Proteintech

Catalase Monoclonal Antibody (1F8D7)

Catalase Antibody in Immunocytochemistry (ICC/IF)

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Catalase Antibody (66765-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using 66765-1-Ig (Catalase antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Mouse IgG (H+L).

Catalase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

66765-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500

Immunocytochemistry (ICC/IF)

1:50

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1F8D7

Immunogen

Catalase Fusion Protein Ag16916 (228-527 aa encoded by BC112219)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EAVYCKFHY KTDQGIKNLS VEDAARLSQE DPDYGIRDLF NAIATGKYPS WTFYIQVMTF NQAETFPFNP FDLTKVWPHK DYPLIPVGKL VLNRNPVNYF AEVEQIAFDP SNMPPGIEAS PDKMLQGRLF AYPDTHRHRL GPNYLHIPVN CPYRARVANY QRDGPMCMQD NQGGAPNYYP NSFGAPEQQP SALEHSIQYS GEVRRFNTAN DDNVTQVRAF YVNVLNEEQR KRLCENIAGH LKDAQIFIQK KAVKNFTEVH PDYGSHIQAL LDKYNAEKPK NAIHTFVQSG SHLAAREKAN L (228-527 aa encoded by BC112219)

Target Information

Catalase is a homotetrameric heme-containing enzyme present within the matrix of all peroxisomes. It carries out a dismutation reaction in which hydrogen peroxide is converted to water and oxygen. Human catalase has the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of human catalase is 61.3 kDa in molecular size. Catalase has been implicated as an important factor in inflammation, mutagenesis, prevention of apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Nanodrug rescues liver fibrosis via synergistic therapy with H₂O₂ depletion and Saikosaponin b1 sustained release.

Communications biology

Dong H,Han X,Hao M,Yang Q,Lyu Q,Tang D,Shen Z,Wang K,Kuang H,Cao G,Peng M,Shao M

Thu Feb 16 00:00:00 EST 2023

Nanodrug rescues liver fibrosis via synergistic therapy with H₂O₂ depletion and Saikosaponin b1 sustained release.

Communications biology

Dong H,Han X,Hao M,Yang Q,Lyu Q,Tang D,Shen Z,Wang K,Kuang H,Cao G,Peng M,Shao M

Thu Feb 16 00:00:00 EST 2023

Nanodrug rescues liver fibrosis via synergistic therapy with H₂O₂ depletion and Saikosaponin b1 sustained release.

Communications biology

Dong H,Han X,Hao M,Yang Q,Lyu Q,Tang D,Shen Z,Wang K,Kuang H,Cao G,Peng M,Shao M

Thu Feb 16 00:00:00 EST 2023

Nanodrug rescues liver fibrosis via synergistic therapy with H₂O₂ depletion and Saikosaponin b1 sustained release.

Communications biology

Dong H,Han X,Hao M,Yang Q,Lyu Q,Tang D,Shen Z,Wang K,Kuang H,Cao G,Peng M,Shao M

Thu Feb 16 00:00:00 EST 2023

Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.

Journal of ethnopharmacology

Liu J,Yang Y,He Y,Feng C,Ou H,Yang J,Chen Y,You F,Shao B,Bao J,Guan X,Chen F,Zhao P

Sat Mar 25 00:00:00 EDT 2023

Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease.

Translational research : the journal of laboratory and clinical medicine

Fletcher E,Miserlis D,Sorokolet K,Wilburn D,Bradley C,Papoutsi E,Wilkinson T,Ring A,Ferrer L,Haynatzki G,Smith RS,Bohannon WT,Koutakis P

Sun Oct 01 00:00:00 EDT 2023

Maslinic Acid Supplementation during the In Vitro Culture Period Ameliorates Early Embryonic Development of Porcine Embryos by Regulating Oxidative Stress.

Animals : an open access journal from MDPI

Yang TT,Qi JJ,Sun BX,Qu HX,Wei HK,Sun H,Jiang H,Zhang JB,Liang S

Mon Mar 13 00:00:00 EDT 2023

Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.

The American journal of pathology

Li Q,Wang H,Liu L,Weng Y,Xu S,Li L,Wang Z

Wed Feb 01 00:00:00 EST 2023

Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.

Oxidative medicine and cellular longevity

Liu H,Xie J,Fan L,Xia Y,Peng X,Zhou J,Ni X

Fri Apr 15 00:00:00 EDT 2022

Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.

Microbiome

Wang L,Liu Q,Chen Y,Zheng X,Wang C,Qi Y,Dong Y,Xiao Y,Chen C,Chen T,Huang Q,Zhai Z,Long C,Yang H,Li J,Wang L,Zhang G,Liao P,Liu YX,Huang P,Huang J,Wang Q,Chu H,Yin J,Yin Y

Wed Jun 01 00:00:00 EDT 2022

Melatonin ameliorates cypermethrin-induced impairments by regulating oxidative stress, DNA damage and apoptosis in porcine Sertoli cells.

Theriogenology

Li J,Sun BX,Wang DL,Liu Y,Qi JJ,Nie XW,Bai CY,Zhang JB,Liang S

Tue Jun 01 00:00:00 EDT 2021

High-Intensity Interval Training and Moderate-Intensity Continuous Training Attenuate Oxidative Damage and Promote Myokine Response in the Skeletal Muscle of ApoE KO Mice on High-Fat Diet.

Antioxidants (Basel, Switzerland)

Wang L,Lavier J,Hua W,Wang Y,Gong L,Wei H,Wang J,Pellegrin M,Millet GP,Zhang Y

Tue Jun 22 00:00:00 EDT 2021

PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.

European journal of pharmacology

Wang M,Li J,Ding Y,Cai S,Li Z,Liu P

Sun Sep 05 00:00:00 EDT 2021

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.

Biomaterials

Wang T,Jian Z,Baskys A,Yang J,Li J,Guo H,Hei Y,Xian P,He Z,Li Z,Li N,Long Q

Thu Oct 01 00:00:00 EDT 2020

Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway.

Oxidative medicine and cellular longevity

Feng TY,Li Q,Ren F,Xi HM,Lv DL,Li Y,Hu JH

Fri Sep 03 00:00:00 EDT 2021

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Haematologica

Maio N,Kim KS,Holmes-Hampton G,Singh A,Rouault TA

Sun Sep 01 00:00:00 EDT 2019

Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.

Scientific reports

Han J,Guo D,Sun XY,Wang JM,Ouyang JM,Gui BS

Mon Jul 08 00:00:00 EDT 2019

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P₂ and extended synaptotagmins.

Science China. Life sciences

Xiao J,Luo J,Hu A,Xiao T,Li M,Kong Z,Jiang L,Zhou Z,Liao Y,Xie C,Chu B,Miao H,Li B,Shi X,Song BL

Sun Sep 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: Catalase; catalase 1; CTA1; HGNC:1516; MGC138422; MGC138424

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Gene Aliases: 2210418N07; Cas-1; Cas1; CAT; Cat01; Catl; Cs-1; CS1

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UniProt ID: (Human) P04040, (Pig) O62839, (Rat) P04762, (Mouse) P24270

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Entrez Gene ID: (Human) 847, (Pig) 397568, (Rat) 24248, (Mouse) 12359

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Function(s)

aminoacylase activity catalase activity receptor binding antioxidant activity oxidoreductase activity, acting on peroxide as acceptor enzyme binding heme binding protein homodimerization activity metal ion binding NADP binding peroxidase activity oxidoreductase activity peroxidase

Process(es)

response to reactive oxygen species osteoblast differentiation ureteric bud development response to hypoxia purine nucleotide catabolic process triglyceride metabolic process aging cholesterol metabolic process aerobic respiration response to light intensity UV protection response to ozone response to lead ion positive regulation of phosphatidylinositol 3-kinase signaling response to activity response to inactivity hemoglobin metabolic process negative regulation of NF-kappaB transcription factor activity response to estradiol response to insulin response to vitamin A response to vitamin E response to L-ascorbic acid response to drug response to hydrogen peroxide hydrogen peroxide catabolic process negative regulation of apoptotic process response to ethanol response to cadmium ion positive regulation of NF-kappaB transcription factor activity protein tetramerization protein homotetramerization positive regulation of cell division response to hyperoxia response to fatty acid cellular response to growth factor stimulus response to phenylpropanoid cellular oxidant detoxification oxidation-reduction process kidney development response to oxidative stress response to radiation response to UV response to toxic substance

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Catalase Monoclonal Antibody (1F8D7)

Catalase Antibody (66765-1-IG) in ICC/IF

Product Details

66765-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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