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Cyclin A2 Monoclonal Antibody (1C6C11)

Cyclin A2 Antibody in Immunocytochemistry (ICC/IF)

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Cyclin A2 Antibody (66391-1-IG) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 66391-1-IG (Cyclin A2 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

Cyclin A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

66391-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:4,000

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1C6C11

Immunogen

Cyclin A2 Fusion Protein Ag12765 (1-432 aa encoded by BC104783)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLGNSAPGP ATREAGSALL ALQQTALQED QENINPEKAA PVQQPRTRAA LAVLKSGNPR GLAQQQRPKT RRVAPLKDLP VNDEHVTVPP WKANSKQPAF TIHVDEAEKE AQKKPAESQK IEREDALAFN SAISLPGPRK PLVPLDYPMD GSFESPHTMD MSIVLEDEKP VSVNEVPDYH EDIHTYLREM EVKCKPKVGY MKKQPDITNS MRAILVDWLV EVGEEYKLQN ETLHLAVNYI DRFLSSMSVL RGKLQLVGTA AMLLASKFEE IYPPEVAEFV YITDDTYTKK QVLRMEHLVL KVLTFDLAAP TVNQFLTQYF LHQQPANCKV ESLAMFLGEL SLIDADPYLK YLPSVIAGAA FHLALYTVTG QSWPESLIRK TGYTLESLKP CLMDLHQTYL KAPQHAQQSI REKYKNSKYH GVSLLNPPET LNL (1-432 aa encoded by BC104783)

Target Information

Cyclins are regulatory subunits of the cyclin-dependent kinases (cdks) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdks. These cyclin / cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S phase and passage through G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.

International journal of oncology

Song Y,Guo D,Liu JF,Ge LN,Liu P,Qu YM,Cong HY,Li T,Chang X,Wang YR,Shao LY,Du ZJ,Wang MY

Sat Jul 01 00:00:00 EDT 2023

Osteogenic microenvironment affects palatal development through glycolysis.

Differentiation; research in biological diversity

Peng X,Chen J,Wang Y,Wang X,Zhao X,Zheng X,Wang Z,Yuan D,Du J

Thu Nov 02 00:00:00 EDT 2023

Upregulation of HCFC1 expression promoted hepatocellular carcinoma progression through inhibiting cell cycle arrest and correlated with immune infiltration.

Journal of Cancer

Wang H,Yu M,Yang C,Li Q

Thu Jun 08 00:00:00 EDT 2023

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis.

eLife

Li E,Xia M,Du Y,Long K,Ji F,Pan F,He L,Hu Z,Guo Z

Tue May 03 00:00:00 EDT 2022

HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.

Journal of experimental & clinical cancer research : CR

Guo K,Ma Z,Zhang Y,Han L,Shao C,Feng Y,Gao F,Di S,Zhang Z,Zhang J,Tabbò F,Ekman S,Suda K,Cappuzzo F,Han J,Li X,Yan X

Fri Mar 11 00:00:00 EST 2022

Paradol Induces Cell Cycle Arrest and Apoptosis in Glioblastoma Cells.

Nutrition and cancer

Wang R,Liu T,Chen J,Zhang D

Tue Jul 26 00:00:00 EDT 2022

Alpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling.

European journal of pharmacology

Xiao X,Zhang Y,Tian S,Wang X,Zhang Q,Zhang L,Yu X,Ma C,Zheng X,Li Y,Zhang J,Qu L

Thu Sep 15 00:00:00 EDT 2022

Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation.

BMC cardiovascular disorders

Meng Q,Xu Y,Ling X,Liu H,Ding S,Wu H,Yan D,Fang X,Li T,Liu Q

Fri Jul 29 00:00:00 EDT 2022

Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.

Chemico-biological interactions

Tan J,Sun M,Yin J,Zhou Q,Zhao R,Chen Q,Sun H,Jiang C,Li S,He Y

Thu Dec 01 00:00:00 EST 2022

NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.

Journal of cellular and molecular medicine

Hu B,Zhou S,Hu X,Zhang H,Lan X,Li M,Wang Y,Hu Q

Sun May 16 00:00:00 EDT 2021

Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.

Journal of cellular and molecular medicine

Cui XH,Peng QJ,Li RZ,Lyu XJ,Zhu CF,Qin XH

Wed Dec 01 00:00:00 EST 2021

Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.

Nutrition and cancer

Zhang D,Li C,Zhang L,Li B,Wang Y,Wang R,Chen Z,Xu L,Liu T

Thu Feb 24 00:00:00 EST 2022

Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.

Evidence-based complementary and alternative medicine : eCAM

Han Y,Ma R,Cao G,Liu H,He L,Tang L,Li H,Luo Q

Tue Jun 15 00:00:00 EDT 2021

Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation.

Developmental cell

Merta H,Carrasquillo Rodríguez JW,Anjur-Dietrich MI,Vitale T,Granade ME,Harris TE,Needleman DJ,Bahmanyar S

Mon Dec 20 00:00:00 EST 2021

Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.

Fitoterapia

Jin J,Zhou M,Wang X,Liu M,Huang H,Yan F,Yu Z,Shu X,Huo X,Feng L,Zhang B,Huang S,Deng S,Wang C,Ma X

Fri Jan 01 00:00:00 EST 2021

A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.

Frontiers in pharmacology

Pan B,Wang Y,Wu C,Jia J,Huang C,Fang S,Liu L

Sat Jan 30 00:00:00 EST 2021

KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.

Oncogene

Zhong Y,Yang J,Xu WW,Wang Y,Zheng CC,Li B,He QY

Thu Nov 02 00:00:00 EDT 2017

KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.

Oncogene

Zhong Y,Yang J,Xu WW,Wang Y,Zheng CC,Li B,He QY

Thu Nov 02 00:00:00 EDT 2017

The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.

Toxicology letters

Yang J,Qiao L,Zeng Z,Wang J,Zhu T,Wei J,Wu M,Ye S,Huang X,Ma D,Liu R,Gao Q

Wed Jan 04 00:00:00 EST 2017

The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.

Toxicology letters

Yang J,Qiao L,Zeng Z,Wang J,Zhu T,Wei J,Wu M,Ye S,Huang X,Ma D,Liu R,Gao Q

Wed Jan 04 00:00:00 EST 2017

Enterovirus 71 mediates cell cycle arrest in S phase through non-structural protein 3D.

Cell cycle (Georgetown, Tex.)

Yu J,Zhang L,Ren P,Zhong T,Li Z,Wang Z,Li J,Liu X,Zhao K,Zhang W,Yu XF

Wed Dec 02 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Cyclin A; Cyclin-A; Cyclin-A2

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Gene Aliases: CCN1; CCNA; CCNA2

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UniProt ID: (Human) P20248

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Entrez Gene ID: (Human) 890

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Function(s)

protein binding protein kinase binding kinase activator

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity mitotic nuclear division mitotic G2 DNA damage checkpoint Ras protein signal transduction viral process organ regeneration response to glucagon cellular response to platelet-derived growth factor stimulus cellular response to leptin stimulus positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation cell division cellular response to cocaine cellular response to luteinizing hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to nitric oxide cochlea development cellular response to insulin-like growth factor stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cyclin A2 Monoclonal Antibody (1C6C11)

Cyclin A2 Antibody (66391-1-IG) in ICC/IF

Product Details

66391-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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