Proteintech

DKK1 Polyclonal Antibody

DKK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DKK1 Antibody (21112-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta tissue slide using 21112-1-AP (DKK1 Antibody) at dilution of 1:200 (under 40x lens).

Product Image Gallery

Product Details

21112-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DKK1 Fusion Protein Ag15110 (32-191 aa encoded by BC001539)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TLNSVLNSN AIKNLPPPLG GAAGHPGSAV SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH TKGQEGSVCL R (32-191 aa encoded by BC001539)

Target Information

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lan XB,Ni YS,Liu N,Wei W,Liu Y,Yang JM,Ma L,Bai R,Zhang J,Yu JQ

Wed Mar 01 00:00:00 EST 2023

Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.

Environmental toxicology

Wang T,Huang X,Liu J,Liu W,Yang Z,He K,Chen J,Zhao L

Mon May 01 00:00:00 EDT 2023

Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.

Environmental toxicology

Wang T,Huang X,Liu J,Liu W,Yang Z,He K,Chen J,Zhao L

Mon May 01 00:00:00 EDT 2023

RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression.

Cell death & disease

Dong Z,Li J,Dai W,Yu D,Zhao Y,Liu S,Li X,Zhang Z,Zhang R,Liang X,Kong Q,Jin S,Jiang H,Jiang W,Ding C

Tue Feb 07 00:00:00 EST 2023

Retracted Article: Exosomes from bone marrow mesenchymal stem cells promoted osteogenic differentiation by delivering miR-196a that targeted Dickkopf-1 to activate Wnt/β-catenin pathway.

Bioengineered

Peng Z,Lu S,Lou Z,Li Z,Li S,Yang K,Li C

Fri Dec 01 00:00:00 EST 2023

Dickkopf-1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11/SREBP2/ABCA1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li X,Zheng T,Zhang Y,Zhao Y,Liu F,Dai S,Liu X,Zhang M

Tue Aug 01 00:00:00 EDT 2023

Expression of Dickkopf-1 and Twist2 in Cervical Squamous Cell Carcinoma and Their Correlation with Vasculogenic Mimicry.

Journal of healthcare engineering

Wang B,Zhang H,Wei L,Li Y

Fri May 06 00:00:00 EDT 2022

Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis.

Nature communications

Wu M,Zhang X,Zhang W,Chiou YS,Qian W,Liu X,Zhang M,Yan H,Li S,Li T,Han X,Qian P,Liu S,Pan Y,Lobie PE,Zhu T

Wed Mar 16 00:00:00 EDT 2022

A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.

Frontiers in oncology

Cui Y,Wang X,Zhang L,Liu W,Ning J,Gu R,Cui Y,Cai L,Xing Y

Tue Oct 04 00:00:00 EDT 2022

miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.

Biochemical pharmacology

Han S,Wang Z,Liu J,Wang HD,Yuan Q

Tue Jun 01 00:00:00 EDT 2021

Transcriptome sequencing profiling identifies miRNA-331-3p as an osteoblast-specific miRNA in infected bone nonunion.

Bone

Zhang Y,Wang X,Huang X,Shen L,Zhang L,Shou D,Fan X

Mon Feb 01 00:00:00 EST 2021

ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expression.

Cell death & disease

Ding G,Lu W,Zhang Q,Li K,Zhou H,Wang F,Zhao C,Fan C,Wang J

Mon Oct 25 00:00:00 EDT 2021

Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Melanoma.

International journal of general medicine

Zhou YX,Wang X,Pang DQ,Wang YM,Bai J,Tian F,Han D,Shi S,Hu L

Sun Apr 24 00:00:00 EDT 2022

Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.

Phytotherapy research : PTR

Liu H,Guo Y,Zhu R,Wang L,Chen B,Tian Y,Li R,Ma R,Jia Q,Zhang H,Xia B,Li Y,Wang X,Zhu X,Zhang R,Br¿mme D,Gao S,Zhang D,Pei X

Fri Jan 01 00:00:00 EST 2021

Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.

Phytotherapy research : PTR

Liu H,Guo Y,Zhu R,Wang L,Chen B,Tian Y,Li R,Ma R,Jia Q,Zhang H,Xia B,Li Y,Wang X,Zhu X,Zhang R,Br¿mme D,Gao S,Zhang D,Pei X

Fri Jan 01 00:00:00 EST 2021

A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.

Gene

Ni D,Yi Q,Liu J,Hu Y,Lv T,Tan G,Liu Y,Xu L,Xia H,Zhou Q,Xie Y

Tue Mar 10 00:00:00 EDT 2020

Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.

Cancer management and research

Ping MH

Mon Apr 18 00:00:00 EDT 2022

BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.

Cancer science

Yu YP,Cai LC,Wang XY,Cheng SY,Zhang DM,Jian WG,Wang TD,Yang JK,Yang KB,Zhang C

Fri May 01 00:00:00 EDT 2020

Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Liu C,Wang L,Zhu R,Liu H,Ma R,Chen B,Li L,Guo Y,Jia Q,Shi S,Zhao D,Mo F,Zhao B,Niu J,Fu M,Orekhov AN,Brömme D,Gao S,Zhang D

Fri Feb 01 00:00:00 EST 2019

Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Liu C,Wang L,Zhu R,Liu H,Ma R,Chen B,Li L,Guo Y,Jia Q,Shi S,Zhao D,Mo F,Zhao B,Niu J,Fu M,Orekhov AN,Brömme D,Gao S,Zhang D

Fri Feb 01 00:00:00 EST 2019

Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

Journal of molecular histology

Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

Fri Feb 01 00:00:00 EST 2019

Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

Journal of molecular histology

Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

Fri Feb 01 00:00:00 EST 2019

Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.

Journal of experimental & clinical cancer research : CR

Wu Z,Liu Z,Jiang X,Mi Z,Meng M,Wang H,Zhao J,Zheng B,Yuan Z

Tue Aug 06 00:00:00 EDT 2019

A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway.

In vitro cellular & developmental biology. Animal

Ni D,Liu J,Hu Y,Liu Y,Gu Y,Zhou Q,Xie Y

Mon Apr 01 00:00:00 EDT 2019

LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.

Cancer cell international

Ye Z,Duan J,Wang L,Ji Y,Qiao B

Mon Apr 11 00:00:00 EDT 2022

Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.

BioFactors (Oxford, England)

Zhang H,Shi Q,Nan W,Wang Y,Wang S,Yang F,Li G

Fri Nov 01 00:00:00 EDT 2019

UPLC-Q-TOF/MS characterization of efficacy substances on osteoblasts differentiation and function in rat serum after administration of Wang-Bi tablet.

Biomedical chromatography : BMC

Wang H,Guan Y,Wu R,Lv X,Shen X,Ye G

Tue Oct 01 00:00:00 EDT 2019

Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.

Phytotherapy research : PTR

Liu H,Zhu R,Wang L,Liu C,Ma R,Qi B,Chen B,Li L,Guo Y,Shi S,Jia Q,Niu J,Zhao D,Mo F,Gao S,Zhang D

Sat Dec 01 00:00:00 EST 2018

Phytotherapy research : PTR

Liu H,Zhu R,Wang L,Liu C,Ma R,Qi B,Chen B,Li L,Guo Y,Shi S,Jia Q,Niu J,Zhao D,Mo F,Gao S,Zhang D

Sat Dec 01 00:00:00 EST 2018

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 EDT 2022

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 EDT 2022

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.

Theranostics

Zhang P,Li S,Lv C,Si J,Xiong Y,Ding L,Ma Y,Yang Y

Thu Sep 05 00:00:00 EDT 2019

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.

Theranostics

Zhang P,Li S,Lv C,Si J,Xiong Y,Ding L,Ma Y,Yang Y

Thu Sep 05 00:00:00 EDT 2019

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.

Theranostics

Zhang P,Li S,Lv C,Si J,Xiong Y,Ding L,Ma Y,Yang Y

Thu Sep 05 00:00:00 EDT 2019

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.

Theranostics

Zhang P,Li S,Lv C,Si J,Xiong Y,Ding L,Ma Y,Yang Y

Thu Sep 05 00:00:00 EDT 2019

Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Yan X,Li Q,Ni D,Xie Y,He Q,Wan Q,Liu Y,Lyu Z,Mao Z,Zhou Q

Thu Jun 01 00:00:00 EDT 2017

Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Yan X,Li Q,Ni D,Xie Y,He Q,Wan Q,Liu Y,Lyu Z,Mao Z,Zhou Q

Thu Jun 01 00:00:00 EDT 2017

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC).

Oncotarget

Liu BL,Sun KX,Zong ZH,Chen S,Zhao Y

Tue Feb 09 00:00:00 EST 2016

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC).

Oncotarget

Liu BL,Sun KX,Zong ZH,Chen S,Zhao Y

Tue Feb 09 00:00:00 EST 2016

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 EST 2016

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 EST 2016

Bioinformatics

Protein Aliases: dickkopf 1 homolog; dickkopf homolog 1; dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; dkk-1; hDkk-1; hDkk1; SK

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Gene Aliases: DKK-1; DKK1; mdkk-1; SK; UNQ492/PRO1008

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UniProt ID: (Human) O94907, (Mouse) O54908

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Entrez Gene ID: (Human) 22943, (Mouse) 13380, (Rat) 293897

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Function(s)

signal transducer activity protein binding growth factor activity co-receptor binding receptor antagonist activity low-density lipoprotein particle receptor binding molecular_function

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DKK1 Polyclonal Antibody

DKK1 Antibody (21112-1-AP) in IHC (P)

Product Details

21112-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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