Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PKSGGLKGR DLLCSFRKLL NPHQVFDLTN GGPLPGLHLF SQVPCFRVLV CGGDGTVGWV LGALEETRYR LACPEPSVAI LPLGTGNDLG RVLRWGAGYS GEDPFSVLLS VDEADAVLMD RWTILLDAHE AGSAENDTAD AEPPKIVQMS NYCGIGIDAE LSLDFHQARE EEPGKFTSRL HNKGVYVRVG LQKISHSRSL HKQIRLQVER QEVELPSIEG LIFINIPSWG SGADLWGSDS DTRFEKPRMD DGLLEVVGVT GVVHMGQVQG GLRSGIRIAQ GSYFRVTLLK ATPVQVDGEP WVQAPGHMII SAAGPKVHML RKAKQKPRRA GTTRDARADA APAPESDPR (595-942 aa encoded by BC063801)
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAG kinase theta; Dgk theta; DGK-theta; Diacylglycerol kinase theta; diacylglycerol kinase, delta (110 kDa); diacylglycerol kinase, theta 110kDa; Diglyceride kinase theta; testis tissue sperm-binding protein Li 38a
Gene Aliases: 110kDa; DAGK; DAGK4; DAGK7; Dgkd; DGKQ
UniProt ID: (Human) P52824, (Rat) D3ZEY4, (Mouse) Q6P5E8
Entrez Gene ID: (Human) 1609, (Rat) 100361138, (Mouse) 110524
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