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Product Details
BS-14193R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DAND5, amino acids 101-189.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CER2CRL2; cerberus 2; Cerberus like-2; cerberus-like 2; Cerberus-like protein 2; Cerl-2; CKTSF1B3MGC126849; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain family member 5; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; FLJ38607; GREM3cerberus 2; Gremlin-3; MGC126849
Gene Aliases: CER2; CERL2; CKTSF1B3; COCO; CRL2; DAND5; DANTE; GREM3; SP1
UniProt ID: (Human) Q8N907
Entrez Gene ID: (Human) 199699
determination of left/right asymmetry in lateral mesoderm
ventricular septum development
atrial septum development
signal transduction involved in regulation of gene expression
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of nodal from receptor via nodal binding
determination of heart left/right asymmetry
negative regulation of nodal signaling pathway
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
Performance Guarantee
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