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Invitrogen
Cytokeratin 16 Recombinant Rabbit Monoclonal Antibody (8L6R4)
FIGURE: 1 / 5
Cytokeratin 16 Antibody (MA5-42892) in IHC (P)
Immunohistochemistry analysis of Cytokeratin 16 in paraffin-embedded human esophageal cancer. Samples were incubated with Cytokeratin 16 Monoclonal antibody (Product # MA5-42892) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-42892
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8L6R4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cytokeratin 16 (KRT16) (P08779).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912033
Product Specific Information
Positive test controls include: Mouse large intestine.
Immunogen sequence: MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSRFSSGG ACGLGGGYGG GFSSSSSFGS GFGGGYGGGL GAGFGGGLGA
Target Information
KRT16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CK-16; cytokeratin 16; Cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma; K16; keratin 16, type I; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin, type I cytoskeletal 16; Keratin-16; type I keratin KA16
Gene Aliases: AI324768; CK16; FNEPPK; K16; K1CP; Ka16; Krt1-16; KRT16; KRT16A; NEPPK; PC1
UniProt ID: (Human) P08779, (Mouse) Q9Z2K1
Entrez Gene ID: (Human) 3868, (Mouse) 16666, (Rat) 303530
morphogenesis of an epithelium
immune system process
inflammatory response
aging
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
biological_process
cytoskeleton organization
cell proliferation
epidermis development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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