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FIGURE: 1 / 8
DCK Antibody (MA5-27740) in ICC/IF
DCK Monoclonal Antibody (GT10412) detects DCK protein at nucleus by immunofluorescent analysis. Sample: HCT 116 cells were fixed in 4% paraformaldehyde at RT for 15 min. Red: DCK protein stained by DCK Monoclonal Antibody (GT10412) (Product # MA5-27740) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
MA5-27740
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT10412
Immunogen
Recombinant protein encompassing a sequence within the center region of human DCK. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
2.01 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735161
Product Specific Information
Positive Control: A431, HeLa, HepG2, 293T, A549, H1299, HCT116, Neuro 2A, C8D30, NIH-3T3, Raw264.7, PC-12, Rat2
Predicted Reactivity: Rhesus Monkey (96%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dCK; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; deoxynucleoside kinase
Gene Aliases: DCK
UniProt ID: (Human) P27707, (Mouse) P43346, (Rat) P48769
Entrez Gene ID: (Human) 1633, (Mouse) 13178, (Rat) 79127
pyrimidine nucleotide metabolic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
phosphorylation
pyrimidine nucleoside salvage
purine-containing compound salvage
nucleobase-containing compound metabolic process
drug metabolic process
deoxycytidine metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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