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Invitrogen
Cytokeratin 8 Monoclonal Antibody (C-43)
Product Details
MA1-19037
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Sheep,
Pig,
Rabbit
Published species
Goat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C-43
Immunogen
Cytoskeleton preparation from HeLa human cervix carcinoma cell line
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1075193
Product Specific Information
This antibody reacts with cytokeratin 8 (52.5 kDa intracellular antigen). Cytokeratins are members of intermediate filaments subfamily represented in epithelial tissues.
This antibody will not cross-react with hamster, mouse, Xenopus, rat or chicken.
Target Information
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CK-8; cytokeratin 8; Cytokeratin-8; Cytokeratin-A; K8; KERA; keratin 8, type II; Keratin, type II cytoskeletal 8; Keratin-8; type II cytokeratin A (no.8); Type-II keratin Kb8
Gene Aliases: CARD2; CK-8; CK8; CYK8; K2C8; K8; KO; KRT2-8; KRT8
UniProt ID: (Bovine) P05786, (Human) P05787
Entrez Gene ID: (Rabbit) 100348891, (Bovine) 281269, (Pig) 100152077, (Human) 3856, (Sheep) 101110495
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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