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Invitrogen
Caspase 2 Recombinant Rabbit Monoclonal Antibody (23GB4375)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
Caspase 2 Antibody (MA5-53732) in ICC/IF
Immunocytochemistry analysis of Caspase 2 in HepG2 cells. Nuclei were stained blue with DAPI; Caspase 2 recombinant monoclonal antibody (Product # MA5-53732) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
Product Details
MA5-53732
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB4375
Immunogen
A synthesized peptide derived from human Caspase-2 (300-452AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Caspase 2 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP-2; caspase 2 apoptosis-related cysteine peptidase; Caspase-2; ICH-1 protease; ICH-1L; NEDD-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1; protein phosphatase 1, regulatory subunit 57
Gene Aliases: CASP-2; CASP2; ICH-1; ICH1; NEDD-2; NEDD2; PPP1R57
UniProt ID: (Human) P42575, (Mouse) P29594, (Rat) P55215
Entrez Gene ID: (Human) 835, (Mouse) 12366, (Rat) 64314
luteolysis
neural retina development
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
brain development
aging
intrinsic apoptotic signaling pathway in response to DNA damage
protein processing
ectopic germ cell programmed cell death
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
cellular response to mechanical stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
execution phase of apoptosis
positive regulation of apoptotic signaling pathway
proteolysis
programmed cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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