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Product Details
PA5-72129
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2717983
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carcinoma related; Degradation in endoplasmic reticulum protein 2; Der1-like protein 2; derlin 2; Derlin-2; F-LANa
Gene Aliases: CGI-101; Der2; Derl2; Derlin-2; F-lana; Flana
UniProt ID: (Mouse) Q8BNI4
Entrez Gene ID: (Mouse) 116891
suckling behavior
response to unfolded protein
positive regulation of cell proliferation
positive regulation of cell growth
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
negative regulation of retrograde protein transport, ER to cytosol
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