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Invitrogen
CtBP1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
CtBP1 Antibody (PA5-82651) in ICC/IF
Immunofluorescence analysis of CtBP1 was performed using 70% confluent log phase A549 cells. The cells were fixed with 4% paraformaldehyde for overnight, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with CtBP1 Polyclonal Antibody (Product # PA5-82651) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), ... View More
Product Details
PA5-82651
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CTBP1. Recombinant protein control fragment (Product #RP-92546).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789807
Product Specific Information
Immunogen sequence: YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL
Target Information
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684
Gene Aliases: BARS; CTBP; CTBP1
UniProt ID: (Human) Q13363
Entrez Gene ID: (Human) 1487
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
transcription factor binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein domain specific binding
protein homodimerization activity
NAD binding
repressing transcription factor binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of cell proliferation
viral genome replication
positive regulation of histone deacetylation
negative regulation of histone acetylation
negative regulation of transcription, DNA-templated
white fat cell differentiation
regulation of cell cycle
oxidation-reduction process
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter by histone modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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