Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
91175ACTMOTIF
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
This antibody was raised against recombinant protein comprising full length human DNMT1 (DNA (cytosine-5)-methyltransferase 1).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
140mM HEPES/32mM sodium acetate, pH 7.5, with 30% glycerol, 70mM NaCl
Contains
0.035% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; Dnmt1; FLJ16293; MCMT; MGC104992
Gene Aliases: ADCADN; AIM; CXXC9; DNMT; DNMT1; HSN1E; m.HsaI; MCMT
UniProt ID: (Human) P26358
Entrez Gene ID: (Human) 1786
DNA binding
double-stranded DNA binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
promoter-specific chromatin binding
DNA metabolism protein
DNA methyltransferase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
Ras protein signal transduction
brain development
aging
response to heat
response to toxic substance
response to ionizing radiation
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
gene silencing
covalent chromatin modification
neuron differentiation
response to caffeine
response to estradiol
response to lipopolysaccharide
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
regulation of cell proliferation
DNA hypermethylation
response to ethanol
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
positive regulation of methylation-dependent chromatin silencing
cellular response to nerve growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support