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DPP4 Antibody (MA5-52417) in Flow
Flow cytometry analysis of Mouse DPP4(CD26) expression on BABL/c splenocytes. Samples were incubated with DPP4 monoclonal antibody (Product # MA5-52417). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-52417
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
007
Immunogen
Recombinant Mouse DPP4/CD26 Protein (Ser29-His760)
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; DPP IV; DPP-IV; T-cell activation antigen CD26; THAM; Thymocyte-activating molecule
Gene Aliases: Cd26; Dpp-4; Dpp4; THAM
UniProt ID: (Mouse) P28843
Entrez Gene ID: (Mouse) 13482
virus receptor activity
protease binding
aminopeptidase activity
serine-type endopeptidase activity
receptor binding
collagen binding
peptidase activity
serine-type peptidase activity
dipeptidyl-peptidase activity
hydrolase activity
peptide binding
identical protein binding
protein homodimerization activity
serine protease
behavioral fear response
response to hypoxia
regulation of T cell mediated immunity
proteolysis
cell adhesion
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
T cell costimulation
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
establishment of localization
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