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Cbl-b Antibody (PA5-102547) in IHC (P)
Immunohistochemistry analysis of Cbl-b in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Cbl-b polyclonal antibody (Product # PA5-102547) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CBLB(Accession Q13191), corresponding to amino acid residues M1-V33.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2851949
Product Specific Information
Antibody detects endogenous levels of total CBLB.
Target Information
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; Casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B
Gene Aliases: AI429560; AI851073; Cbl-b; CBLB; Nbla00127; RNF56
UniProt ID: (Human) Q13191, (Rat) Q8K4S7, (Mouse) Q3TTA7
Entrez Gene ID: (Human) 868, (Rat) 171136, (Mouse) 208650
phosphotyrosine binding
ubiquitin-protein transferase activity
signal transducer activity
calcium ion binding
protein binding
zinc ion binding
ligase activity
protein kinase binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
damaged DNA-binding protein
ligase
metabolite interconversion enzyme
protein polyubiquitination
NLS-bearing protein import into nucleus
signal transduction
cell surface receptor signaling pathway
response to gravity
response to hormone
regulation of signaling
positive regulation of T cell anergy
immune response
protein ubiquitination
intracellular signal transduction
T cell activation
positive regulation of protein catabolic process
negative regulation of alpha-beta T cell proliferation
negative regulation of T cell receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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