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Invitrogen
Catalase Recombinant Superclonal Antibody (10HCLC)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 2
Catalase Antibody (711767) in ICC/IF
For immunofluorescence analysis,HepG2 cells were fixed and permeabilized for detection of endogenous Catalase using Anti-CatalaseRecombinant Rabbit Polyclonal Antibody (Product # 711767, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Catalase protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product... View More
Product Details
711767
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
10HCLC
Immunogen
Protein corresponding to human Catalase (aa1-aa527)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2716908
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Pig, Sheep
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
Catalase is a homotetrameric heme-containing enzyme present within the matrix of all peroxisomes. It carries out a dismutation reaction in which hydrogen peroxide is converted to water and oxygen. Human catalase has the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of human catalase is 61.3 kDa in molecular size. Catalase has been implicated as an important factor in inflammation, mutagenesis, prevention of apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Catalase; CTA1; HGNC:1516; MGC138422; MGC138424
Gene Aliases: CAT
UniProt ID: (Human) P04040
Entrez Gene ID: (Human) 847
response to reactive oxygen species
osteoblast differentiation
ureteric bud development
response to hypoxia
purine nucleotide catabolic process
triglyceride metabolic process
aging
cholesterol metabolic process
aerobic respiration
response to light intensity
UV protection
response to ozone
response to lead ion
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
response to inactivity
hemoglobin metabolic process
negative regulation of NF-kappaB transcription factor activity
response to estradiol
response to insulin
response to vitamin A
response to vitamin E
response to L-ascorbic acid
response to drug
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
response to ethanol
response to cadmium ion
positive regulation of NF-kappaB transcription factor activity
protein tetramerization
protein homotetramerization
positive regulation of cell division
response to hyperoxia
response to fatty acid
cellular response to growth factor stimulus
response to phenylpropanoid
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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