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Product Details
CO20121-01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified collagen type I from bovine skin
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Bovine skin or liver.
Cross-reacting with sheep, swine and human (IHC).
Target Information
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-1 type I collagen; Alpha-2 type I collagen; COL1; collagen 1 alpha 2 chain; Collagen alpha-1(I) chain; Collagen alpha-2(I) chain; collagen, type I, alpha 1; collagen, type I, alpha 2; Type I Collagen
Gene Aliases: COL1A1; COL1A2
UniProt ID: (Bovine) P02453, (Bovine) P02465
Entrez Gene ID: (Bovine) 282187, (Bovine) 282188
osteoblast differentiation
intramembranous ossification
endochondral ossification
visual perception
sensory perception of sound
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
protein transport
collagen fibril organization
positive regulation of cell migration
collagen biosynthetic process
protein localization to nucleus
tooth mineralization
skin morphogenesis
positive regulation of transcription, DNA-templated
embryonic skeletal system development
face morphogenesis
bone trabecula formation
cartilage development involved in endochondral bone morphogenesis
cellular response to amino acid stimulus
cellular response to mechanical stimulus
positive regulation of canonical Wnt signaling pathway
skeletal system development
blood vessel development
transforming growth factor beta receptor signaling pathway
Rho protein signal transduction
regulation of blood pressure
bone mineralization
collagen metabolic process
protein heterotrimerization
extracellular matrix assembly
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