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DEDD Antibody (TA811967) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DEDD (RC212926, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DEDD. (1. Positive lysates LY409798 (100 µg) and LC409798 (20 µg) can be purchased separately from OriGene.
Product Details
TA811967
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI7C9
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-318 of human DEDD produced in E.coli.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DEDD encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Death effector domain-containing protein; Death effector domain-containing testicular molecule; DEDPro1; FLDED-1
Gene Aliases: CASP8IP1; DEDD; DEDD1; DEDPRO1; DEFT; FLDED1; KE05
UniProt ID: (Human) O75618
Entrez Gene ID: (Human) 9191
transcription, DNA-templated
spermatogenesis
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein catabolic process
regulation of apoptotic process
decidualization
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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