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Product Details
TA590079
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Conjugate
Form
Liquid
Concentration
1.11314 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I
Gene Aliases: CGA; CHGA
UniProt ID: (Human) P10645
Entrez Gene ID: (Human) 1113
regulation of the force of heart contraction
mast cell chemotaxis
organelle organization
regulation of blood pressure
positive regulation of cAMP metabolic process
killing of cells of other organism
mast cell cytokine production
negative regulation of catecholamine secretion
ovulation cycle
mast cell degranulation
innate immune response
mast cell activation
negative regulation of vasodilation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive regulation of cardiac muscle contraction
adrenergic receptor signaling pathway involved in cardiac muscle relaxation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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