Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Cytokeratin 5/8 Monoclonal Antibody (C-50)
Product Details
MA1-19031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Hamster,
Human,
Mouse,
Sheep,
Pig,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C-50
Immunogen
Cytoskeleton preparation from HeLa cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2281093
Product Specific Information
This antibody reacts with cytokeratin peptides 5 and 8 (58 and 53 kDa). Cytokeratins are members of intermediate filaments subfamily of intracellular proteins represented in epithelial tissues.
This antibody will not cross-react with Xenopus or chicken.
Target Information
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between ~40 kDa and ~68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 58 kDa cytokeratin; CK-5; CK-8; cytokeratin 5; cytokeratin 8; Cytokeratin endo A; cytokeratin type II, component III; Cytokeratin-5; Cytokeratin-8; Cytokeratin-A; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; K8; KERA; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 8; keratin 8, type II; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 8; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8-like protein; Keratin-5; Keratin-8; krt5; tuftelin interacting protein 8; type II cytokeratin A (no.8); Type-II keratin Kb5; Type-II keratin Kb8
Gene Aliases: 3300001P10Rik; AA960620; AL022697; AU019895; AW146334; CARD2; CK-8; CK5; CK8; CYK8; CYKER; DDD; DDD1; EBS2; EndoA; K2C8; K5; K8; KO; Krt-2.8; Krt2-5; KRT2-8; KRT5; KRT5A; KRT8; Sak57; Tfip8
epithelial cell differentiation
negative regulation of epithelial cell proliferation
cell morphogenesis involved in differentiation
multicellular organism development
tumor necrosis factor-mediated signaling pathway
sarcomere organization
response to hydrostatic pressure
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
biological_process
viral process
cytoskeleton organization
epidermis development
hemidesmosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support