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Product Details
PA5-82848
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DMTF1. Recombinant protein control fragment (Product #RP-89350).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790004
Product Specific Information
Immunogen sequence: ASPTVTLTAA APASPEQIIV HALSPEHLLN TSDNVTVQCH TPRVIIQTVA TEDITSSISQ AELTVDSDIQ SSDFPEPPDA LEADTFPDEI HHPKMTVEPS FNDAHVSKFS DQNSTELMNS VMVRTEEEI
Target Information
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin D binding myb-like transcription factor 1; cyclin D-binding Myb-like protein; Cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; FLJ41265; hDMP1; hDMTF1
Gene Aliases: DMP1; DMTF; DMTF1; hDMP1; MRUL
UniProt ID: (Human) Q9Y222
Entrez Gene ID: (Human) 9988
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor recruiting
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
DNA-binding transcription factor
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