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Product Details
PA5-27367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 264 and 469 of Human DLD
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2544843
Product Specific Information
Recommended positive controls: 293T, mouse brain, PC-12, Rat2.
Predicted reactivity: Mouse (96%), Rat (96%), Xenopus laevis (94%), Dog (98%), Pig (99%), Chicken (93%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: branched chain alpha-keto acid dehydrogenase complex subunit E3; diaphorase; Dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); Dihydrolipoyl dehydrogenase, mitochondrial; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; Glycine cleavage system L protein; glycine cleavage system protein L; lipoamide dehydrogenase; lipoamide reductase; lipoyl dehydrogenase; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PHE 3
Gene Aliases: DLD; DLDD; DLDH; E3; GCSL; LAD; PHE3
UniProt ID: (Human) P09622, (Rat) Q6P6R2, (Mouse) O08749
Entrez Gene ID: (Human) 1738, (Rat) 298942, (Mouse) 13382
dihydrolipoyl dehydrogenase activity
pyruvate dehydrogenase (NAD+) activity
lipoamide binding
flavin adenine dinucleotide binding
NAD binding
mercury (II) reductase activity
mercury ion binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
oxidoreductase
pyruvate metabolic process
tricarboxylic acid cycle
2-oxoglutarate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
lysine catabolic process
gastrulation
aging
branched-chain amino acid catabolic process
lipoate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of membrane potential
cell redox homeostasis
glyoxylate metabolic process
sperm capacitation
dihydrolipoamide metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
acetyl-CoA biosynthetic process from pyruvate
detoxification of mercury ion
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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