Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Cytokeratin 6 Monoclonal Antibody (Ks6.KA12)
Product Details
MA1-35561
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Ks6.KA12
Immunogen
Keratin K6 of human callus cytoskeletal preparation
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2134292
Product Specific Information
The antibody represents an excellent marker for non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions).Polypeptide Reacting: Mr 56 000 polypeptide (cytokeratin 6) of human squamous epithelia. Tissues and Tumors specifically detected: The antibody is suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma.
Target Information
Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60-kDa keratin; CK-6A; CK-6B; CK-6C; CK-6D; CK-6E; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; K6A; K6B; K6C; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 6A, , type II; keratin 6A, type II; keratin 6B, type II; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; Keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; Keratin-6-alpha; keratin-6-beta; Keratin-6A; Keratin-6B; Keratin-6C; keratin-like 1 (a type II keratin sequence); mK6-alpha; mK6-beta; Type-II keratin Kb10; Type-II keratin Kb12; Type-II keratin Kb6
Gene Aliases: 2310016L08Rik; BB144589; CK-6B; CK-6C; CK-6E; CK6A; CK6B; CK6C; CK6D; K6A; K6B; K6C; K6D; K6E; Ker2; Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; KRTL1; mK6[a]; mK6[b]; MK6a; PC2; PC3; PC4; PPKNEFD
UniProt ID: (Human) P02538, (Human) P04259, (Human) P48668, (Mouse) P50446
Entrez Gene ID: (Human) 3853, (Human) 3854, (Human) 286887, (Mouse) 16687, (Mouse) 16688
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support