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FIGURE: 1 / 1
Positive control: Brain tissue
Cellular location: Cytoplasmic.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-11; CASP-4; CASP13; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; MGC137679; Mih1; protease ICH-2; Protease ICH-3; Protease TX
Gene Aliases: CASP-11; CASP-4; Casp11; CASP4; Caspl; ICE(rel)II; ICEREL-II; ICH-2; ich-3; ICH2; Ich3; Mih1; Mih1/TX; TX
UniProt ID: (Human) P49662, (Mouse) P70343
Entrez Gene ID: (Human) 837, (Rat) 114555, (Mouse) 12363
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