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Product Details
PA5-85274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caveolin 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792417
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Dog (100%), Rhesus Monkey (100%), Bovine (100%).
Positive Control: Rat muscle, mouse muscle.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAV; Caveolin-3; M-caveolin; MGC126100; MGC126101; MGC126129
Gene Aliases: AI385751; Cav-3; CAV3; LGMD1C; LQT9; M-cav; VIP-21; VIP21
UniProt ID: (Human) P56539, (Rat) P51638, (Mouse) P51637
Entrez Gene ID: (Human) 859, (Rat) 29161, (Mouse) 12391
calcium channel regulator activity
protein binding
protein C-terminus binding
sodium channel regulator activity
potassium channel inhibitor activity
protein complex binding
protein complex scaffold
alpha-tubulin binding
ion channel binding
nitric-oxide synthase binding
connexin binding
enzyme binding
scaffold/adaptor protein
plasma membrane repair
regulation of heart rate
negative regulation of protein kinase activity
triglyceride metabolic process
endocytosis
muscle contraction
plasma membrane organization
actin filament organization
positive regulation of cytosolic calcium ion concentration
muscle organ development
myoblast fusion
regulation of heart contraction
protein localization
positive regulation of cell proliferation
negative regulation of cardiac muscle hypertrophy
positive regulation of myotube differentiation
regulation of skeletal muscle contraction
cell growth
regulation of transforming growth factor beta receptor signaling pathway
cell differentiation
positive regulation of microtubule polymerization
cytoplasmic microtubule organization
membrane raft organization
T-tubule organization
detection of muscle stretch
regulation of signal transduction by receptor internalization
regulation of membrane potential
glucose homeostasis
cholesterol homeostasis
negative regulation of MAP kinase activity
negative regulation of MAPK cascade
negative regulation of cell size
muscle cell cellular homeostasis
negative regulation of nitric-oxide synthase activity
regulation of nerve growth factor receptor activity
nucleus localization
regulation of protein kinase B signaling
negative regulation of calcium ion transport
cardiac muscle cell development
regulation of cardiac muscle contraction
negative regulation of sarcomere organization
regulation of ventricular cardiac muscle cell membrane repolarization
heart trabecula formation
regulation of ventricular cardiac muscle cell membrane depolarization
regulation of branching involved in mammary gland duct morphogenesis
negative regulation of cell growth involved in cardiac muscle cell development
caveola assembly
protein localization to plasma membrane
ventricular cardiac muscle cell action potential
establishment of protein localization to plasma membrane
regulation of calcium ion import
regulation of p38MAPK cascade
regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of potassium ion transmembrane transporter activity
regulation of calcium ion transmembrane transporter activity
negative regulation of potassium ion transmembrane transport
negative regulation of protein localization to cell surface
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of sodium ion transmembrane transporter activity
positive regulation of caveolin-mediated endocytosis
myotube differentiation
regulation of calcium ion transport
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