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NeoBiotechnologies
Cytokeratin, Acidic (Type I or LMW) Recombinant Rabbit Monoclonal Antibody (KRTL, 1577R)
Product Details
RBM21-1577-P1
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
KRTL, 1577R
Immunogen
Recombinant human KRT77 protein fragment
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
This antibody is expected to show broad species reactivity.
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40-kDa keratin intermediate filament; Acidic Cytokeratin; Cell proliferation-inducing gene 46 protein; CK-10; CK-14; CK-15; CK-16; CK-18; CK-19; CK-9; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 9; Cytokeratin-10; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-18; Cytokeratin-19; Cytokeratin-9; epithelial keratin 10; Epithelial keratin-10; focal non-epidermolytic palmoplantar keratoderma; HMWCK; K10; K14; K15; K16; K18; K19; K9; keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 14, type I; keratin 15, type I; keratin 16 (focal non-epidermolytic palmoplantar keratoderma); keratin 16, type I; keratin 18, type I; keratin 19, type I; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; Keratin-10; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-18; Keratin-19; Keratin-9; pan keratin; pankeratin; type I cytoskeletal 15; type I cytoskeletal 9
Gene Aliases: BCIE; BIE; CK-10; CK-18; CK-9; CK10; CK14; CK15; CK16; CK18; CK19; CYK18; EBS3; EBS4; EHK; EPPK; FNEPPK; K10; K14; K15; K16; K18; K19; K1CO; K1CP; K1CS; K9; KER10; KPP; KRT10; KRT14; KRT15; KRT16; KRT16A; KRT18; KRT19; KRT9; KRTB; NEPPK; NFJ; PC1; PIG46
structural constituent of epidermis
protein heterodimerization activity
structural constituent of cytoskeleton
protein binding
keratin filament binding
scaffold protein binding
structural molecule activity
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
protein complex binding
Notch signaling pathway
viral process
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
cell cycle
anatomical structure morphogenesis
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane CFTR protein transport
negative regulation of apoptotic process
intermediate filament cytoskeleton organization
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell-cell adhesion
morphogenesis of an epithelium
inflammatory response
cytoskeleton organization
aging
cell proliferation
epidermis development
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
keratinocyte migration
establishment of skin barrier
mitophagy in response to mitochondrial depolarization
skin development
intermediate filament organization
response to zinc ion
response to ionizing radiation
epithelial cell differentiation
hemidesmosome assembly
intermediate filament bundle assembly
peptide cross-linking
positive regulation of epidermis development
protein heterotetramerization
spermatogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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