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Product Details
PA1-9542
Product Specifications
Species Reactivity
Human
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Purified recombinant DNMT3L.1 corresponding to the chromosome 21 gene (Human).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
IgY fraction
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2261822
Product Specific Information
PA1-9542 detects DNMT3L in human samples.
PA1-9542 has been successfully used in Western blot procedures. By Western blot, PA1-9542 detects a 47 kDa protein representing DNMT3L.
PA1-9542 immunogen is a purified recombinant DNMT3L.1 corresponding to the chromosome 21 gene (Human).
Target Information
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; Dnmt3; Dnmt3b; m.MmuIIIB; MGC1090
Gene Aliases: DNMT3B; ICF; ICF1; M.HsaIIIB
UniProt ID: (Human) Q9UBC3
Entrez Gene ID: (Human) 1789
chromatin binding
transcription corepressor activity
DNA (cytosine-5-)-methyltransferase activity
protein binding
DNA-methyltransferase activity
histone deacetylase binding
unmethylated CpG binding
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
DNA methyltransferase
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
DNA methylation
response to toxic substance
response to ionizing radiation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
response to caffeine
response to estradiol
response to vitamin A
response to cocaine
response to drug
positive regulation of neuron differentiation
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to hyperoxia
cellular response to dexamethasone stimulus
C-5 methylation of cytosine
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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