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DCX Polyclonal Antibody

DCX Antibody in Immunocytochemistry (ICC/IF)

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DCX Antibody (13925-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed SH-SY5Y cells using (Product # 13925-1-AP) (DCX antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

DCX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

13925-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 13 publications 13 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DCX Fusion Protein Ag4945 (1-360 aa encoded by BC027925)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Anti-DCX antibodies are widely used for detection of neurogenesis. It is also a common neuron marker since its expression is specific to neurons.

Immunogen sequence: MELDFGHFD ERDKTSRNMR GSRMNGLPSP THSAHCSFYR TRTLQALSNE KKAKKVRFYR NGDRYFKGIV YAVSSDRFRS FDALLADLTR SLSDNINLPQ GVRYIYTIDG SRKIGSMDEL EEGESYVCSS DNFFKKVEYT KNVNPNWSVN VKTSANMKAP QSLASSNSAQ ARENKDFVRP KLVTIIRSGV KPRKAVRVLL NKKTAHSFEQ VLTDITEAIK LETGVVKKLY TLDGKQVTCL HDFFGDDDVF IACGPEKFRY AQDDFSLDEN ECRVMKGNPS ATAGPKASPT PQKTSAKSPG PMRRSKSPAD SANGTSSSQL STPKSKQSPI STPTSPGSLR KHKDLYLPLS LDDSDSLGDS M (1-360 aa encoded by BC027925)

Target Information

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.

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Tue Oct 11 00:00:00 EDT 2022

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Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain.

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Bioinformatics

Protein Aliases: doublecortex; Doublin; Lis-X; LIS-XD; Lissencephalin-X; lissencephaly, X-linked (doublecortin); Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316

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Gene Aliases: DBCN; Dbct; DC; Dcn; DCX; LISX; SCLH; XLIS

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UniProt ID: (Human) O43602, (Mouse) O88809

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Entrez Gene ID: (Human) 1641, (Mouse) 13193

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Function(s)

calmodulin-dependent protein kinase activity protein binding calmodulin binding microtubule binding calcium-dependent protein serine/threonine kinase activity protein kinase binding

Process(es)

neuron migration multicellular organism development nervous system development brain development peptidyl-serine phosphorylation central nervous system projection neuron axonogenesis cell differentiation intracellular signal transduction protein autophosphorylation axon extension dendrite morphogenesis central nervous system development hippocampus development layer formation in cerebral cortex pyramidal neuron development response to electrical stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DCX Polyclonal Antibody

DCX Antibody (13925-1-AP) in ICC/IF

Product Details

13925-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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