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Product Details
BS-3665R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Caspase-7, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-3; CASP-7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; CMH-1; Cysteine protease LICE2; ICE-LAP3; ICE-like apoptotic protease 3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
Gene Aliases: AI314680; CASP-7; CASP7; caspase-7; CMH-1; ICE-IAP3; ICE-LAP3; LICE2; mCASP-7; MCH3
UniProt ID: (Human) P55210, (Mouse) P97864
Entrez Gene ID: (Human) 840, (Rat) 64026, (Mouse) 12369
cysteine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process
peptidase activity
hydrolase activity
protease
proteolysis
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
execution phase of apoptosis
release of cytochrome c from mitochondria
heart development
aging
response to UV
protein processing
positive regulation of neuron apoptotic process
neuron apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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