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Product Details
81609-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1I13
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE EYSCFSFRKL WAFTGPGFLM
Target Information
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dct-1; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; microcytic anemia, viable anaemia; Natural resistance-associated macrophage protein 2; NRAMP 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
Gene Aliases: AHMIO1; DCT1; DMT1; mk; NRAMP2; OK/SW-cl.20; SLC11A2; van
UniProt ID: (Human) P49281, (Mouse) P49282, (Rat) O54902
Entrez Gene ID: (Human) 4891, (Mouse) 18174, (Rat) 25715
copper ion transmembrane transporter activity
iron ion transmembrane transporter activity
manganese ion transmembrane transporter activity
protein binding
hydrogen ion transmembrane transporter activity
cadmium ion transmembrane transporter activity
cobalt ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
lead ion transmembrane transporter activity
solute:proton symporter activity
ferrous iron uptake transmembrane transporter activity
transferrin transmembrane transporter activity
cadmium ion binding
transition metal ion transmembrane transporter activity
transporter activity
iron ion binding
copper ion binding
zinc ion binding
nickel cation transmembrane transporter activity
vanadium ion transmembrane transporter activity
nickel cation binding
inorganic cation transmembrane transporter activity
manganese ion binding
cobalt ion binding
zinc ion transmembrane transporter activity
calcium ion transmembrane transporter activity
chromium ion transmembrane transporter activity
secondary carrier transporter
heme biosynthetic process
cobalt ion transport
copper ion transport
manganese ion transport
cellular iron ion homeostasis
learning or memory
response to iron ion
ferrous iron transport
lead ion transport
transferrin transport
copper ion transmembrane transport
dendrite morphogenesis
erythrocyte development
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
ferrous iron import
manganese ion transmembrane transport
hydrogen ion transmembrane transport
ferrous iron transmembrane transport
transition metal ion transport
porphyrin-containing compound metabolic process
porphyrin-containing compound biosynthetic process
transport
ion transport
iron ion transport
cellular copper ion homeostasis
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to manganese ion
nickel cation transport
vanadium ion transport
proton transport
cellular response to oxidative stress
iron ion transmembrane transport
nickel cation transmembrane transport
iron ion homeostasis
zinc II ion transmembrane transport
cation transmembrane transport
copper ion import into cell
response to hypoxia
detection of oxygen
response to lead ion
response to cadmium ion
cellular response to iron ion
cellular response to tumor necrosis factor
cellular response to hypoxia
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