:00:00 EDT 2020

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.

Free radical biology & medicine

Kai J,Yang X,Wang Z,Wang F,Jia Y,Wang S,Tan S,Chen A,Shao J,Zhang F,Zhang Z,Zheng S

Mon Jun 01 00:00:00 EDT 2020

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.

Free radical biology & medicine

Kai J,Yang X,Wang Z,Wang F,Jia Y,Wang S,Tan S,Chen A,Shao J,Zhang F,Zhang Z,Zheng S

Mon Jun 01 00:00:00 EDT 2020

MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Wang QS,Luo XY,Fu H,Luo Q,Wang MQ,Zou DY

Tue Sep 01 00:00:00 EDT 2020

Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.

Frontiers in pharmacology

Wei C,Guo S,Liu W,Jin F,Wei B,Fan H,Su H,Liu J,Zhang N,Fang D,Li G,Shu S,Li X,He X,Zhang X,Duan C

Sat Mar 20 00:00:00 EDT 2021

Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.

International journal of biological macromolecules

Yang K,Lu T,Zhan L,Zhou C,Zhang N,Lei S,Wang Y,Yang J,Yan M,Lv G,Chen S

Wed Apr 15 00:00:00 EDT 2020

Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.

Journal of cellular and molecular medicine

Zhang J,Zhang J,Zhang Y,Liu W,Ni W,Huang X,Yuan J,Zhao B,Xiao H,Xue F

Thu Oct 01 00:00:00 EDT 2020

Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.

Frontiers in cellular neuroscience

Du P,Wang J,Han Y,Feng J

Mon Sep 28 00:00:00 EDT 2020

MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.

Placenta

Tao J,Xia LZ,Liang L,Chen Y,Wei D,Meng J,Wu S,Wang Z

Sun Nov 01 00:00:00 EDT 2020

H₂S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.

Experimental cell research

Zhou Y,Zhu X,Wang X,Peng Y,Du J,Yin H,Yang H,Ni X,Zhang W

Sat Feb 01 00:00:00 EST 2020

Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.

The Science of the total environment

Wang D,Weng Y,Zhang Y,Wang R,Wang T,Zhou J,Shen S,Wang H,Wang Y

Wed Nov 25 00:00:00 EST 2020

RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.

Journal of agricultural and food chemistry

Liu N,Wang Y,Zeng L,Yin S,Hu Y,Li S,Fu Y,Zhang X,Xie C,Shu L,Li Y,Sun H,Yang M,Sun J,Yang X

Wed Jul 08 00:00:00 EDT 2020

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

Pharmacological research

Zhu Y,Zhu C,Yang H,Deng J,Fan D

Fri May 01 00:00:00 EDT 2020

Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.

Journal of hazardous materials

Xie C,Ge M,Jin J,Xu H,Mao L,Geng S,Wu J,Zhu J,Li X,Zhong C

Wed Jul 15 00:00:00 EDT 2020

Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.

Journal of hazardous materials

Xie C,Ge M,Jin J,Xu H,Mao L,Geng S,Wu J,Zhu J,Li X,Zhong C

Wed Jul 15 00:00:00 EDT 2020

Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.

Frontiers in pharmacology

Li N,Zhao T,Cao Y,Zhang H,Peng L,Wang Y,Zhou X,Wang Q,Li J,Yan M,Dong X,Zhao H,Li P

Tue Feb 16 00:00:00 EST 2021

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.

Redox biology

Jia Y,Cui R,Wang C,Feng Y,Li Z,Tong Y,Qu K,Liu C,Zhang J

Fri May 01 00:00:00 EDT 2020

A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.

European journal of pharmacology

Nie Q,Zhang J,He B,Wang F,Sun M,Wang C,Sun W,Guo J,Wen J,Liu P

Thu Nov 05 00:00:00 EST 2020

The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.

Drug development research

Wang G,Zuo T,Li R

Sun Nov 01 00:00:00 EDT 2020

Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R^-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects.

BioMed research international

Pei ZW,Guo Y,Zhu HL,Dong M,Zhang Q,Wang F

Tue May 04 00:00:00 EDT 2021

GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

International immunopharmacology

Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

Tue Dec 01 00:00:00 EST 2020

GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

International immunopharmacology

Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

Tue Dec 01 00:00:00 EST 2020

LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.

Cell proliferation

Ma M,Pei Y,Wang X,Feng J,Zhang Y,Gao MQ

Tue Jan 01 00:00:00 EST 2019

OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.

Journal of cellular physiology

Zhaolin Z,Jiaojiao C,Peng W,Yami L,Tingting Z,Jun T,Shiyuan W,Jinyan X,Dangheng W,Zhisheng J,Zuo W

Wed May 01 00:00:00 EDT 2019

OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.

Journal of cellular physiology

Zhaolin Z,Jiaojiao C,Peng W,Yami L,Tingting Z,Jun T,Shiyuan W,Jinyan X,Dangheng W,Zhisheng J,Zuo W

Wed May 01 00:00:00 EDT 2019

OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.

Journal of cellular physiology

Zhaolin Z,Jiaojiao C,Peng W,Yami L,Tingting Z,Jun T,Shiyuan W,Jinyan X,Dangheng W,Zhisheng J,Zuo W

Wed May 01 00:00:00 EDT 2019

OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.

Journal of cellular physiology

Zhaolin Z,Jiaojiao C,Peng W,Yami L,Tingting Z,Jun T,Shiyuan W,Jinyan X,Dangheng W,Zhisheng J,Zuo W

Wed May 01 00:00:00 EDT 2019

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.

Inflammation

Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z

Mon Apr 01 00:00:00 EDT 2019

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.

Inflammation

Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z

Mon Apr 01 00:00:00 EDT 2019

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.

Inflammation

Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z

Mon Apr 01 00:00:00 EDT 2019

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.

Inflammation

Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z

Mon Apr 01 00:00:00 EDT 2019

Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.

Toxicology letters

Du L,Shen K,Bai Y,Chao J,Hu G,Zhang Y,Yao H

Fri Feb 01 00:00:00 EST 2019

Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.

Toxicology letters

Du L,Shen K,Bai Y,Chao J,Hu G,Zhang Y,Yao H

Fri Feb 01 00:00:00 EST 2019

Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.

Oncology reports

Zhang Q,Tao X,Xia S,Qu J,Song H,Liu J,Li H,Shang D

Tue Jan 01 00:00:00 EST 2019

Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.

Oncology reports

Zhang Q,Tao X,Xia S,Qu J,Song H,Liu J,Li H,Shang D

Tue Jan 01 00:00:00 EST 2019

Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.

Ocular immunology and inflammation

Hao J,Zhang H,Yu J,Chen X,Yang L

Tue Jan 07 00:00:00 EST 2020

Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.

Ocular immunology and inflammation

Hao J,Zhang H,Yu J,Chen X,Yang L

Tue Jan 07 00:00:00 EST 2020

Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.

Biochemical and biophysical research communications

Wang J,Gong S,Wang F,Niu M,Wei G,He Z,Gu T,Jiang Y,Liu A,Chen P

Tue Jan 22 00:00:00 EST 2019

Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.

Biochemical and biophysical research communications

Wang J,Gong S,Wang F,Niu M,Wei G,He Z,Gu T,Jiang Y,Liu A,Chen P

Tue Jan 22 00:00:00 EST 2019

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.

Mediators of inflammation

Leng B,Zhang Y,Liu X,Zhang Z,Liu Y,Wang H,Lu M

Mon Jul 22 00:00:00 EDT 2019

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.

Biochemical and biophysical research communications

Wang X,Bian Y,Zhang R,Liu X,Ni L,Ma B,Zeng R,Zhao Z,Song X,Liu C

Tue Nov 05 00:00:00 EST 2019

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.

Biochemical and biophysical research communications

Wang X,Bian Y,Zhang R,Liu X,Ni L,Ma B,Zeng R,Zhao Z,Song X,Liu C

Tue Nov 05 00:00:00 EST 2019

Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.

Plant foods for human nutrition (Dordrecht, Netherlands)

Dia VP,Bradwell J,Pangloli P

Sun Sep 01 00:00:00 EDT 2019

Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.

Journal of cellular physiology

Huang Y,Wan T,Pang N,Zhou Y,Jiang X,Li B,Gu Y,Huang Y,Ye X,Lian H,Zhang Z,Yang L

Fri Nov 01 00:00:00 EDT 2019

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.

Cell death & disease

Wang K,Xu T,Ruan H,Xiao H,Liu J,Song Z,Cao Q,Bao L,Liu D,Wang C,Cheng G,Liang H,Chen Z,Yang H,Chen K,Zhang X

Fri Feb 15 00:00:00 EST 2019

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.

Redox biology

Li N,Zhou H,Wu H,Wu Q,Duan M,Deng W,Tang Q

Sat Jun 01 00:00:00 EDT 2019

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.

Redox biology

Li N,Zhou H,Wu H,Wu Q,Duan M,Deng W,Tang Q

Sat Jun 01 00:00:00 EDT 2019

Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.

Oxidative medicine and cellular longevity

Zheng GH,Shan Q,Mu JJ,Wang YJ,Zhang ZF,Fan SH,Hu B,Li MQ,Xie J,Chen P,Wu DM,Lu J,Zheng YL

Mon Mar 25 00:00:00 EDT 2019

MicroRNA-135b alleviates MPP⁺-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Zeng R,Luo DX,Li HP,Zhang QS,Lei SS,Chen JH

Mon Jul 01 00:00:00 EDT 2019

Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hou C,Zhu X,Shi C,Peng Y,Huang D,Li Q,Miao Y

Fri Nov 01 00:00:00 EDT 2019

Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang G,Jiang C,Xie N,Xu Y,Liu L,Liu N

Sun Sep 01 00:00:00 EDT 2019

UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.

Molecular immunology

Li C,Wang X,Kuang M,Li L,Wang Y,Yang F,Wang G

Thu Aug 01 00:00:00 EDT 2019

UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.

Molecular immunology

Li C,Wang X,Kuang M,Li L,Wang Y,Yang F,Wang G

Thu Aug 01 00:00:00 EDT 2019

Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lin Y,Wang S,Yang Z,Gao L,Zhou Z,Yu P,Wu B

Thu Aug 01 00:00:00 EDT 2019

Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.

Free radical biology & medicine

Li XX,Ling SK,Hu MY,Ma Y,Li Y,Huang PL

Sun Dec 01 00:00:00 EST 2019

Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.

Free radical biology & medicine

Li XX,Ling SK,Hu MY,Ma Y,Li Y,Huang PL

Sun Dec 01 00:00:00 EST 2019

Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3.

Chinese journal of traumatology = Zhonghua chuang shang za zhi

Peng J,Zhang P,Zheng H,Ren YQ,Yan H

Sat Jun 01 00:00:00 EDT 2019

The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.

International immunopharmacology

Qu J,Yuan Z,Wang G,Wang X,Li K

Wed May 01 00:00:00 EDT 2019

Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.

Frontiers in neuroscience

Zhuang K,Zuo YC,Sherchan P,Wang JK,Yan XX,Liu F

Mon Sep 28 00:00:00 EDT 2020

Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.

Frontiers in immunology

Chen C,Wei YZ,He XM,Li DD,Wang GQ,Li JJ,Zhang F

Wed Sep 09 00:00:00 EDT 2020

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways.

International journal of molecular sciences

Wang Y,Lin Z,Zhang B,Jiang Z,Guo F,Yang T

Fri Oct 04 00:00:00 EDT 2019

Porous Se@SiO₂ nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.

International journal of nanomedicine

Zheng Z,Deng G,Qi C,Xu Y,Liu X,Zhao Z,Zhang Z,Chu Y,Wu H,Liu J

Tue Feb 12 00:00:00 EST 2019

Porous Se@SiO₂ nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.

International journal of nanomedicine

Zheng Z,Deng G,Qi C,Xu Y,Liu X,Zhao Z,Zhang Z,Chu Y,Wu H,Liu J

Tue Feb 12 00:00:00 EST 2019

Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.

European journal of pharmacology

Yu X,Hao M,Liu Y,Ma X,Lin W,Xu Q,Zhou H,Shao N,Kuang H

Sun Dec 01 00:00:00 EST 2019

Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.

iScience

Qi H,Gao Y,Li Y,Wei J,Su X,Zhang C,Liu Y,Zhu H,Sui L,Xiong Y,Yang X,Xu Y,Zhang Y,Yang R

Fri Nov 22 00:00:00 EST 2019

Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.

Frontiers in physiology

Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

Sun Apr 10 00:00:00 EDT 2022

NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.

OncoTargets and therapy

Liu SG,Wu XX,Hua T,Xin XY,Feng DL,Chi SQ,Wang XX,Wang HB

Mon Apr 11 00:00:00 EDT 2022

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.

Cell death & disease

Wang Z,Zhou L,An D,Xu W,Wu C,Sha S,Li Y,Zhu Y,Chen A,Du Y,Chen L,Chen L

Thu May 16 00:00:00 EDT 2019

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.

Vascular pharmacology

Zang YH,Chen D,Zhou B,Chen AD,Wang JJ,Gao XY,Chen Q,Li YH,Kang YM,Zhu GQ

Tue Oct 01 00:00:00 EDT 2019

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Nature neuroscience

Fang EF,Hou Y,Palikaras K,Adriaanse BA,Kerr JS,Yang B,Lautrup S,Hasan-Olive MM,Caponio D,Dan X,Rocktäschel P,Croteau DL,Akbari M,Greig NH,Fladby T,Nilsen H,Cader MZ,Mattson MP,Tavernarakis N,Bohr VA

Fri Mar 01 00:00:00 EST 2019

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.

Frontiers in endocrinology

Wang Y,Zhu X,Yuan S,Wen S,Liu X,Wang C,Qu Z,Li J,Liu H,Sun L,Liu F

Wed Oct 23 00:00:00 EDT 2019

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.

Cell death & disease

Jia C,Zhang J,Chen H,Zhuge Y,Chen H,Qian F,Zhou K,Niu C,Wang F,Qiu H,Wang Z,Xiao J,Rong X,Chu M

Mon Oct 14 00:00:00 EDT 2019

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.

Cell death & disease

Jia C,Zhang J,Chen H,Zhuge Y,Chen H,Qian F,Zhou K,Niu C,Wang F,Qiu H,Wang Z,Xiao J,Rong X,Chu M

Mon Oct 14 00:00:00 EDT 2019

Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.

International immunopharmacology

Deng G,Chen W,Wang P,Zhan T,Zheng W,Gu Z,Wang X,Ji X,Sun Y

Sun Sep 01 00:00:00 EDT 2019

Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.

International immunopharmacology

Deng G,Chen W,Wang P,Zhan T,Zheng W,Gu Z,Wang X,Ji X,Sun Y

Sun Sep 01 00:00:00 EDT 2019

NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.

Life sciences

Wang H,Zhong D,Chen H,Jin J,Liu Q,Li G

Sat Jun 15 00:00:00 EDT 2019

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Tang YS,Zhao YH,Zhong Y,Li XZ,Pu JX,Luo YC,Zhou QL

Sun Sep 01 00:00:00 EDT 2019

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Tang YS,Zhao YH,Zhong Y,Li XZ,Pu JX,Luo YC,Zhou QL

Sun Sep 01 00:00:00 EDT 2019

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Tang YS,Zhao YH,Zhong Y,Li XZ,Pu JX,Luo YC,Zhou QL

Sun Sep 01 00:00:00 EDT 2019

Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.

Cells

Inoue T,Yamakage H,Tanaka M,Kusakabe T,Shimatsu A,Satoh-Asahara N

Fri May 31 00:00:00 EDT 2019

Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.

Nephron

Ma X,Chang Y,Xiong Y,Wang Z,Wang X,Xu Q

Mon Jun 29 00:00:00 EDT 2020

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.

Oxidative medicine and cellular longevity

Zheng T,Yang X,Li W,Wang Q,Chen L,Wu D,Bian F,Xing S,Jin S

Fri Oct 26 00:00:00 EDT 2018

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.

Oxidative medicine and cellular longevity

Zheng T,Yang X,Li W,Wang Q,Chen L,Wu D,Bian F,Xing S,Jin S

Fri Oct 26 00:00:00 EDT 2018

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.

Frontiers in endocrinology

Zhou F,Zhang Y,Chen J,Hu Y,Xu Y

Wed Nov 20 00:00:00 EST 2019

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.

Frontiers in endocrinology

Zhou F,Zhang Y,Chen J,Hu Y,Xu Y

Wed Nov 20 00:00:00 EST 2019

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.

Journal of molecular endocrinology

Song S,Qiu D,Luo F,Wei J,Wu M,Wu H,Du C,Du Y,Ren Y,Chen N,Duan H,Shi Y

Mon Oct 01 00:00:00 EDT 2018

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.

Journal of molecular endocrinology

Song S,Qiu D,Luo F,Wei J,Wu M,Wu H,Du C,Du Y,Ren Y,Chen N,Duan H,Shi Y

Mon Oct 01 00:00:00 EDT 2018

Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.

American journal of translational research

Du Y,Gu X,Meng H,Aa N,Liu S,Peng C,Ge Y,Yang Z

Wed Sep 30 00:00:00 EDT 2020

Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.

American journal of translational research

Du Y,Gu X,Meng H,Aa N,Liu S,Peng C,Ge Y,Yang Z

Wed Sep 30 00:00:00 EDT 2020

Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.

Immunobiology

Jiang Y,Yang W,Gui S

Mon Oct 01 00:00:00 EDT 2018

Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.

Immunobiology

Jiang Y,Yang W,Gui S

Mon Oct 01 00:00:00 EDT 2018

2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.

Experimental and therapeutic medicine

Han M,Zhang T,Gu W,Yang X,Zhao R,Yu J

Wed Aug 01 00:00:00 EDT 2018

2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.

Experimental and therapeutic medicine

Han M,Zhang T,Gu W,Yang X,Zhao R,Yu J

Wed Aug 01 00:00:00 EDT 2018

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 EDT 2018

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 EDT 2018

Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.

Frontiers in physiology

Qiu H,Ji C,Liu W,Wu Y,Lu Z,Lin Q,Xue Z,Liu X,Wu H,Jiang W,Zou C

Tue Sep 29 00:00:00 EDT 2020

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.

Frontiers in microbiology

Wu Q,Zhu YH,Xu J,Liu X,Duan C,Wang MJ,Wang JF

Wed Sep 30 00:00:00 EDT 2020

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.

Frontiers in microbiology

Wu Q,Zhu YH,Xu J,Liu X,Duan C,Wang MJ,Wang JF

Wed Sep 30 00:00:00 EDT 2020

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.

Frontiers in microbiology

Wu Q,Zhu YH,Xu J,Liu X,Duan C,Wang MJ,Wang JF

Wed Sep 30 00:00:00 EDT 2020

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.

Frontiers in microbiology

Wu Q,Zhu YH,Xu J,Liu X,Duan C,Wang MJ,Wang JF

Wed Sep 30 00:00:00 EDT 2020

Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Qiu H,Liu W,Lan T,Pan W,Chen X,Wu H,Xu D

Sat Dec 01 00:00:00 EST 2018

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhong H,Liu M,Ji Y,Ma M,Chen K,Liang T,Liu C

Tue Oct 16 00:00:00 EDT 2018

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhong H,Liu M,Ji Y,Ma M,Chen K,Liang T,Liu C

Tue Oct 16 00:00:00 EDT 2018

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.

Cell death & disease

Wu X,Zhang H,Qi W,Zhang Y,Li J,Li Z,Lin Y,Bai X,Liu X,Chen X,Yang H,Xu C,Zhang Y,Yang B

Wed Feb 07 00:00:00 EST 2018

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.

Cell death & disease

Wu X,Zhang H,Qi W,Zhang Y,Li J,Li Z,Lin Y,Bai X,Liu X,Chen X,Yang H,Xu C,Zhang Y,Yang B

Wed Feb 07 00:00:00 EST 2018

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.

Cell death & disease

Wu X,Zhang H,Qi W,Zhang Y,Li J,Li Z,Lin Y,Bai X,Liu X,Chen X,Yang H,Xu C,Zhang Y,Yang B

Wed Feb 07 00:00:00 EST 2018

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.

Cell death & disease

Wu X,Zhang H,Qi W,Zhang Y,Li J,Li Z,Lin Y,Bai X,Liu X,Chen X,Yang H,Xu C,Zhang Y,Yang B

Wed Feb 07 00:00:00 EST 2018

Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling.

Chemical research in toxicology

Dong W,Yang B,Wang Y,Yuan J,Fan Y,Song E,Song Y

Mon Nov 19 00:00:00 EST 2018

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.

Nature communications

Wang S,Lin Y,Yuan X,Li F,Guo L,Wu B

Fri Oct 12 00:00:00 EDT 2018

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.

Nature communications

Wang S,Lin Y,Yuan X,Li F,Guo L,Wu B

Fri Oct 12 00:00:00 EDT 2018

Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.

Food & function

Price SJ,Pangloli P,Dia VP

Wed Dec 13 00:00:00 EST 2017

Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.

Food & function

Price SJ,Pangloli P,Dia VP

Wed Dec 13 00:00:00 EST 2017

A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.

Cell communication and signaling : CCS

Pang Y,Li C,Wang S,Ba W,Yu T,Pei G,Bi D,Liang H,Pan X,Zhu T,Gou M,Han Y,Li Q

Mon Oct 16 00:00:00 EDT 2017

A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.

Cell communication and signaling : CCS

Pang Y,Li C,Wang S,Ba W,Yu T,Pei G,Bi D,Liang H,Pan X,Zhu T,Gou M,Han Y,Li Q

Mon Oct 16 00:00:00 EDT 2017

Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.

Molecular vision

Yin Y,Chen F,Wang W,Wang H,Zhang X

Mon Jan 08 00:00:00 EST 2018

Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.

Molecular vision

Yin Y,Chen F,Wang W,Wang H,Zhang X

Mon Jan 08 00:00:00 EST 2018

The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.

Oncotarget

Chin LH,Hsu YJ,Hsu SC,Chen YH,Chang YL,Huang SM,Tsai CS,Lin CY

Tue Dec 26 00:00:00 EST 2017

The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.

Oncotarget

Chin LH,Hsu YJ,Hsu SC,Chen YH,Chang YL,Huang SM,Tsai CS,Lin CY

Tue Dec 26 00:00:00 EST 2017

The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

PLoS pathogens

Wang X,Shaw DK,Hammond HL,Sutterwala FS,Rayamajhi M,Shirey KA,Perkins DJ,Bonventre JV,Velayutham TS,Evans SM,Rodino KG,VieBrock L,Scanlon KM,Carbonetti NH,Carlyon JA,Miao EA,McBride JW,Kotsyfakis M,Pedra JH

Mon Aug 01 00:00:00 EDT 2016

The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

PLoS pathogens

Mon Aug 01 00:00:00 EDT 2016

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.

European journal of pharmacology

Zhou F,Zhang Y,Chen J,Hu X,Xu Y

Tue Nov 15 00:00:00 EST 2016

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.

European journal of pharmacology

Zhou F,Zhang Y,Chen J,Hu X,Xu Y

Tue Nov 15 00:00:00 EST 2016

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.

Applied and environmental microbiology

Wu Q,Liu MC,Yang J,Wang JF,Zhu YH

Mon Feb 15 00:00:00 EST 2016

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.

Applied and environmental microbiology

Wu Q,Liu MC,Yang J,Wang JF,Zhu YH

Mon Feb 15 00:00:00 EST 2016

Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.

Scientific reports

Fu X,Ju J,Lin Z,Xiao W,Li X,Zhuang B,Zhang T,Ma X,Li X,Ma C,Su W,Wang Y,Qin X,Liang S

Fri Jul 22 00:00:00 EDT 2016

Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.

Scientific reports

Fu X,Ju J,Lin Z,Xiao W,Li X,Zhuang B,Zhang T,Ma X,Li X,Ma C,Su W,Wang Y,Qin X,Liang S

Fri Jul 22 00:00:00 EDT 2016

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Scientific reports

Ding C,Zhao Y,Shi X,Zhang N,Zu G,Li Z,Zhou J,Gao D,Lv L,Tian X,Yao J

Mon Jun 27 00:00:00 EDT 2016

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Scientific reports

Ding C,Zhao Y,Shi X,Zhang N,Zu G,Li Z,Zhou J,Gao D,Lv L,Tian X,Yao J

Mon Jun 27 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

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Gene Aliases: CASP1; ICE; IL1BC; IL1BCE; P45

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UniProt ID: (Human) P29466, (Mouse) P29452

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Entrez Gene ID: (Human) 834, (Mouse) 12362, (Rat) 25166

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Function(s)

endopeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process peptidase activity cysteine-type peptidase activity hydrolase activity scaffold protein binding protease

Process(es)

response to hypoxia proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction regulation of autophagy protein processing response to lipopolysaccharide interleukin-1 beta production response to ATP regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response mitochondrial depolarization membrane hyperpolarization pyroptosis cellular response to mechanical stimulus cellular response to organic substance programmed necrotic cell death toxin transport microglial cell activation myoblast fusion memory response to bacterium response to organic cyclic compound response to drug positive regulation of apoptotic process positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of cytokine secretion midgut development response to toxic substance lung development execution phase of apoptosis

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Caspase 1/p20/p10 Polyclonal Antibody

Caspase 1/p20/p10 Antibody (22915-1-AP) in ICC/IF

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22915-1-AP

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Immunocytochemistry (ICC/IF)

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