Proteintech

Cathepsin D Polyclonal Antibody

Cathepsin D Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

Cathepsin D Antibody (21327-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CTSD antibody 21327-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Cathepsin D Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cathepsin D Antibody in Western Blot (WB)

Product Image Gallery

Product Details

21327-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 76 publications 76 publications

Immunohistochemistry (IHC)

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

View 9 publications 9 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cathepsin D Fusion Protein Ag15254 (59-412 aa encoded by BC016320)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to CTSD.

Immunogen sequence: VPAVTEGPI PEVLKNYMDA QYYGEIGIGT PPQCFTVVFD TGSSNLWVPS IHCKLLDIAC WIHHKYNSDK SSTYVKNGTS FDIHYGSGSL SGYLSQDTVS VPCQSASSAS ALGGVKVERQ VFGEATKQPG ITFIAAKFDG ILGMAYPRIS VNNVLPVFDN LMQQKLVDQN IFSFYLSRDP DAQPGGELML GGTDSKYYKG SLSYLNVTRK AYWQVHLDQV EVASGLTLCK EGCEAIVDTG TSLMVGPVDE VRELQKAIGA VPLIQGEYMI PCEKVSTLPA ITLKLGGKGY KLSPEDYTLK VSQAGKTLCL SGFMGMDIPP PSGPLWILGD VFIGRYYTVF DRDNNRVGFA EAARL (59-412 aa encoded by B C016320)

Target Information

Cathepsin D has been reported to be involved in malignant tumor progression and with prognosis of various human cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.

International journal of oncology

Hao Y,Song T,Wang M,Li T,Zhao C,Li T,Hou Y,He H

Wed Mar 01 00:00:00 EST 2023

Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.

International immunopharmacology

Ye H,Li F,Shen Y,Wu X,Zhao L,Zhang H,Yang J,Shui X

Mon May 01 00:00:00 EDT 2023

Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.

International immunopharmacology

Ye H,Li F,Shen Y,Wu X,Zhao L,Zhang H,Yang J,Shui X

Mon May 01 00:00:00 EDT 2023

Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.

Autophagy

Fang Z,Xu Y,Liu G,Shao Q,Niu X,Tai W,Shen T,Fan M,Chen M,Lei L,Gao W,Song Y,Wang Z,Du X,Li X

Tue Aug 01 00:00:00 EDT 2023

Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health.

Nature communications

Daly JL,Danson CM,Lewis PA,Zhao L,Riccardo S,Di Filippo L,Cacchiarelli D,Lee D,Cross SJ,Heesom KJ,Xiong WC,Ballabio A,Edgar JR,Cullen PJ

Mon May 29 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.

Cancer science

Zhang Z,Shi Y,Zhu Z,Fu J,Liu D,Liu X,Dang J,Tao H,Fan H

Sat Apr 01 00:00:00 EDT 2023

Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.

Cancer science

Zhang Z,Shi Y,Zhu Z,Fu J,Liu D,Liu X,Dang J,Tao H,Fan H

Sat Apr 01 00:00:00 EDT 2023

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.

Journal of neuroinflammation

Zhang H,Chen Y,Li F,Wu C,Cai W,Ye H,Su H,He M,Yang L,Wang X,Zhou K,Ni W

Sat Jan 07 00:00:00 EST 2023

Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.

Research (Washington, D.C.)

Zheng B,He Y,Yin S,Zhu X,Zhao Q,Yang H,Wang Z,Zhu R,Cheng L

Thu May 25 00:00:00 EDT 2023

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons.

bioRxiv : the preprint server for biology

Hasan S,Fernandopulle MS,Humble SW,Frankenfield AM,Li H,Prestil R,Johnson KR,Ryan BJ,Wade-Martins R,Ward ME,Hao L

Fri Feb 24 00:00:00 EST 2023

Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.

Methods in molecular biology (Clifton, N.J.)

Arab M,Nayak SC,Vitali T,Lowe M

Thu Dec 15 00:00:00 EST 2022

A novel selective estrogen receptor degrader induces cell cycle arrest in breast cancer via ERα degradation and the autophagy-lysosome pathway.

Bioorganic & medicinal chemistry

Zhou J,Shen R,Liu J,Deng X,Xin L,Zhou HB,Huang J

Wed Mar 15 00:00:00 EDT 2023

Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.

International immunopharmacology

Xue K,Zhang G,Zhou Y,Wang K,Yao Z,Chen J,Zhang Y,Li Z,Li Z,Zheng Z,Feng Y,Mao C,Lin C,Xia W

Thu Jun 01 00:00:00 EDT 2023

Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke.

Experimental neurology

Zhao Y,Hong Z,Lin Y,Shen W,Yang Y,Zuo Z,Hu X

Thu Jun 01 00:00:00 EDT 2023

Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke.

Experimental neurology

Zhao Y,Hong Z,Lin Y,Shen W,Yang Y,Zuo Z,Hu X

Thu Jun 01 00:00:00 EDT 2023

Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.

Phytotherapy research : PTR

Zhang H,Wu C,Yu DD,Su H,Chen Y,Ni W

Wed Feb 01 00:00:00 EST 2023

Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.

Cell chemical biology

Liu Y,Sun Y,Xu Y,Dong T,Qian L,Zheng H,Gao Y,Chu Z,Fu X,Zhang H,Xie F,Zhang C,Tang Y,Lou H

Thu Feb 16 00:00:00 EST 2023

Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress.

Journal of hazardous materials

Gong ZG,Zhao Y,Wang ZY,Fan RF,Liu ZP,Wang L

Sat Feb 05 00:00:00 EST 2022

Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.

British journal of pharmacology

Lou J,Zhang H,Qi J,Xu Y,Wang X,Jiang J,Hu X,Ni L,Cai Y,Wang X,Gao W,Xiao J,Zhou K

Sat Jan 01 00:00:00 EST 2022

Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues.

Journal of dairy science

Yu H,Fan M,Chen X,Jiang X,Loor JJ,Aboragah A,Zhang C,Bai H,Fang Z,Shen T,Wang Z,Song Y,Li X,Liu G,Li X,Du X

Mon Aug 01 00:00:00 EDT 2022

Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca²⁺-PPP3/calcineurin-TFEB axis.

Autophagy

Zummo FP,Krishnanda SI,Georgiou M,O'Harte FP,Parthsarathy V,Cullen KS,Honkanen-Scott M,Shaw JA,Lovat PE,Arden C

Fri Apr 01 00:00:00 EDT 2022

Paeonol protects renal tubular cells against cadmium-induced cytotoxicity via alleviating oxidative stress, inhibiting inflammatory responses and restoring autophagy.

Journal of inorganic biochemistry

Liu W,Gong Z,Zhang K,Dong W,Zou H,Song R,Bian J,Zhu J,Liu G,Liu Z

Sun May 01 00:00:00 EDT 2022

Wolframin is a novel regulator of tau pathology and neurodegeneration.

Acta neuropathologica

Chen S,Acosta D,Li L,Liang J,Chang Y,Wang C,Fitzgerald J,Morrison C,Goulbourne CN,Nakano Y,Villegas NCH,Venkataraman L,Brown C,Serrano GE,Bell E,Wemlinger T,Wu M,Kokiko-Cochran ON,Popovich P,Flowers XE,Honig LS,Vonsattel JP,Scharre DW,Beach TG,Ma Q,Kuret J,Kõks S,Urano F,Duff KE,Fu H

Sun May 01 00:00:00 EDT 2022

Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.

Molecular cell

Zhang Z,Chen C,Yang F,Zeng YX,Sun P,Liu P,Li X

Thu Aug 04 00:00:00 EDT 2022

Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.

Ecotoxicology and environmental safety

Han X,Tang Y,Zhang Y,Zhang J,Hu Z,Xu W,Xu S,Niu Q

Sun May 01 00:00:00 EDT 2022

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway.

Acta pharmaceutica Sinica. B

Du X,Di Malta C,Fang Z,Shen T,Niu X,Chen M,Jin B,Yu H,Lei L,Gao W,Song Y,Wang Z,Xu C,Cao Z,Liu G,Li X

Wed Jun 01 00:00:00 EDT 2022

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.

Nature communications

Zhang W,Yang X,Li Y,Yu L,Zhang B,Zhang J,Cho WJ,Venkatarangan V,Chen L,Burugula BB,Bui S,Wang Y,Duan C,Kitzman JO,Li M

Mon Sep 12 00:00:00 EDT 2022

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

Cell reports

Luo Q,Liu Q,Cheng H,Wang J,Zhao T,Zhang J,Mu C,Meng Y,Chen L,Zhou C,Lei H,Yang J,Chen G,Li Y,Pan L,Chen Q,Zhu Y

Tue Aug 16 00:00:00 EDT 2022

Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis.

Journal of dairy science

Fang Z,Li X,Wang S,Jiang Q,Loor JJ,Jiang X,Ju L,Yu H,Shen T,Chen M,Song Y,Wang Z,Du X,Liu G

Sun May 01 00:00:00 EDT 2022

Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.

Oxidative medicine and cellular longevity

Jiang RH,Dong CJ,Chen ZL,Cheng S,Yang JX,Gao WY

Mon May 30 00:00:00 EDT 2022

Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.

Oxidative medicine and cellular longevity

Jiang RH,Dong CJ,Chen ZL,Cheng S,Yang JX,Gao WY

Mon May 30 00:00:00 EDT 2022

Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.

International journal of biological sciences

Li Z,Wang T,Xin C,Song Y,Kong J,Xu J,Liu Q,Teng Y,Hou N,Cheng X,Yang G,Liu W,Zhou B,Zhang Y,Yang X,Wang J

Fri Dec 23 00:00:00 EST 2022

SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking.

bioRxiv : the preprint server for biology

Zhang J,Kennedy A,Xing L,Bui S,Reid W,Joppich J,Ahat E,Rose M,Tang Q,Tai AW,Wang Y

Wed Mar 09 00:00:00 EST 2022

SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking.

bioRxiv : the preprint server for biology

Zhang J,Kennedy A,Xing L,Bui S,Reid W,Joppich J,Ahat E,Rose M,Tang Q,Tai AW,Wang Y

Wed Mar 09 00:00:00 EST 2022

Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.

Nature communications

Singh J,Elhabashy H,Muthukottiappan P,Stepath M,Eisenacher M,Kohlbacher O,Gieselmann V,Winter D

Thu Oct 20 00:00:00 EDT 2022

Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.

Autophagy

Zhou Z,Wang H,Zhang X,Song M,Yao S,Jiang P,Liu D,Wang Z,Lv H,Li R,Hong Y,Dai J,Hu Y,Zhao G

Sat Oct 01 00:00:00 EDT 2022

Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.

Autophagy

Zhou Z,Wang H,Zhang X,Song M,Yao S,Jiang P,Liu D,Wang Z,Lv H,Li R,Hong Y,Dai J,Hu Y,Zhao G

Sat Oct 01 00:00:00 EDT 2022

Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.

Autophagy

Zhou Z,Wang H,Zhang X,Song M,Yao S,Jiang P,Liu D,Wang Z,Lv H,Li R,Hong Y,Dai J,Hu Y,Zhao G

Sat Oct 01 00:00:00 EDT 2022

Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.

Autophagy

Zhou Z,Wang H,Zhang X,Song M,Yao S,Jiang P,Liu D,Wang Z,Lv H,Li R,Hong Y,Dai J,Hu Y,Zhao G

Sat Oct 01 00:00:00 EDT 2022

Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.

Nutrients

Yang Y,Li X,Liu Z,Ruan X,Wang H,Zhang Q,Cao L,Song L,Chen Y,Sun Y

Sun Nov 20 00:00:00 EST 2022

GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.

Brain research

Zhang Y,Wu Z,Huang Z,Liu Y,Chen X,Zhao X,He H,Deng Y

Tue Mar 01 00:00:00 EST 2022

Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.

Cell death and differentiation

Chen X,Guan Y,Zhang Y,Jia Y,Li W,Guo C,Li Y,Wang X,Shi Y,Wang Q,Zhu F,Li Y,Zhang L

Thu Apr 01 00:00:00 EDT 2021

GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.

Oxidative medicine and cellular longevity

Xu Y,Hu X,Li F,Zhang H,Lou J,Wang X,Wang H,Yin L,Ni W,Kong J,Wang X,Li Y,Zhou K,Xu H

Mon Feb 07 00:00:00 EST 2022

1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Fan Y,Lu J,Liu J,Zhang R,Yu Z,Guan S

Mon Nov 01 00:00:00 EDT 2021

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.

Cell reports

Wu Y,Shao W,Todd TW,Tong J,Yue M,Koga S,Castanedes-Casey M,Librero AL,Lee CW,Mackenzie IR,Dickson DW,Zhang YJ,Petrucelli L,Prudencio M

Tue Aug 24 00:00:00 EDT 2021

Curcumin promotes the survival of ischemic random skin flaps via autophagy.

American journal of translational research

Tu Z,Jiang X,Li Y,Yang S,Lin D,Shi Y,Mao C,Zhang X,Lin C

Tue Apr 13 00:00:00 EDT 2021

Curcumin promotes the survival of ischemic random skin flaps via autophagy.

American journal of translational research

Tu Z,Jiang X,Li Y,Yang S,Lin D,Shi Y,Mao C,Zhang X,Lin C

Tue Apr 13 00:00:00 EDT 2021

Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.

Journal of cellular physiology

Li J,Chen H,Lou J,Bao G,Wu C,Lou Z,Wang X,Ding J,Li Z,Xiao J,Xu H,Gao W,Zhou K

Sat May 01 00:00:00 EDT 2021

Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy.

Microorganisms

Yuan L,Chu B,Chen S,Li Y,Liu N,Zhu Y,Zhou D

Tue Nov 16 00:00:00 EST 2021

DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.

Cell death & disease

Cao Y,Li R,Shen M,Li C,Zou Y,Jiang Q,Liu S,Lu C,Li H,Liu H,Cai Y

Tue Apr 20 00:00:00 EDT 2021

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.

Frontiers in pharmacology

Zhou F,Zhang X,Jiang L,Li S,Chen Y,Wu J

Tue May 18 00:00:00 EDT 2021

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.

Frontiers in pharmacology

Zhou F,Zhang X,Jiang L,Li S,Chen Y,Wu J

Tue May 18 00:00:00 EDT 2021

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.

Oxidative medicine and cellular longevity

Zhu X,Hu X,Lou J,Li J,Xu Y,Yu G,Wu C,Ding J,Gao W,Xiao J,Zhou K,Jia C

Fri May 28 00:00:00 EDT 2021

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.

Oxidative medicine and cellular longevity

Zhu X,Hu X,Lou J,Li J,Xu Y,Yu G,Wu C,Ding J,Gao W,Xiao J,Zhou K,Jia C

Fri May 28 00:00:00 EDT 2021

TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.

Cell death & disease

Hu J,Ding X,Tian S,Chu Y,Liu Z,Li Y,Li X,Wang G,Wang L,Wang Z

Mon Apr 12 00:00:00 EDT 2021

Prenatal-onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation.

Birth defects research

Chartier S,Boutaud L,Le Guillou E,Alby C,Billon C,Millischer AE,Caillaud C,Galmiche L,Mechler C,Sonigo P,Boddaert N,Lyonnet S,Rondeau S,Bole-Feysot C,Masson C,Ville Y,Roth P,Desguerre I,Encha-Razavi F,Attie-Bitach T

Mon Nov 01 00:00:00 EDT 2021

Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.

Acta pharmacologica Sinica

Dong WL,Zhong JH,Chen YQ,Xie JF,Qin YY,Xu JP,Cai NB,Li MF,Liu L,Wang HT

Wed Dec 01 00:00:00 EST 2021

Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.

Autophagy

Hossain MI,Marcus JM,Lee JH,Garcia PL,Singh V,Shacka JJ,Zhang J,Gropen TI,Falany CN,Andrabi SA

Tue Jun 01 00:00:00 EDT 2021

Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.

Autophagy

Hossain MI,Marcus JM,Lee JH,Garcia PL,Singh V,Shacka JJ,Zhang J,Gropen TI,Falany CN,Andrabi SA

Tue Jun 01 00:00:00 EDT 2021

Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.

Autophagy

Hossain MI,Marcus JM,Lee JH,Garcia PL,Singh V,Shacka JJ,Zhang J,Gropen TI,Falany CN,Andrabi SA

Tue Jun 01 00:00:00 EDT 2021

Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.

Autophagy

Hossain MI,Marcus JM,Lee JH,Garcia PL,Singh V,Shacka JJ,Zhang J,Gropen TI,Falany CN,Andrabi SA

Tue Jun 01 00:00:00 EDT 2021

Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.

Autophagy

Zhang X,Wei M,Fan J,Yan W,Zha X,Song H,Wan R,Yin Y,Wang W

Tue Jun 01 00:00:00 EDT 2021

Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.

International journal of biological sciences

Wu C,Chen H,Zhuang R,Zhang H,Wang Y,Hu X,Xu Y,Li J,Li Y,Wang X,Xu H,Ni W,Zhou K

Fri Jan 21 00:00:00 EST 2022

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Archives of pharmacal research

Wang J,Su Q,Wu Q,Chen K,Ullah A,Ghauri MA,Zhang Y

Mon Nov 01 00:00:00 EDT 2021

Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.

Frontiers in cardiovascular medicine

Yu YW,Que JQ,Liu S,Huang KY,Qian L,Weng YB,Rong FN,Wang L,Zhou YY,Xue YJ,Ji KT

Fri Jan 28 00:00:00 EST 2022

Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.

Frontiers in cellular neuroscience

Xie D,Zhao T,Zhang X,Kui L,Wang Q,Wu Y,Zheng T,Ma P,Zhang Y,Molteni H,Geng R,Yang Y,Li B,Zheng QY

Wed Feb 16 00:00:00 EST 2022

Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting.

Journal of cell science

Evans AJ,Daly JL,Anuar ANK,Simonetti B,Cullen PJ

Mon Aug 03 00:00:00 EDT 2020

Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.

Artificial cells, nanomedicine, and biotechnology

Chen M,Ding Y,Ke Y,Zeng Y,Liu N,Zhong Y,Hua X,Li Z,Xiong Y,Wu C,Yu H

Tue Dec 01 00:00:00 EST 2020

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.

Theranostics

Zhou K,Zheng Z,Li Y,Han W,Zhang J,Mao Y,Chen H,Zhang W,Liu M,Xie L,Zhang H,Xu H,Xiao J

Fri May 28 00:00:00 EDT 2021

Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.

Ecotoxicology and environmental safety

Guan S,Tao S,Huang Y,Jin Y,Hu Y,Lu J

Tue Dec 01 00:00:00 EST 2020

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.

Journal of experimental & clinical cancer research : CR

Yang Y,Wang Q,Song D,Zen R,Zhang L,Wang Y,Yang H,Zhang D,Jia J,Zhang J,Wang J

Tue Sep 22 00:00:00 EDT 2020

Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.

Frontiers in pharmacology

Li B,Chen Z,Luo X,Zhang C,Chen H,Wang S,Zhao M,Ma H,Liu J,Cheng M,Yang Y,Yan H

Tue Feb 16 00:00:00 EST 2021

Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.

Frontiers in pharmacology

Wu C,Xu H,Li J,Hu X,Wang X,Huang Y,Li Y,Sheng S,Wang Y,Xu H,Ni W,Zhou K

Sat Apr 16 00:00:00 EDT 2022

Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.

Frontiers in pharmacology

Chen Z,Zhang C,Ma H,Huang Z,Li J,Lou J,Li B,Tu Q,Gao W

Mon Sep 28 00:00:00 EDT 2020

Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.

Frontiers in pharmacology

Chen Z,Zhang C,Ma H,Huang Z,Li J,Lou J,Li B,Tu Q,Gao W

Mon Sep 28 00:00:00 EDT 2020

An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.

Molecular neurobiology

Lan Y,Li Z,Wang Z,Wang X,Wang G,Zhang J,Hu S,Zhao K,Xu B,Gao F,He W

Tue Dec 01 00:00:00 EST 2020

Autophagic blockage by bismuth sulfide nanoparticles inhibits migration and invasion of HepG2 cells.

Nanotechnology

Hao BM,Liu YN,Zhang CY,Li GQ,Wang WN,Xu WD,Zha ZB,Wang F,Li C,Miao ZH,Yang XX,Chen YL,Qian HS,Zhou W

Fri Nov 13 00:00:00 EST 2020

Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.

Frontiers in immunology

Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

Mon Mar 29 00:00:00 EDT 2021

Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.

Biochimica et biophysica acta. General subjects

Cui X,Feng R,Wang J,Du C,Pi X,Chen D,Li J,Li H,Zhang J,Zhang J,Mu H,Zhang F,Liu M,Hu Y

Sun Mar 01 00:00:00 EST 2020

Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.

Frontiers in pharmacology

Wang W,Huang L,Thomas ER,Hu Y,Zeng F,Li X

Thu Oct 01 00:00:00 EDT 2020

Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.

American journal of translational research

Zhang C,Shao Z,Chen Z,Lin C,Hu S,Lou Z,Li J,Zheng X,Lin N,Gao W

Mon Sep 28 00:00:00 EDT 2020

Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.

American journal of translational research

Zhang C,Shao Z,Chen Z,Lin C,Hu S,Lou Z,Li J,Zheng X,Lin N,Gao W

Mon Sep 28 00:00:00 EDT 2020

FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.

Cell death & disease

Zhou K,Chen H,Lin J,Xu H,Wu H,Bao G,Li J,Deng X,Shui X,Gao W,Ding J,Xiao J,Xu H

Mon Nov 18 00:00:00 EST 2019

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.

Cell proliferation

Sheng J,Shen L,Sun L,Zhang X,Cui R,Wang L

Wed May 01 00:00:00 EDT 2019

ERβ promotes Aβ degradation via the modulation of autophagy.

Cell death & disease

Wei Y,Zhou J,Wu J,Huang J

Mon Jul 22 00:00:00 EDT 2019

Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.

American journal of translational research

Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

Tue Sep 29 00:00:00 EDT 2020

Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.

American journal of translational research

Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

Tue Sep 29 00:00:00 EDT 2020

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.

Frontiers in pharmacology

Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

Thu Oct 01 00:00:00 EDT 2020

Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.

International journal of biological sciences

Wu H,Ding J,Li S,Lin J,Jiang R,Lin C,Dai L,Xie C,Lin D,Xu H,Gao W,Zhou K

Mon Jan 13 00:00:00 EST 2020

Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.

International journal of biological sciences

Wu H,Ding J,Li S,Lin J,Jiang R,Lin C,Dai L,Xie C,Lin D,Xu H,Gao W,Zhou K

Mon Jan 13 00:00:00 EST 2020

27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells.

Frontiers in molecular neuroscience

Chen S,Zhou C,Yu H,Tao L,An Y,Zhang X,Wang Y,Wang Y,Xiao R

Thu Oct 01 00:00:00 EDT 2020

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

Frontiers in pharmacology

Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

Sat Nov 04 00:00:00 EDT 2023

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

Frontiers in pharmacology

Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

Sat Nov 04 00:00:00 EDT 2023

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Proceedings of the National Academy of Sciences of the United States of America

Jinn S,Drolet RE,Cramer PE,Wong AH,Toolan DM,Gretzula CA,Voleti B,Vassileva G,Disa J,Tadin-Strapps M,Stone DJ

Tue Feb 28 00:00:00 EST 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Proceedings of the National Academy of Sciences of the United States of America

Jinn S,Drolet RE,Cramer PE,Wong AH,Toolan DM,Gretzula CA,Voleti B,Vassileva G,Disa J,Tadin-Strapps M,Stone DJ

Tue Feb 28 00:00:00 EST 2017

Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.

Nutrients

Xie X,Yi W,Zhang P,Wu N,Yan Q,Yang H,Tian C,Xiang S,Du M,Getachew Assefa E,Zuo X,Ying C

Sun May 14 00:00:00 EDT 2017

Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.

Nutrients

Xie X,Yi W,Zhang P,Wu N,Yan Q,Yang H,Tian C,Xiang S,Du M,Getachew Assefa E,Zuo X,Ying C

Sun May 14 00:00:00 EDT 2017

Epigallocatechin-3-gallate inhibits H₂O₂-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.

Scientific reports

Yan X,Li Y,Yu H,Wang W,Wu C,Yang Y,Hu Y,Shi X,Li J

Thu Aug 10 00:00:00 EDT 2017

Epigallocatechin-3-gallate inhibits H₂O₂-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.

Scientific reports

Yan X,Li Y,Yu H,Wang W,Wu C,Yang Y,Hu Y,Shi X,Li J

Thu Aug 10 00:00:00 EDT 2017

NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.

Cell death & disease

Wang H,Li W,Xu J,Zhang T,Zuo D,Zhou Z,Lin B,Wang G,Wang Z,Sun W,Sun M,Chang S,Cai Z,Hua Y

Thu Sep 14 00:00:00 EDT 2017

NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.

Cell death & disease

Wang H,Li W,Xu J,Zhang T,Zuo D,Zhou Z,Lin B,Wang G,Wang Z,Sun W,Sun M,Chang S,Cai Z,Hua Y

Thu Sep 14 00:00:00 EDT 2017

Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.

British journal of pharmacology

Mei L,Chen Y,Wang Z,Wang J,Wan J,Yu C,Liu X,Li W

Fri May 01 00:00:00 EDT 2015

Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.

British journal of pharmacology

Mei L,Chen Y,Wang Z,Wang J,Wan J,Yu C,Liu X,Li W

Fri May 01 00:00:00 EDT 2015

Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells.

Toxins

Wang Y,Liu Y,Liu X,Jiang L,Yang G,Sun X,Geng C,Li Q,Yao X,Chen M

Thu Aug 06 00:00:00 EDT 2015

Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells.

Toxins

Wang Y,Liu Y,Liu X,Jiang L,Yang G,Sun X,Geng C,Li Q,Yao X,Chen M

Thu Aug 06 00:00:00 EDT 2015

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species.

Cell & bioscience

Wang H,Liu T,Li L,Wang Q,Yu C,Liu X,Li W

Thu May 14 00:00:00 EDT 2015

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species.

Cell & bioscience

Wang H,Liu T,Li L,Wang Q,Yu C,Liu X,Li W

Thu May 14 00:00:00 EDT 2015

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.

Oncotarget

Liu T,Men Q,Wu G,Yu C,Huang Z,Liu X,Li W

Fri Apr 10 00:00:00 EDT 2015

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.

Oncotarget

Liu T,Men Q,Wu G,Yu C,Huang Z,Liu X,Li W

Fri Apr 10 00:00:00 EDT 2015

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Toxicology letters

Shu G,Mi X,Cai J,Zhang X,Yin W,Yang X,Li Y,Chen L,Deng X

Thu Oct 24 00:00:00 EDT 2013

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Toxicology letters

Shu G,Mi X,Cai J,Zhang X,Yin W,Yang X,Li Y,Chen L,Deng X

Thu Oct 24 00:00:00 EDT 2013

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Toxicology letters

Shu G,Mi X,Cai J,Zhang X,Yin W,Yang X,Li Y,Chen L,Deng X

Thu Oct 24 00:00:00 EDT 2013

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Toxicology letters

Shu G,Mi X,Cai J,Zhang X,Yin W,Yang X,Li Y,Chen L,Deng X

Thu Oct 24 00:00:00 EDT 2013

Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma.

Proteomics

Liu Z,Chen C,Yang H,Zhang Y,Long J,Long X,Fang W

Thu Nov 01 00:00:00 EDT 2012

Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma.

Proteomics

Liu Z,Chen C,Yang H,Zhang Y,Long J,Long X,Fang W

Thu Nov 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692

View more View less

Gene Aliases: CatD; CD; CLN10; CPSD; CTSD; HEL-S-130P

View more View less

UniProt ID: (Human) P07339, (Mouse) P18242

View more View less

Entrez Gene ID: (Human) 1509, (Mouse) 13033, (Rat) 171293

View more View less

Function(s)

aspartic-type endopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity protein binding endopeptidase activity peptidase activity hydrolase activity peptide binding

Process(es)

proteolysis autophagy antigen processing and presentation of exogenous peptide antigen via MHC class II protein catabolic process collagen catabolic process autophagosome assembly epithelial tube branching involved in lung morphogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Cathepsin D Polyclonal Antibody

Cathepsin D Antibody (21327-1-AP) in ICC/IF

Product Details

21327-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!