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Search Thermo Fisher Scientific
Immunogen sequence: EVYKLVIPI LEAHREFRKL TLTHSKLQRA FDSIVNKDHK RMFGTYFRVG FFGSKFGDLD EQEFVYKEPA ITKLPEISHR LEAFYGQCFG AEFVEVIKDS TPVDKTKLDP NKAYIQITFV EPYFDEYEMK DRVTYFEKNF NLRRFMYTTP FTLEGRPRGE LHEQYRRNTV LTTMHAFPYI KTRISVIQKE EFVLTPIEVA IEDMKKKTLQ LAVAINQEPP DAKMLQMVLQ GSVGATVNQG PLEVAQVFLA EIPADPKLYR HHNKLRLCFK EFIMRCGEAV EKNKRLITAD QREYQQELKK NYNKLKENLR PMIERKIPEL YKPIFRVESQ KRDSFHRSSF RKCETQLSQG S (257-606 aa encoded by BC019102)
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1200017A24Rik; Dedicator of cytokinesis protein 8; epididymis luminal protein 205
Gene Aliases: 1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977; DOCK8; HEL-205; MRD2; ZIR8
UniProt ID: (Human) Q8NF50, (Mouse) Q8C147
Entrez Gene ID: (Human) 81704, (Mouse) 76088
Molecular Function:
guanyl-nucleotide exchange factor
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