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Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon (100%); Gorilla, Monkey (94%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
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Protein Aliases: carboxytripeptidase; Dipeptidyl aminopeptidase II; dipeptidyl arylamidase II; Dipeptidyl peptidase 2; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; dipeptidyl-peptidase II; DPP II; Quiescent cell proline dipeptidase
Gene Aliases: DPP2; DPP7; DPPII; QPP
UniProt ID: (Human) Q9UHL4
Entrez Gene ID: (Human) 29952
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