Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: VELSVLFCKFI QSIPDNQLVR QKLNCMTKIV ESTLFRQSEC REVLLPLLTD QLSGQLDDNS NKPDHEASSQ LL
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dedicator of cytokinesis protein 5; FLJ21034
Gene Aliases: DOCK5
UniProt ID: (Human) Q9H7D0
Entrez Gene ID: (Human) 80005
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