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Product Details
PA5-106258
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CTBP1(Accession Q13363), corresponding to amino acid residues T132-L182.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817644
Product Specific Information
Antibody detects endogenous levels of total CtBP1/2.
Target Information
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; BARS-50; brefeldin A-ADP-riboslyated substrate; brefeldin A-ribosylated substrate; C-terminal-binding protein 1; C-terminal-binding protein 2; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; CtBP1; CtBP2; CtBP3; gene trap ROSA b-geo 6; ribeye
Gene Aliases: 50-kDaBFA-inducedADP-ribosylatedsubstrate; AA407280; BARS; BARS-50; CTBP; CTBP1; CtBP1-L; CtBP1-S; CTBP2; Ctbp3; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E; D7Ertd45e; Gtrgeo6; Ribeye
UniProt ID: (Human) Q13363, (Human) P56545, (Rat) Q9Z2F5, (Mouse) O88712, (Rat) Q9EQH5, (Mouse) P56546
Entrez Gene ID: (Human) 1487, (Human) 1488, (Rat) 29382, (Mouse) 13016, (Rat) 81717, (Mouse) 13017
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
transcription factor binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein domain specific binding
protein homodimerization activity
NAD binding
repressing transcription factor binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
retinoic acid receptor binding
transferase activity, transferring acyl groups
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
aldo-keto reductase (NADP) activity
isocitrate dehydrogenase activity
mevaldate reductase activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
oxidoreductase activity
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of cell proliferation
viral genome replication
positive regulation of histone deacetylation
negative regulation of histone acetylation
negative regulation of transcription, DNA-templated
white fat cell differentiation
regulation of cell cycle
oxidation-reduction process
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter by histone modification
positive regulation of chromatin binding
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
membrane fusion
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
metabolic process
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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