Proteintech

Claudin 3 Polyclonal Antibody

Claudin 3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Claudin 3 Antibody (16456-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 16456-1-AP ( Claudin 3 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Claudin 3 Antibody in Immunoprecipitation (IP)

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Product Details

16456-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Claudin 3 Fusion Protein Ag9411 (1-220 aa encoded by BC016056)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSMGLEITG TALAVLGWLG TIVCCALPMW RVSAFIGSNI ITSQNIWEGL WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVVAILL AAFGLLVALV GAQCTNCVQD DTAKAKITIV AGVLFLLAAL LTLVPVSWSA NTIIRDFYNP VVPEAQKREM GAGLYVGWAA AALQLLGGAL LCCSCPPREK KYTATKVVYS APRSTGPGAS LGTGYDRKDY V (1-220 aa encoded by BC016056)

Target Information

Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Open hepatic artery flow with portal vein clamping protects against bile duct injury compared to pringles maneuver.

Scandinavian journal of gastroenterology

Zhang S,Cao P,Bi P,Yang F,Wu M,Luo D,Yang B

Sat Jul 01 00:00:00 EDT 2023

Open hepatic artery flow with portal vein clamping protects against bile duct injury compared to pringles maneuver.

Scandinavian journal of gastroenterology

Zhang S,Cao P,Bi P,Yang F,Wu M,Luo D,Yang B

Sat Jul 01 00:00:00 EDT 2023

Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.

Environmental science and pollution research international

Huang L,Liu B,Yu XW,Pan GQ,Xu JY,Yan D,Wang YL,Guo QN

Mon May 01 00:00:00 EDT 2023

Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.

Journal of biochemical and molecular toxicology

Wang Y,Zhang L,Lv L,Zhou Z,Xi H

Thu Jun 01 00:00:00 EDT 2023

Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.

Journal of biochemical and molecular toxicology

Wang Y,Zhang L,Lv L,Zhou Z,Xi H

Thu Jun 01 00:00:00 EDT 2023

A high-sucrose diet causes microbiota composition shift and promotes the susceptibility of mice to Salmonella Typhimurium infection.

Food & function

Liu J,Liu H,Teng Y,Qin N,Ren X,Xia X

Mon Mar 20 00:00:00 EDT 2023

Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice.

Journal of advanced research

Liu J,Liu H,Liu H,Teng Y,Qin N,Ren X,Xia X

Sun Oct 01 00:00:00 EDT 2023

Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice.

Journal of advanced research

Liu J,Liu H,Liu H,Teng Y,Qin N,Ren X,Xia X

Sun Oct 01 00:00:00 EDT 2023

Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.

Chemico-biological interactions

Li J,Bai J,Si X,Jia H,Wu Z

Sat Apr 01 00:00:00 EDT 2023

JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling.

Antioxidants (Basel, Switzerland)

Zhou Y,Liu J,Li X,Wang L,Hu L,Li A,Zhou J

Fri May 27 00:00:00 EDT 2022

JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling.

Antioxidants (Basel, Switzerland)

Zhou Y,Liu J,Li X,Wang L,Hu L,Li A,Zhou J

Fri May 27 00:00:00 EDT 2022

Integrated Profiles of Transcriptome and mRNA m6A Modification Reveal the Intestinal Cytotoxicity of Aflatoxin B1 on HCT116 Cells.

Genes

Wu Y,Bao W,Ren J,Li C,Chen M,Zhang D,Zhu A

Tue Dec 27 00:00:00 EST 2022

Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice.

Molecular biology reports

Tsurudome Y,Morita N,Horiguchi M,Ushijima K

Thu Dec 01 00:00:00 EST 2022

Phytic Acid Improves Hepatic Steatosis, Inflammation, and Oxidative Stress in High-Fat Diet (HFD)-Fed Mice by Modulating the Gut-Liver Axis.

Journal of agricultural and food chemistry

Ran X,Hu G,He F,Li K,Li F,Xu D,Liu J,Fu S

Wed Sep 14 00:00:00 EDT 2022

Zhibai Dihuang Pill Alleviates Ureaplasma urealyticum-Induced Spermatogenic Failure and Testicular Dysfunction via MAPK Signaling Pathway.

Computational and mathematical methods in medicine

Zhang K,Guo J,Zhu Y,Zhang R

Tue Mar 22 00:00:00 EDT 2022

Sanhuang Xiexin decoction ameliorates DSS-induced colitis in mice by regulating intestinal inflammation, intestinal barrier, and intestinal flora.

Journal of ethnopharmacology

Wu X,Fu S,Jiang M,Wang J,Tang H,Fang C,Li W,Fu C

Fri Oct 28 00:00:00 EDT 2022

Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota.

Molecular nutrition & food research

Guo X,Xu Y,Geng R,Qiu J,He X

Fri Apr 01 00:00:00 EDT 2022

Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Matsuoka S,Suzuki H,Kato C,Kamikawa-Tokai M,Kamikawa A,Okamatsu-Ogura Y,Kimura K

Tue Jun 01 00:00:00 EDT 2021

Immune infiltration profiling in gastric cancer and their clinical implications.

Cancer science

Ren F,Zhao Q,Zhao M,Zhu S,Liu B,Bukhari I,Zhang K,Wu W,Fu Y,Yu Y,Tang Y,Zheng P,Mi Y

Wed Sep 01 00:00:00 EDT 2021

Immune infiltration profiling in gastric cancer and their clinical implications.

Cancer science

Ren F,Zhao Q,Zhao M,Zhu S,Liu B,Bukhari I,Zhang K,Wu W,Fu Y,Yu Y,Tang Y,Zheng P,Mi Y

Wed Sep 01 00:00:00 EDT 2021

Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts.

Aging cell

Chen Z,Xiong L,Jin H,Yu J,Li X,Fu H,Wen L,Qi H,Tong C,Saffery R,Kilby MD,Baker PN

Thu Jul 01 00:00:00 EDT 2021

Altered protein S-glutathionylation depicts redox imbalance triggered by transition metal oxide nanoparticles in a breastfeeding system.

NanoImpact

Cai J,Zang X,Wu Z,Liu J,Wang D

Thu Apr 01 00:00:00 EDT 2021

Whole transcriptome-based ceRNA network analysis revealed ochratoxin A-induced compromised intestinal tight junction proteins through WNT/Ca²⁺ signaling pathway.

Ecotoxicology and environmental safety

Yang X,Gao Y,Huang S,Su C,Wang J,Zheng N

Fri Aug 20 00:00:00 EDT 2021

Whole transcriptome-based ceRNA network analysis revealed ochratoxin A-induced compromised intestinal tight junction proteins through WNT/Ca²⁺ signaling pathway.

Ecotoxicology and environmental safety

Yang X,Gao Y,Huang S,Su C,Wang J,Zheng N

Fri Aug 20 00:00:00 EDT 2021

Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.

American journal of translational research

Zhang S,Sharaf Eldin HE,Gu WL,Li TS

Tue Dec 28 00:00:00 EST 2021

BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.

Mediators of inflammation

Wan Y,Song M,Xie X,Chen Z,Gao Z,Wu X,Huang R,Chen M

Thu Mar 31 00:00:00 EDT 2022

BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.

Mediators of inflammation

Wan Y,Song M,Xie X,Chen Z,Gao Z,Wu X,Huang R,Chen M

Thu Mar 31 00:00:00 EDT 2022

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.

Neurochemical research

Tang B,Song M,Xie X,Le D,Tu Q,Wu X,Chen M

Wed Sep 01 00:00:00 EDT 2021

Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.

Journal of thermal biology

Guo H,He J,Yang X,Zheng W,Yao W

Wed Apr 01 00:00:00 EDT 2020

Tandem mass tag (TMT) proteomic analysis of fetal lungs revealed differential expression of tight junction proteins in a rat model of congenital diaphragmatic hernia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li X,Liu H,Yu W,Liu X,Liu C

Wed Jan 01 00:00:00 EST 2020

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Journal of hazardous materials

Wu J,Lai X,Cui G,Chen Q,Liu J,Kang Y,Zhang Y,Feng X,Hu C,Shao L

Sun Nov 15 00:00:00 EST 2020

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Journal of hazardous materials

Wu J,Lai X,Cui G,Chen Q,Liu J,Kang Y,Zhang Y,Feng X,Hu C,Shao L

Sun Nov 15 00:00:00 EST 2020

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Journal of hazardous materials

Wu J,Lai X,Cui G,Chen Q,Liu J,Kang Y,Zhang Y,Feng X,Hu C,Shao L

Sun Nov 15 00:00:00 EST 2020

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Journal of hazardous materials

Wu J,Lai X,Cui G,Chen Q,Liu J,Kang Y,Zhang Y,Feng X,Hu C,Shao L

Sun Nov 15 00:00:00 EST 2020

Translocation of transition metal oxide nanoparticles to breast milk and offspring: The necessity of bridging mother-offspring-integration toxicological assessments.

Environment international

Cai J,Zang X,Wu Z,Liu J,Wang D

Sun Dec 01 00:00:00 EST 2019

Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.

EMBO molecular medicine

Zhao M,Xiong X,Ren K,Xu B,Cheng M,Sahu C,Wu K,Nie Y,Huang Z,Blumberg RS,Han X,Ruan HB

Wed Aug 01 00:00:00 EDT 2018

Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.

EMBO molecular medicine

Zhao M,Xiong X,Ren K,Xu B,Cheng M,Sahu C,Wu K,Nie Y,Huang Z,Blumberg RS,Han X,Ruan HB

Wed Aug 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: Claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; hRVP1; Rat ventral prostate.1 protein; Rat ventral prostate.1 protein homolog; RVP1; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein

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Gene Aliases: AI182374; C7orf1; CLDN3; CPE-R2; CPETR2; HRVP1; mRVP1; RVP1

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UniProt ID: (Human) O15551, (Rat) Q63400, (Mouse) Q9Z0G9

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Entrez Gene ID: (Human) 1365, (Rat) 65130, (Mouse) 12739

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Function(s)

transmembrane signaling receptor activity structural molecule activity identical protein binding protein binding tight junction

Process(es)

response to hypoxia epithelial cell morphogenesis signal transduction calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules protein homooligomerization protein heterooligomerization bicellular tight junction assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Claudin 3 Polyclonal Antibody

Claudin 3 Antibody (16456-1-AP) in IHC (P)

Product Details

16456-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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