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Antibody detects endogenous levels of total DDA1.
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). [UniProt]
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Protein Aliases: cross-immune reaction antigen PCIA1; DET1- and DDB1-associated protein 1; PCIA-1; Placenta cross-immune reaction antigen 1
Gene Aliases: 1500034J01Rik; 1700095J19Rik; C19orf58; DDA1; PCIA1; R74921
UniProt ID: (Human) Q9BW61, (Mouse) Q9D9Z5
Entrez Gene ID: (Human) 79016, (Mouse) 66498, (Rat) 688813
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