Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MKFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTCCH WGETALFMCN ASRKCCISYS FLPKPDLPQL IGNHWQSRRR NTQRKDKKQQ TTVTS; Positive Samples: Mouse testis, Mouse liver
Beta-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, beta-defensins are developmentally regulated. The family of beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many beta-defensins also are involved in sperm maturation and capacitation. beta-defensin 32, also known as beta-defensin 132, is a 95 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active.
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