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Chromogranin A Antibody (MA5-42387) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Chromogranin A (red) in Hela cells using Chromogranin A Monoclonal Antibody (Product # MA5-42387). The nuclear counter stain is DAPI(blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
MA5-42387
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
D11-2
Immunogen
Synthetic peptide within human chromogranin-a aa 415-457
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911528
Product Specific Information
Positive Control: PC-12, Hela, LOVO, PANC-1, rat small intestine tissue, rat pancreas tissue, mouse pancreas tissue.
Subcellular Location: Secreted. Secretory vesicle lumen.
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I
Gene Aliases: CGA; CHGA; ChrA
UniProt ID: (Human) P10645, (Mouse) P26339
Entrez Gene ID: (Human) 1113, (Rat) 24258, (Mouse) 12652
regulation of the force of heart contraction
organelle organization
positive regulation of cAMP metabolic process
ovulation cycle
negative regulation of vasodilation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
mast cell chemotaxis
regulation of blood pressure
killing of cells of other organism
mast cell cytokine production
negative regulation of catecholamine secretion
mast cell degranulation
innate immune response
mast cell activation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive regulation of cardiac muscle contraction
adrenergic receptor signaling pathway involved in cardiac muscle relaxation
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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