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Product Details
PA5-38026
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
18 amino acid peptide near the carboxy terminus of human DNAJC13
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554630
Product Specific Information
A recommended positive control is human heart tissue lysate.
At least two isoforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is not expected to cross-react with other DNAJC family members.
Target Information
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; j-domain containing protein, required for endocytosis; receptor mediated endocytosis RME-8; Required for receptor-mediated endocytosis 8; RME-8
Gene Aliases: D030002L11Rik; DNAJC13; Gm1124; KIAA0678; mKIAA0678; PARK21; RME-8; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317, (Mouse) 235567
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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