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Product Details
19538-1-AP
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; chemokine (C-X-C) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor alpha chain; Il-8 receptor b; IL-8 receptor beta; IL-8R B; interleukin 8 receptor, beta; interleukin-8 receptor type B
Gene Aliases: CD128; CDw128; Cmkar2; Cxcr2; Gpcr16; IL-8rb; IL-8Rh; IL8RA; Il8rb; mIL-8RH
UniProt ID: (Mouse) P35343
Entrez Gene ID: (Mouse) 12765
acute inflammatory response to antigenic stimulus
positive regulation of leukocyte chemotaxis
chemotaxis
cellular defense response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of cardiac muscle cell apoptotic process
neutrophil chemotaxis
receptor internalization
negative regulation of neutrophil apoptotic process
interleukin-8-mediated signaling pathway
neutrophil activation
negative regulation of apoptotic process
positive regulation of vascular permeability
positive regulation of angiogenesis
chemokine-mediated signaling pathway
metanephric tubule morphogenesis
positive regulation of neutrophil chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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