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DOPA decarboxylase Polyclonal Antibody

DOPA decarboxylase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DOPA decarboxylase Antibody (10166-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 10166-1-AP (DOPA decarboxylase antibody) at dilution of 1:5000 (under 10x lens). Data from NeuroScience Associates, Inc.

DOPA decarboxylase Antibody in Western Blot (WB)

DOPA decarboxylase Antibody in Immunoprecipitation (IP)

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Product Details

10166-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:600

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DOPA decarboxylase Fusion Protein Ag0219 (121-389 aa encoded by BC008366)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: WLGKMLELP KAFLNEKAGE GGGVIQGSAS EATLVALLAA RTKVIHRLQA ASPELTQAAI MEKLVAYSSD QAHSSVERAG LIGGVKLKAI PSDGNFAMRA SALQEALERD KAAGLIPFFM VATLGTTTCC SFDNLLEVGP ICNKEDIWLH VDAAYAGSAF ICPEFRHLLN GVEFADSFNF NPHKWLLVNF DCSAMWVKKR TDLTGAFRLD PTYLKHSHQD SGLITDYRHW QIPLGRRFRS LKMWFVFRMY GVKGLQAYIR KHVQLSHEFE (121-389 aa encoded by BC008366)

Target Information

DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.

Molecular immunology

Jin J,Xu F,Zhang Y,Guan J,Fu J

Wed Mar 01 00:00:00 EST 2023

Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.

Molecular immunology

Jin J,Xu F,Zhang Y,Guan J,Fu J

Wed Mar 01 00:00:00 EST 2023

Profile of 5-HT_2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride-induced hepatotoxicity.

Cellular signalling

Zhang Y,Wang Y,Zhang K,Liang X,Guan J,Jin J,Zhang Y,Xu F,Yang L,Fu J

Mon May 01 00:00:00 EDT 2023

Profile of 5-HT_2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride-induced hepatotoxicity.

Cellular signalling

Zhang Y,Wang Y,Zhang K,Liang X,Guan J,Jin J,Zhang Y,Xu F,Yang L,Fu J

Mon May 01 00:00:00 EDT 2023

Profile of 5-HT_2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride-induced hepatotoxicity.

Cellular signalling

Zhang Y,Wang Y,Zhang K,Liang X,Guan J,Jin J,Zhang Y,Xu F,Yang L,Fu J

Mon May 01 00:00:00 EDT 2023

Profile of 5-HT_2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride-induced hepatotoxicity.

Cellular signalling

Zhang Y,Wang Y,Zhang K,Liang X,Guan J,Jin J,Zhang Y,Xu F,Yang L,Fu J

Mon May 01 00:00:00 EDT 2023

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease.

Disease models & mechanisms

Li ZF,Cui L,Jin MM,Hu DY,Hou XG,Liu SS,Zhang X,Zhu JH

Tue Mar 01 00:00:00 EST 2022

Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H⁺] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.

Toxicology and applied pharmacology

Zhang Y,Liang X,Guan J,Jin J,Zhang Y,Xu F,Fu J

Tue Mar 15 00:00:00 EDT 2022

Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H⁺] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.

Toxicology and applied pharmacology

Zhang Y,Liang X,Guan J,Jin J,Zhang Y,Xu F,Fu J

Tue Mar 15 00:00:00 EDT 2022

Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H⁺] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.

Toxicology and applied pharmacology

Zhang Y,Liang X,Guan J,Jin J,Zhang Y,Xu F,Fu J

Tue Mar 15 00:00:00 EDT 2022

Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H⁺] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.

Toxicology and applied pharmacology

Zhang Y,Liang X,Guan J,Jin J,Zhang Y,Xu F,Fu J

Tue Mar 15 00:00:00 EDT 2022

A genetic map of the mouse dorsal vagal complex and its role in obesity.

Nature metabolism

Ludwig MQ,Cheng W,Gordian D,Lee J,Paulsen SJ,Hansen SN,Egerod KL,Barkholt P,Rhodes CJ,Secher A,Knudsen LB,Pyke C,Myers MG,Pers TH

Thu Apr 01 00:00:00 EDT 2021

Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Nature

Qian H,Kang X,Hu J,Zhang D,Liang Z,Meng F,Zhang X,Xue Y,Maimon R,Dowdy SF,Devaraj NK,Zhou Z,Mobley WC,Cleveland DW,Fu XD

Mon Jun 01 00:00:00 EDT 2020

Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis.

Journal of chemical neuroanatomy

Carter DA

Sat Jul 01 00:00:00 EDT 2017

Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis.

Journal of chemical neuroanatomy

Carter DA

Sat Jul 01 00:00:00 EDT 2017

Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice.

Toxicology and applied pharmacology

Fox DA,Hamilton WR,Johnson JE,Xiao W,Chaney S,Mukherjee S,Miller DB,O'Callaghan JP

Tue Nov 01 00:00:00 EDT 2011

Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice.

Toxicology and applied pharmacology

Fox DA,Hamilton WR,Johnson JE,Xiao W,Chaney S,Mukherjee S,Miller DB,O'Callaghan JP

Tue Nov 01 00:00:00 EDT 2011

Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice.

Toxicology and applied pharmacology

Fox DA,Hamilton WR,Johnson JE,Xiao W,Chaney S,Mukherjee S,Miller DB,O'Callaghan JP

Tue Nov 01 00:00:00 EDT 2011

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.

Journal of translational medicine

Ming M,Li X,Fan X,Yang D,Li L,Chen S,Gu Q,Le W

Sun Jun 28 00:00:00 EDT 2009

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.

Journal of translational medicine

Ming M,Li X,Fan X,Yang D,Li L,Chen S,Gu Q,Le W

Sun Jun 28 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: AADC; aromatic L-amino acid decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; L-Dopa decarboxylase

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Gene Aliases: AADC; DDC

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UniProt ID: (Human) P20711, (Mouse) O88533, (Rat) P14173

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Entrez Gene ID: (Human) 1644, (Mouse) 13195, (Rat) 24311

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Function(s)

aromatic-L-amino-acid decarboxylase activity protein binding amino acid binding enzyme binding protein domain specific binding pyridoxal phosphate binding L-dopa decarboxylase activity catalytic activity lyase activity carboxy-lyase activity decarboxylase

Process(es)

cellular amino acid metabolic process circadian rhythm multicellular organism aging aminergic neurotransmitter loading into synaptic vesicle isoquinoline alkaloid metabolic process cellular response to drug dopamine biosynthetic process catecholamine biosynthetic process serotonin biosynthetic process indolalkylamine biosynthetic process response to pyrethroid phytoalexin metabolic process cellular response to alkaloid cellular response to growth factor stimulus response to toxic substance carboxylic acid metabolic process dopamine metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DOPA decarboxylase Polyclonal Antibody

DOPA decarboxylase Antibody (10166-1-AP) in IHC (P)

Product Details

10166-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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