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Product Details
12289-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Clusterin Fusion Protein Ag2889 (101-449 aa encoded by BC010514)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VCNETMMAL WEECKPCLKQ TCMKFYARVC RSGSGLVGRQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ THMLDVMQDH FSRASSIIDE LFQDRFFTRE PQDTYHYLPF SLPHRRPHFF FPKSRIVRSL MPFSPYEPLN FHAMFQPFLE MIHEAQQAMD IHFHSPAFQH PPTEFIREGD DDRTVCREIR HNSTGCLRMK DQCDKCREIL SVDCSTNNPS QAKLRRELDE SLQVAERLTR KYNELLKSYQ WKMLNTSSLL EQLNEQFNWV SRLANLTQGE DQYYLRVTTV ASHTSDSDVP SGVTEVVVKL FDSDPITVTV PVEVSRKNPK FMETVAEKAL QEYRKKHREE (101-449 aa encoded by BC010514)
Target Information
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aging associated protein 4; Aging-associated gene 4 protein; aging-associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; Apo-J; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; Apolipoprotein J; CLI; Clusterin; Clusterin alpha / beta chain; Clustrin; Complement associated protein SP40; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40,40; DAG; Dimeric acid glycoprotein; GP80; HGNC:2095; Ku70-binding protein 1; Ku70-binding protein 1 (KUB1); MGC24903; NA1/NA2; SGP-2; Sulfated glycoprotein 2; Sulfated glycoprotein 2 (SGP2); testosterone repressed prostate message; Testosterone repressed prostate message 2; Testosterone repressed prostate message 2 (TPRM2B); testosterone repressed prostate message-2; testosterone-repressed prostate message; Testosterone-repressed prostate message 2; testostrone-repressed prostate message 2; TRPM-2
Gene Aliases: AAG4; AI893575; APO-J; APOJ; CLI; CLU; CLU1; CLU2; D14Ucla3; DAG; KUB1; Msgp-2; NA1/NA2; RATTRPM2B; SGP-2; SGP2; SP-40; SP40; Sugp-2; TRPM-2; TRPM2; TRPM2B; Trpmb
UniProt ID: (Human) P10909, (Rat) P05371, (Mouse) Q06890
Entrez Gene ID: (Human) 1191, (Rat) 24854, (Mouse) 12759
cell morphogenesis
microglial cell activation
response to oxidative stress
spermatogenesis
aging
positive regulation of cell proliferation
response to light stimulus
response to wounding
response to virus
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
response to potassium ion
positive regulation of apoptotic process
negative regulation of apoptotic process
estrous cycle
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
cellular response to growth factor stimulus
intrinsic apoptotic signaling pathway
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
cell death
release of cytochrome c from mitochondria
platelet degranulation
lipid metabolic process
complement activation
complement activation, classical pathway
reverse cholesterol transport
innate immune response
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