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Invitrogen
Caspase 7 (Cleaved Asp198) Polyclonal Antibody
Product Details
PA5-114688
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CASP7(Accession P55210), corresponding to amino acid residues P178-A207.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899324
Product Specific Information
Antibody detects endogenous levels of fragment of activated Caspase 7 resulting from cleavage adjacent to Asp198.
Target Information
Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-3; CASP-7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; CMH-1; Cysteine protease LICE2; ICE-LAP3; ICE-like apoptotic protease 3; Lice2 alpha/beta/gamma; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514
Gene Aliases: AI314680; CASP-7; CASP7; caspase-7; CMH-1; ICE-IAP3; ICE-LAP3; LICE2; mCASP-7; MCH3
UniProt ID: (Human) P55210, (Mouse) P97864
Entrez Gene ID: (Human) 840, (Mouse) 12369
cysteine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
aspartic-type endopeptidase activity
peptidase activity
hydrolase activity
cysteine-type endopeptidase activity involved in apoptotic process
protease
proteolysis
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
execution phase of apoptosis
heart development
response to UV
protein processing
neuron apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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