Proteintech

Catalase Polyclonal Antibody

Catalase Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

Catalase Antibody (21260-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using Catalase antibody (Product # 21260-1-AP) at dilution of 1:100 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Catalase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

21260-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 108 publications 108 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bat, Goat, Human, Mollusc, Mouse, Pig, Rat, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Catalase Fusion Protein Ag15383 (228-527 aa encoded by BC112219)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EAVYCKFHY KTDQGIKNLS VEDAARLSQE DPDYGIRDLF NAIATGKYPS WTFYIQVMTF NQAETFPFNP FDLTKVWPHK DYPLIPVGKL VLNRNPVNYF AEVEQIAFDP SNMPPGIEAS PDKMLQGRLF AYPDTHRHRL GPNYLHIPVN CPYRARVANY QRDGPMCMQD NQGGAPNYYP NSFGAPEQQP SALEHSIQYS GEVRRFNTAN DDNVTQVRAF YVNVLNEEQR KRLCENIAGH LKDAQIFIQK KAVKNFTEVH PDYGSHIQAL LDKYNAEKPK NAIHTFVQSG SHLAAREKAN L (228-527 aa encoded by BC112219)

Target Information

Catalase is a homotetrameric heme-containing enzyme present within the matrix of all peroxisomes. It carries out a dismutation reaction in which hydrogen peroxide is converted to water and oxygen. Human catalase has the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of human catalase is 61.3 kDa in molecular size. Catalase has been implicated as an important factor in inflammation, mutagenesis, prevention of apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Theriogenology

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Fri Mar 01 00:00:00 EST 2019

Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells.

Theriogenology

Guo YX,Zhang GM,Yao XL,Tong R,Cheng CY,Zhang TT,Wang ST,Yang H,Wang F

Fri Mar 01 00:00:00 EST 2019

Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.

Cells

Xu B,Lang LM,Li SZ,Guo JR,Wang JF,Wang D,Zhang LP,Yang HM,Lian S

Tue Jun 18 00:00:00 EDT 2019

Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.

Frontiers in physiology

Zhou D,Zhuang J,Wang Y,Zhao D,Zhao L,Zhu S,Pu J,Yin M,Zhang H,Wang Z,Hong J

Fri Apr 15 00:00:00 EDT 2022

Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.

Environmental toxicology and pharmacology

Yan X,Zhao F,Zhang S,Lei F,Wang W,Zheng Y

Wed May 01 00:00:00 EDT 2019

Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway.

Scientific reports

Rahman MA,Kodidela S,Sinha N,Haque S,Shukla PK,Rao R,Kumar S

Thu Apr 25 00:00:00 EDT 2019

Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion.

Oxidative medicine and cellular longevity

Wu Q,Lu K,Zhao Z,Wang B,Liu H,Zhang S,Liao J,Zeng Y,Dong Q,Zhao N,Han B,Du Y

Mon Jan 06 00:00:00 EST 2020

Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C.

Theriogenology

Shaoyong W,Li Q,Ren Z,Xiao J,Diao Z,Yang G,Pang W

Sun Dec 01 00:00:00 EST 2019

Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.

Brain sciences

Xu B,Lang LM,Lian S,Guo JR,Wang JF,Yang HM,Li SZ

Sat Oct 12 00:00:00 EDT 2019

The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages.

Biochemistry and biophysics reports

Gong Y,Rao PSS,Sinha N,Ranjit S,Cory TJ,Kumar S

Fri Mar 01 00:00:00 EST 2019

The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages.

Biochemistry and biophysics reports

Gong Y,Rao PSS,Sinha N,Ranjit S,Cory TJ,Kumar S

Fri Mar 01 00:00:00 EST 2019

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway.

BMC complementary and alternative medicine

Li C,Hu WL,Lu MX,Xiao GF

Thu Aug 29 00:00:00 EDT 2019

Exenatide Protects Against Cardiac Dysfunction by Attenuating Oxidative Stress in the Diabetic Mouse Heart.

Frontiers in endocrinology

Ding W,Chang WG,Guo XC,Liu Y,Xiao DD,Ding D,Wang JX,Zhang XJ

Tue Feb 25 00:00:00 EST 2020

l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.

Journal of the science of food and agriculture

Wang Z,Liang M,Li H,Cai L,He H,Wu Q,Yang L

Thu Aug 15 00:00:00 EDT 2019

Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.

Journal of the science of food and agriculture

Liang M,Li H,Wang Z,Cai L,Yang L

Tue Oct 01 00:00:00 EDT 2019

Correlation of Reactive Oxygen Species Levels with Resveratrol Sensitivities of Anaplastic Thyroid Cancer Cells.

Oxidative medicine and cellular longevity

Zheng X,Jia B,Tian XT,Song X,Wu ML,Kong QY,Li H,Liu J

Wed Dec 19 00:00:00 EST 2018

Correlation of Reactive Oxygen Species Levels with Resveratrol Sensitivities of Anaplastic Thyroid Cancer Cells.

Oxidative medicine and cellular longevity

Zheng X,Jia B,Tian XT,Song X,Wu ML,Kong QY,Li H,Liu J

Wed Dec 19 00:00:00 EST 2018

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 EDT 2018

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 EDT 2018

Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.

The Journal of international medical research

Niu X,Zhang J,Ling C,Bai M,Peng Y,Sun S,Li Y,Zhang Z

Tue May 01 00:00:00 EDT 2018

Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.

The Journal of international medical research

Niu X,Zhang J,Ling C,Bai M,Peng Y,Sun S,Li Y,Zhang Z

Tue May 01 00:00:00 EDT 2018

The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Hou Y,Shi Y,Han B,Liu X,Qiao X,Qi Y,Wang L

Thu Nov 01 00:00:00 EDT 2018

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.

Cell death & disease

Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X

Tue Dec 11 00:00:00 EST 2018

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.

Cell death & disease

Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X

Tue Dec 11 00:00:00 EST 2018

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhao F,Lei F,Yan X,Zhang S,Wang W,Zheng Y

Mon Sep 10 00:00:00 EDT 2018

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhao F,Lei F,Yan X,Zhang S,Wang W,Zheng Y

Mon Sep 10 00:00:00 EDT 2018

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

Oxidative medicine and cellular longevity

Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

Thu Apr 20 00:00:00 EDT 2017

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

Oxidative medicine and cellular longevity

Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

Thu Apr 20 00:00:00 EDT 2017

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases.

Journal of neurotrauma

Kong G,Huang Z,Ji W,Wang X,Liu J,Wu X,Huang Z,Li R,Zhu Q

Fri Sep 15 00:00:00 EDT 2017

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases.

Journal of neurotrauma

Kong G,Huang Z,Ji W,Wang X,Liu J,Wu X,Huang Z,Li R,Zhu Q

Fri Sep 15 00:00:00 EDT 2017

Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats.

Neuroscience

Wang X,Wu X,Liu Q,Kong G,Zhou J,Jiang J,Wu X,Huang Z,Su W,Zhu Q

Sat Dec 16 00:00:00 EST 2017

Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats.

Neuroscience

Wang X,Wu X,Liu Q,Kong G,Zhou J,Jiang J,Wu X,Huang Z,Su W,Zhu Q

Sat Dec 16 00:00:00 EST 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 EDT 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 EDT 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 EDT 2017

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 EDT 2017

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 EDT 2017

Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.

The journal of sexual medicine

Zhang Y,Yang J,Wang T,Wang SG,Liu JH,Yin CP,Ye ZQ

Tue Mar 01 00:00:00 EST 2016

Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.

The journal of sexual medicine

Zhang Y,Yang J,Wang T,Wang SG,Liu JH,Yin CP,Ye ZQ

Tue Mar 01 00:00:00 EST 2016

Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.

Biochemical and biophysical research communications

Jiao X,Li Y,Zhang T,Liu M,Chi Y

Fri Nov 18 00:00:00 EST 2016

Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.

Biochemical and biophysical research communications

Jiao X,Li Y,Zhang T,Liu M,Chi Y

Fri Nov 18 00:00:00 EST 2016

Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress.

Applied biochemistry and biotechnology

Liu Y,Zhai M,Guo F,Shi T,Liu J,Wang X,Zhang X,Jing D,Hai C

Fri Jul 01 00:00:00 EDT 2016

Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress.

Applied biochemistry and biotechnology

Liu Y,Zhai M,Guo F,Shi T,Liu J,Wang X,Zhang X,Jing D,Hai C

Fri Jul 01 00:00:00 EDT 2016

Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.

Anatomy & cell biology

Yoon SP,Kim J

Thu Sep 01 00:00:00 EDT 2016

Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.

Anatomy & cell biology

Yoon SP,Kim J

Thu Sep 01 00:00:00 EDT 2016

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Scientific reports

Li P,Zhang D,Shen L,Dong K,Wu M,Ou Z,Shi D

Wed Mar 09 00:00:00 EST 2016

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Scientific reports

Li P,Zhang D,Shen L,Dong K,Wu M,Ou Z,Shi D

Wed Mar 09 00:00:00 EST 2016

Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae).

PloS one

Yin Q,Zhu L,Liu D,Irwin DM,Zhang S,Pan YH

Wed Jul 06 00:00:00 EDT 2016

Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae).

PloS one

Yin Q,Zhu L,Liu D,Irwin DM,Zhang S,Pan YH

Wed Jul 06 00:00:00 EDT 2016

Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma.

Oncotarget

Li S,Mao Y,Zhou T,Luo C,Xie J,Qi W,Yang Z,Ma J,Gao G,Yang X

Tue May 31 00:00:00 EDT 2016

Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma.

Oncotarget

Li S,Mao Y,Zhou T,Luo C,Xie J,Qi W,Yang Z,Ma J,Gao G,Yang X

Tue May 31 00:00:00 EDT 2016

Cardioprotective effect of propofol against oxygen glucose deprivation and reperfusion injury in H9c2 cells.

Oxidative medicine and cellular longevity

Zhao D,Li Q,Huang Q,Li X,Yin M,Wang Z,Hong J

Thu Dec 03 00:00:00 EST 2015

Cardioprotective effect of propofol against oxygen glucose deprivation and reperfusion injury in H9c2 cells.

Oxidative medicine and cellular longevity

Zhao D,Li Q,Huang Q,Li X,Yin M,Wang Z,Hong J

Thu Dec 03 00:00:00 EST 2015

The role of catalase in the immune response to oxidative stress and pathogen challenge in the clam Meretrix meretrix.

Fish & shellfish immunology

Wang C,Yue X,Lu X,Liu B

Tue Jan 01 00:00:00 EST 2013

The role of catalase in the immune response to oxidative stress and pathogen challenge in the clam Meretrix meretrix.

Fish & shellfish immunology

Wang C,Yue X,Lu X,Liu B

Tue Jan 01 00:00:00 EST 2013

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Cell reports

Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D

Thu May 30 00:00:00 EDT 2013

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Cell reports

Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D

Thu May 30 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: Catalase; catalase 1; CTA1; HGNC:1516; MGC138422; MGC138424

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Gene Aliases: 2210418N07; Cas-1; Cas1; CAT; Cat01; Catl; Cs-1; CS1

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UniProt ID: (Human) P04040, (Rat) P04762, (Mouse) P24270

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Entrez Gene ID: (Human) 847, (Rat) 24248, (Mouse) 12359

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Function(s)

aminoacylase activity catalase activity receptor binding antioxidant activity oxidoreductase activity, acting on peroxide as acceptor enzyme binding heme binding protein homodimerization activity metal ion binding NADP binding peroxidase activity oxidoreductase activity peroxidase

Process(es)

response to reactive oxygen species osteoblast differentiation ureteric bud development response to hypoxia purine nucleotide catabolic process triglyceride metabolic process aging cholesterol metabolic process aerobic respiration response to light intensity UV protection response to ozone response to lead ion positive regulation of phosphatidylinositol 3-kinase signaling response to activity response to inactivity hemoglobin metabolic process negative regulation of NF-kappaB transcription factor activity response to estradiol response to insulin response to vitamin A response to vitamin E response to L-ascorbic acid response to drug response to hydrogen peroxide hydrogen peroxide catabolic process negative regulation of apoptotic process response to ethanol response to cadmium ion positive regulation of NF-kappaB transcription factor activity protein tetramerization protein homotetramerization positive regulation of cell division response to hyperoxia response to fatty acid cellular response to growth factor stimulus response to phenylpropanoid cellular oxidant detoxification kidney development response to oxidative stress response to radiation response to UV response to toxic substance oxidation-reduction process

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Catalase Polyclonal Antibody

Catalase Antibody (21260-1-AP) in ICC/IF

Product Details

21260-1-AP

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Immunocytochemistry (ICC/IF)

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Immunoprecipitation (IP)

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