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Invitrogen
Caspase 7 Recombinant Rabbit Monoclonal Antibody (23GB2305)
FIGURE: 1 / 3
Caspase 7 Antibody (MA5-52494) in ICC/IF
Immunocytochemistry analysis of Caspase 7 in C2C12 cells. Nuclei were stained blue with DAPI; Caspase 7 recombinant monoclonal antibody (Product # MA5-52494) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-52494
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB2305
Immunogen
A synthesized peptide derived from human Caspase-7 (260-303AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-3; CASP-7; Caspase-7; Cysteine protease LICE2; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
Gene Aliases: AI314680; Casp7; caspase-7; CMH-1; ICE-IAP3; Lice2; mCASP-7; Mch3
UniProt ID: (Mouse) P97864
Entrez Gene ID: (Rat) 64026, (Mouse) 12369
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activity involved in apoptotic process
protein binding
peptidase activity
hydrolase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
protease
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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