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Invitrogen
Cyclophilin A Polyclonal Antibody
Advanced Verification
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.
Product Details
PA5-29752
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 165 of Human Cyclophilin A
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547226
Product Specific Information
Recommended positive controls: Raji WCE, Raji C+M, Raji NE, Molt-4, Raji, Mouse brain.
Predicted reactivity: Mouse (96%), Rat (96%), Cat (98%), Pig (99%), Rabbit (96%), Chicken (92%), Sheep (99%), Rhesus Monkey (100%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HGNC:9253; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIase A; rotamase; Rotamase A; SP18; T cell cyclophilin
Gene Aliases: 2700098C05; Cphn; CYCA; CyP-18; CyP-A; CYPA; CYPH; HEL-S-69p; PPIA
UniProt ID: (Human) P62937, (Mouse) P17742, (Rat) P10111
Entrez Gene ID: (Human) 5478, (Mouse) 268373, (Rat) 25518
protein peptidyl-prolyl isomerization
RNA-dependent DNA biosynthetic process
protein folding
viral life cycle
uncoating of virus
fusion of virus membrane with host plasma membrane
virion assembly
viral release from host cell
entry into host cell
lipid particle organization
regulation of viral genome replication
positive regulation of viral genome replication
positive regulation of protein secretion
leukocyte migration
establishment of integrated proviral latency
neuron differentiation
negative regulation of protein phosphatase type 2B activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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