Proteintech

DCT Polyclonal Antibody

DCT Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DCT Antibody (13095-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skin using 13095-1-AP (DCT antibody) at dilution of 1:100 (under 40x lens).

DCT Antibody in Immunoprecipitation (IP)

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Product Details

13095-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DCT Fusion Protein Ag3714 (1-350 aa encoded by BC028311)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSPLWWGFL LSCLGCKILP GAQGQFPRVC MTVDSLVNKE CCPRLGAESA NVCGSQQGRG QCTEVRADTR PWSGPYILRN QDDRELWPRK FFHRTCKCTG NFAGYNCGDC KFGWTGPNCE RKKPPVIRQN IHSLSPQERE QFLGALDLAK KRVHPDYVIT TQHWLGLLGP NGTQPQFANC SVYDFFVWLH YYSVRDTLLG PGRPYRAIDF SHQGPAFVTW HRYHLLCLER DLQRLIGNES FALPYWNFAT GRNECDVCTD QLFGAARPDD PTLISRNSRF SSWETVCDSL DDYNHLVTLC NGTYEGLLRR NQMGRNSMKL PTLKDIRDCL SLQKFDNPPF FQNSTFSFRN A (1-350 aa encoded by BC028311)

Target Information

The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.

Journal of cellular and molecular medicine

Xie Y,Mei X,Shi W

Sat Apr 01 00:00:00 EDT 2023

Silver Carp (Hypophthalmichthys molitrix) Scale Collagen Peptides-1 (SCPs1) Inhibit Melanogenesis through Downregulation of the cAMP-CREB Signaling Pathway.

Nutrients

Li HL,Li MJ,Xiong GQ,Cai J,Liao T,Zu XY

Wed May 24 00:00:00 EDT 2023

Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells.

Experimental eye research

Gao F,Wang L,Wu B,Ou Q,Tian H,Xu J,Jin C,Zhang J,Wang J,Lu L,Xu GT

Sat Oct 01 00:00:00 EDT 2022

Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion.

Pharmaceutics

Tang X,Dong Q,Li J,Li F,Michniak-Kohn BB,Zhao D,Ho CT,Huang Q

Sat Jul 31 00:00:00 EDT 2021

Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi.

Cell reports

Eshiba S,Namiki T,Mohri Y,Aida T,Serizawa N,Shibata T,Morinaga H,Nanba D,Hiraoka Y,Tanaka K,Miura K,Tanaka M,Uhara H,Yokozeki H,Saida T,Nishimura EK

Tue Aug 03 00:00:00 EDT 2021

A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens.

Asian journal of pharmaceutical sciences

Li M,Qin M,Song G,Deng H,Wang D,Wang X,Dai W,He B,Zhang H,Zhang Q

Fri Jan 01 00:00:00 EST 2021

Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin.

Current biology : CB

Buhr ED,Vemaraju S,Diaz N,Lang RA,Van Gelder RN

Mon Oct 21 00:00:00 EDT 2019

Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.

Scientific reports

Fehrenbach S,Novak D,Bernhardt M,Larribere L,Boukamp P,Umansky V,Utikal J

Fri Jul 08 00:00:00 EDT 2016

Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.

Scientific reports

Fehrenbach S,Novak D,Bernhardt M,Larribere L,Boukamp P,Umansky V,Utikal J

Fri Jul 08 00:00:00 EDT 2016

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2.

Cancer letters

Luo C,Merz PR,Chen Y,Dickes E,Pscherer A,Schadendorf D,Eichmüller SB

Sun Dec 01 00:00:00 EST 2013

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2.

Cancer letters

Luo C,Merz PR,Chen Y,Dickes E,Pscherer A,Schadendorf D,Eichmüller SB

Sun Dec 01 00:00:00 EST 2013

miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes.

The Journal of investigative dermatology

Luo C,Tetteh PW,Merz PR,Dickes E,Abukiwan A,Hotz-Wagenblatt A,Holland-Cunz S,Sinnberg T,Schittek B,Schadendorf D,Diederichs S,Eichmüller SB

Fri Mar 01 00:00:00 EST 2013

miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes.

The Journal of investigative dermatology

Luo C,Tetteh PW,Merz PR,Dickes E,Abukiwan A,Hotz-Wagenblatt A,Holland-Cunz S,Sinnberg T,Schittek B,Schadendorf D,Diederichs S,Eichmüller SB

Fri Mar 01 00:00:00 EST 2013

Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine.

Gene therapy

Igoucheva O,Grazzini M,Pidich A,Kemp DM,Larijani M,Farber M,Lorton J,Rodeck U,Alexeev V

Sun Sep 01 00:00:00 EDT 2013

Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine.

Gene therapy

Igoucheva O,Grazzini M,Pidich A,Kemp DM,Larijani M,Farber M,Lorton J,Rodeck U,Alexeev V

Sun Sep 01 00:00:00 EDT 2013

Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells.

International journal of molecular sciences

Su TR,Lin JJ,Tsai CC,Huang TK,Yang ZY,Wu MO,Zheng YQ,Su CC,Wu YJ

Mon Oct 14 00:00:00 EDT 2013

Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells.

International journal of molecular sciences

Su TR,Lin JJ,Tsai CC,Huang TK,Yang ZY,Wu MO,Zheng YQ,Su CC,Wu YJ

Mon Oct 14 00:00:00 EDT 2013

Transcriptome analysis and molecular signature of human retinal pigment epithelium.

Human molecular genetics

Strunnikova NV,Maminishkis A,Barb JJ,Wang F,Zhi C,Sergeev Y,Chen W,Edwards AO,Stambolian D,Abecasis G,Swaroop A,Munson PJ,Miller SS

Tue Jun 15 00:00:00 EDT 2010

Transcriptome analysis and molecular signature of human retinal pigment epithelium.

Human molecular genetics

Strunnikova NV,Maminishkis A,Barb JJ,Wang F,Zhi C,Sergeev Y,Chen W,Edwards AO,Stambolian D,Abecasis G,Swaroop A,Munson PJ,Miller SS

Tue Jun 15 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: DCT; DOPAchrome conversion factor; dopachrome delta-isomerase; DOPAchrome isomerase; DOPAchrome oxidoreductase; dopachrome tautomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; L-dopachrome Delta-isomerase; L-dopachrome isomerase; L-dopachrome tautomerase; SLATY locus protein; TRP-2; TRP2; tyrosinase related protein-2; Tyrosinase-related protein 2; tyrosinase-related protein-2; tyrosine-related protein 2

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Gene Aliases: DCT; DT; RGD1564975; slaty; slt; TRP-2; TRP2; Tyrp-2; TYRP2

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UniProt ID: (Human) P40126, (Mouse) P29812

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Entrez Gene ID: (Human) 1638, (Rat) 290484, (Mouse) 13190

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Function(s)

dopachrome isomerase activity copper ion binding oxidoreductase activity isomerase activity metal ion binding oxygenase

Process(es)

positive regulation of neuroblast proliferation melanin biosynthetic process from tyrosine epidermis development ventricular zone neuroblast division developmental pigmentation cell development oxidation-reduction process melanin biosynthetic process pigmentation metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DCT Polyclonal Antibody

DCT Antibody (13095-1-AP) in IHC (P)

Product Details

13095-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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