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Invitrogen
Clostridium tetani Tetanus Toxin VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1236)
Product Details
MA5-54316
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1236
Immunogen
Recombinant Clostridium tetani tetX/Tetanus toxin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Compatible with Direct ELISA
Target Information
Tetanus toxin is a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C. tetani; Tetanus Toxin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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