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OriGene
DLD Monoclonal Antibody (OTI8A10), TrueMAB™
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Product Details
CF503388
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI8A10
Immunogen
Full length human recombinant protein of human DLD produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: branched chain alpha-keto acid dehydrogenase complex subunit E3; diaphorase; Dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoamide: NAD+ oxidoreductase; Dihydrolipoyl dehydrogenase, mitochondrial; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; Glycine cleavage system L protein; glycine cleavage system protein L; lipoamide dehydrogenase; lipoamide reductase; lipoyl dehydrogenase; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PHE 3
Gene Aliases: DLD; DLDD; DLDH; E3; GCSL; LAD; PHE3
UniProt ID: (Dog) P49819, (Human) P09622, (Rat) Q6P6R2, (Mouse) O08749
Entrez Gene ID: (Dog) 403978, (Human) 1738, (Rat) 298942, (Mouse) 13382
dihydrolipoyl dehydrogenase activity
flavin adenine dinucleotide binding
pyruvate dehydrogenase (NAD+) activity
lipoamide binding
NAD binding
mercury (II) reductase activity
mercury ion binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
oxidoreductase
cell redox homeostasis
oxidation-reduction process
histone succinylation
pyruvate metabolic process
tricarboxylic acid cycle
2-oxoglutarate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
lysine catabolic process
gastrulation
aging
branched-chain amino acid catabolic process
lipoate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of membrane potential
glyoxylate metabolic process
sperm capacitation
dihydrolipoamide metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
acetyl-CoA biosynthetic process from pyruvate
detoxification of mercury ion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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